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Academic Journal

Modulation of the microhomology-mediated end joining pathway suppresses large deletions and enhances homology-directed repair following CRISPR-Cas9-induced DNA breaks.

  • Authors : Yuan B; Bioscience Program, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.; Bi C

Subjects: CRISPR-Cas Systems* ; DNA End-Joining Repair* ; Gene Editing*/Gene Editing*/Gene Editing*/methods

  • Source: BMC biology [BMC Biol] 2024 Apr 29; Vol. 22 (1), pp. 101. Date of Electronic Publication: 2024 Apr 29.Publisher: BioMed Central Country of Publication: England NLM ID: 101190720 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7007

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Academic Journal

Fusion of histone variants to Cas9 suppresses non-homologous end joining.

  • Authors : Kato-Inui T; Tokyo Metropolitan Institute of Medical Science, Regenerative Medicine Project, Tokyo, Japan.; Takahashi G

Subjects: Histones*/Histones*/Histones*/metabolism ; Histones*/Histones*/Histones*/genetics ; DNA End-Joining Repair*

  • Source: PloS one [PLoS One] 2024 May 13; Vol. 19 (5), pp. e0288578. Date of Electronic Publication: 2024 May 13 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

How to fix DNA breaks: new insights into the mechanism of non-homologous end joining.

  • Authors : Vogt A; Department of Molecular Biosciences, Northwestern University, Evanston, IL, U.S.A.; Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, IL, U.S.A.

Subjects: DNA-Binding Proteins*/DNA-Binding Proteins*/DNA-Binding Proteins*/metabolism ; DNA End-Joining Repair*; Humans

  • Source: Biochemical Society transactions [Biochem Soc Trans] 2023 Oct 31; Vol. 51 (5), pp. 1789-1800.Publisher: Portland Press On The Behalf Of The Biochemical Society Country of Publication: England NLM ID: 7506897 Publication Model: Print Cited Medium:

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Academic Journal

ZEB1 promotes non-homologous end joining double-strand break repair.

  • Authors : Genetta TL; Dept. of Radiation Oncology, University of Virginia School of Medicine, PO Box 800383, Charlottesville, VA 22908, USA.; Hurwitz JC

Subjects: DNA End-Joining Repair* ; Zinc Finger E-box-Binding Homeobox 1*/Zinc Finger E-box-Binding Homeobox 1*/Zinc Finger E-box-Binding Homeobox 1*/metabolism; BRCA1 Protein/BRCA1 Protein/BRCA1 Protein/genetics

  • Source: Nucleic acids research [Nucleic Acids Res] 2023 Oct 13; Vol. 51 (18), pp. 9863-9879.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Identification and characterization of mercaptopyrimidine-based small molecules as inhibitors of nonhomologous DNA end joining.

  • Authors : Ray U; Department of Biochemistry, Indian Institute of Science, Bangalore, India.; Gopinatha VK

Subjects: DNA End-Joining Repair* ; Neoplasms*/Neoplasms*/Neoplasms*/genetics; Humans

  • Source: The FEBS journal [FEBS J] 2023 Feb; Vol. 290 (3), pp. 796-820. Date of Electronic Publication: 2022 Sep 11.Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication

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Academic Journal

Characterization of sequence contexts that favor alternative end joining at Cas9-induced double-strand breaks.

  • Authors : Hanscom T; Department of Biology, Tufts University, 200 Boston Avenue, Suite 4700, Medford, MA 02155, USA.; Woodward N

Subjects: CRISPR-Cas Systems* ; DNA Breaks, Double-Stranded* ; DNA End-Joining Repair*

  • Source: Nucleic acids research [Nucleic Acids Res] 2022 Jul 22; Vol. 50 (13), pp. 7465-7478.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining.

  • Authors : Head PE; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA.; Kapoor-Vazirani P

Subjects: DNA Breaks, Double-Stranded* ; Protein Kinases*/Protein Kinases*/Protein Kinases*/genetics; DNA/DNA/DNA/genetics

  • Source: Nucleic acids research [Nucleic Acids Res] 2023 Aug 25; Vol. 51 (15), pp. 7972-7987.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

ATM phosphorylates the FATC domain of DNA-PKcs at threonine 4102 to promote non-homologous end joining.

  • Authors : Lu H; Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX75390, USA.; Zhang Q

Subjects: DNA-Activated Protein Kinase*/DNA-Activated Protein Kinase*/DNA-Activated Protein Kinase*/genetics ; Ataxia Telangiectasia*; Humans

  • Source: Nucleic acids research [Nucleic Acids Res] 2023 Jul 21; Vol. 51 (13), pp. 6770-6783.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1.

  • Authors : Oh JM; Center for Genomic Integrity, Institute for Basic Science (IBS), Ulsan 44919, Republic of Korea.; Department of Oral Biochemistry, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea.

Subjects: DNA Repair* ; Exodeoxyribonucleases*/Exodeoxyribonucleases*/Exodeoxyribonucleases*/metabolism ; MutS Homolog 2 Protein*/MutS Homolog 2 Protein*/MutS Homolog 2 Protein*/metabolism

  • Source: Nucleic acids research [Nucleic Acids Res] 2023 Jun 23; Vol. 51 (11), pp. 5584-5602.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Microarray screening reveals two non-conventional SUMO-binding modules linked to DNA repair by non-homologous end-joining.

  • Authors : Cabello-Lobato MJ; Manchester Cancer Research Centre (MCRC), Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, 555 Wilmslow Road, Manchester M20 4GJ, UK.; Jenner M

Subjects: DNA End-Joining Repair* ; DNA Repair*; DNA Breaks, Double-Stranded

  • Source: Nucleic acids research [Nucleic Acids Res] 2022 May 06; Vol. 50 (8), pp. 4732-4754.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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  • 1-10 of  6,006 نتائج ل ""joining""