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Combined inhibition of de novo glutathione and nucleotide biosynthesis is synthetically lethal in glioblastoma

• Authors : Udutha, Suresh; Taglang, Céline; Batsios, Georgios

Subjects: Biochemistry and Cell Biology; Biological Sciences; Brain Cancer

• Source: Cell Reports. 44(5)

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Combined inhibition of HMG-CoA reductase and the renin-angiotensin system attenuates doxorubicin-induced cardiotoxicity in an albino rat model.

• Authors : Marwa, J. Khalil¹ ; Zeina, A. Al-Thanoon²

• Source: Agricultural Biotechnology Journal. 2025, Vol. 17 Issue 3, p219-236. 18p.

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Neuroprotection of photoreceptors by combined inhibition of both Fas and autophagy pathways in P23H mice

• Authors : Mengling Yang; Jingyu Yao; Lin Jia

Subjects: Cytology; QH573-671

• Source: Cell Death and Disease, Vol 16, Iss 1, Pp 1-9 (2025)

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Single Agent and Combined Inhibition After Allogeneic Stem Cell Transplant (CPIT-002)

• Authors : Bristol-Myers Squibb

• Source: Phase I Study of Single-agent and Combined Checkpoint Inhibition After Allogeneic Hematopoietic Stem Cell Transplantation in Patients at

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Combined inhibition of ribonucleotide reductase and WEE1 induces synergistic anticancer activity in Ewing's sarcoma cells.

• Authors : Ziener, Judy^1,2 (AUTHOR); Henao-Restrepo, Julián Andrés³ (AUTHOR); Leonhardi, Johanna^1,2 (AUTHOR)

• Source: BMC Cancer. 2/17/2025, Vol. 25 Issue 1, p1-15. 15p.

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Combined inhibition by PRMT5 and MAT2A demonstrates a strong synthetic lethality in MTAP homozygous-deficient glioma models

• Authors : Zuoyu Jiang; Xuetao Li; Zongyu Xiao

Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; RC254-282; Cytology

• Source: Cell Death Discovery, Vol 11, Iss 1, Pp 1-10 (2025)

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Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage

• Authors : Xue Li; Yao Zhuang; Ya Ru Zhang

Subjects: dopamine receptor inhibitors; monoamine oxidase B; reactive oxygen species

• Source: Frontiers in Behavioral Neuroscience, Vol 19 (2025)

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Combined inhibition of protein kinase B and enhancer of zeste homolog 2: a novel strategy to induce triple-negative breast cancer cell death

• Authors : Xinxiao Zhu; Yongqiang Wang; Long Zhang

Subjects: Medicine

• Source: Molecular Biomedicine, Vol 6, Iss 1, Pp 1-3 (2025)

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Targeting Signaling Excitability in Cervical and Pancreatic Cancer Cells Through Combined Inhibition of FAK and PI3K.

• Authors : Chen, Chao-Cheng¹ (AUTHOR); Wang, Suyang^1,2 (AUTHOR); Yang, Jr-Ming^1,3 (AUTHOR)

• Source: International Journal of Molecular Sciences. Apr2025, Vol. 26 Issue 7, p3040. 16p.

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Targeting CCNE1 amplified ovarian and endometrial cancers by combined inhibition of PKMYT1 and ATR

• Authors : Haineng Xu; Erin George; David Gallo

Subjects: Science

• Source: Nature Communications, Vol 16, Iss 1, Pp 1-19 (2025)

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