نتائج البحث

Silencing Apoe with divalent‐siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease

• Authors : Ferguson, Chantal M.; Hildebrand, Samuel; Godinho, Bruno M. D. C. ...

Subjects: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology

• Source: Alzheimer's & Dementia ; volume 20, issue 4, page 2632-2652 ; ISSN 1552-5260 1552-5279

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Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection

• Authors : Hariharan, Vignesh N; Shin, Minwook; Chang, Ching-Wen ...

Subjects: SARS-COV-2; antisense oligos; lung

• Source: Proceedings of the National Academy of Sciences of the United States of America ; 120 ; 11 ; e2219523120 ; United States

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Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington's disease models

• Authors : Conroy, Faith; Miller, Rachael; Alterman, Julia F. ...

• Source: Nature communications ; 13 ; 1 ; 5802 ; United States ; England

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Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition

• Authors : Haraszti, Reka A; Miller, Rachael; Dubuke, Michelle L. ...

Subjects: Biochemistry; Biological Sciences; Lipidomics

• Source: iScience ; 16 ; 230-241

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5-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo

• Authors : Haraszti, Reka A; Roux, Loic; Coles, Andrew H. ...

Subjects: Biochemistry; Enzymes and Coenzymes; Nucleic Acids

• Source: Nucleic acids research ; 45 ; 13 ; 7581-7592

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Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep

• Authors : Ferguson, Chantal M.; Godinho, Bruno M D C; Alterman, Julia F. ...

Subjects: Gene therapy; Neurodegeneration; Neuroscience

• Source: JCI insight ; 6 ; 24 ; e152203

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Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways

• Authors : Osborn, Maire F.; Coles, Andrew H.; Biscans, Annabelle ...

Subjects: small interfering RNAs; siRNAs; lipid transport

• Source: Nucleic acids research ; 47 ; 3 ; 1070-1081

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Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain

• Authors : Nikan, Mehran; Osborn, Maire F.; Coles, Andrew H. ...

Subjects: drug delivery; neurodegenerative disease; siRNA

• Source: Molecular therapy. Nucleic acids ; 5 ; 8 ; e344

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Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing

• Authors : Didiot, Marie C.; Hall, Lauren M.; Coles, Andrew H. ...

Subjects: siRNA; Huntingtin; mRNA

• Source: Molecular therapy : the journal of the American Society of Gene Therapy ; 24 ; 10 ; 1836-1847

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Imaging Net Retrograde Axonal Transport In Vivo: A Physiological Biomarker

• Authors : Lee, Pin-Tsun Justin; Kennedy, Zachary C.; Wang, Yuzhen ...

Subjects: motor neurons; axonal transport; UMCCTS funding

• Source: Annals of neurology ; 91 ; 5 ; 716-729

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