نتائج البحث

Blood biomarkers for Alzheimer's disease: Reliable change and impacts of renal and blood–brain barrier function

• Authors : Behrens, Anders; Anderberg, Peter, Professor, 1963; Sanmartin Berglund, Johan, Professor

Subjects: Alzheimer's Disease; Biomarker Validation; Blood Biomarkers

• Source: Alzheimer's and Dementia. 17(3)

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Plasma p-tau181 and GFAP reflect 7T MR-derived changes in Alzheimer’s disease: A longitudinal study of structural and functional MRI and MRS

• Authors : Göschel, Laura; Dell’Orco, Andrea; Fillmer, Ariane

Subjects: Aged; Alzheimer Disease; Amyloid beta-Peptides

• Source: Alzheimer's & Dementia. 20(12):8684-8699

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A network-level transport model of tau progression in the Alzheimer’s brain

• Authors : Tora, Veronica; Torok, Justin; Bertsch, Michiel

Subjects: Applied Mathematics; Mathematical Sciences; Neurodegenerative

• Source: Mathematical Medicine and Biology A Journal of the IMA. 42(2)

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Investigation of the pharmacological activity of the tetrapeptide HAEЕ, zinc, and human serum albumin in a transgenic mouse model with tau protein overexpression (P301S)

• Authors : Veronika S. Shmigerova; Yulia V. Stepenko; Alexandra A. Kurbatova

Subjects: tauopathy; haee-zn-hsa complex pharmaceutical composition; Therapeutics. Pharmacology

• Source: Research Results in Pharmacology, Vol 11, Iss 1, Pp 49-57 (2025)

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A New Strategy in Epilepsy Therapy Through Attenuation of Phosphorylated Tau and Amyloid-beta

• Authors : Junaidi Khotib; Badzlina Azyyati Maizan

Subjects: neurology; seizure; amyloid-beta peptides

• Source: Archives of Epilepsy, Vol 31, Iss 1, Pp 1-5 (2025)

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Retinal ganglion cell vulnerability to pathogenic tau in Alzheimer’s disease

• Authors : Davis, Miyah R; Robinson, Edward; Koronyo, Yosef

Subjects: Biochemistry and Cell Biology; Biological Sciences; Neurosciences

• Source: Acta Neuropathologica Communications. 13(1)

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Geometry based prediction of tau protein sites and motifs associated with misfolding and aggregation

• Authors : Sugiyama, Masumi; Kosik, Kenneth S; Panagiotou, Eleni

Subjects: Biochemistry and Cell Biology; Biological Sciences; Neurodegenerative

• Source: Scientific Reports. 15(1)

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Regulation of tau protein by circCwc27: shared pathogenic mechanisms in type 2 diabetes mellitus and Alzheimer’s disease

• Authors : Keying Fang; Bin Jiao; Lu Shen

Subjects: circCwc27; Alzheimer’s disease; Type 2 diabetes mellitus

• Source: Brain Informatics, Vol 12, Iss 1, Pp 1-13 (2025)

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Obstructive sleep apnea exacerbates cognitive impairment after stroke and the diagnostic value of serum BDNF and Tau protein

• Authors : ZHAO Dongmei, CAO Feihu, WANG Libo, HUANG Jun, DU Yuxin, LIU Qian

Subjects: obstructive sleep apnea; stroke; cognitive impairment

• Source: Jichu yixue yu linchuang, Vol 45, Iss 9, Pp 1195-1199 (2025)

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Spatiotemporal characterization of cellular tau pathology in the human locus coeruleus–pericoerulear complex by three-dimensional imaging

• Authors : Gilvesy, A.; Husen, E.; Magloczky, Z.

Subjects: Alzheimer’s disease; Locus coeruleus; Tau pathology

• Source: Acta Neuropathologica. 144(4):651-676

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Antioxidative effects of phytoaromatic compounds on the cysteine of the SKCGS peptide as a critical aggregation domain of tau

• Authors : Afsaneh Roshanfekr; Zahra Moeini; Farhad Golmohammadi

Subjects: Oxidative stress; Disulfide bond; SKCGS peptide

• Source: Scientific Reports, Vol 15, Iss 1, Pp 1-16 (2025)

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Modulation of neuronal α1-adrenergic receptor reduces tauopathy and neuroinflammation by inhibiting the STING/NF-κB/NLRP3 signaling pathway in Alzheimer’s disease mice

• Authors : Bo Li; Li Wang; Yan Xiao

Subjects: ADRA1; CXCR4; Sting

• Source: Journal of Neuroinflammation, Vol 22, Iss 1, Pp 1-25 (2025)

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A systematic review of Alzheimer's disease: exploring genetic and environmental risk factors, biomarkers, and future pharmacotherapy for cognitive decline and neurodegeneration

• Authors : Debraj Dey; Deepannita Roy Mukherjee; Abu Shoeb

Subjects: cholinergic neurodegeneration; memory impairment; synaptic dysfunction

• Source: Journal of Applied Pharmaceutical Research, Vol 13, Iss 3, Pp 17-35 (2025)

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New Possibilities for Evaluating Markers of Alzheimer's Disease in Blood Serum

• Authors : S. V. Vorobev; A. Yu. Plekhanov; I. K. Ternovykh

Subjects: graphene; biosensor; alzheimer's disease

• Source: Антибиотики и Химиотерапия, Vol 70, Iss 1-2, Pp 20-28 (2025)

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Piper Longum's Neuroprotective Role Against Amyloid-β and Okadaic Acid-Induced Toxicity in U87MG Cells Through the Lipocalin-2 Pathway

• Authors : Seok-Hwan Sung; Seung-Min Shin; Yunna Kim

Subjects: alzheimer's disease; amyloid β; astrocyte

• Source: Journal of Pharmacopuncture, Vol 28, Iss 2, Pp 92-99 (2025)

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Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life

• Authors : Valentina Latina; Margherita De Introna; Francesca Malerba

Subjects: Alzheimer’s Disease (AD); Tau protein; Amyloid beta (Aβ)

• Source: Acta Neuropathologica Communications, Vol 13, Iss 1, Pp 1-31 (2025)

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Alzheimer’s Disease: The Impact of Gut Microbiota and Sex Differences on Pathogenesis and Treatment Strategies

• Authors : Kh. A. Abdel-Sater

Subjects: alzheimer’s disease; gut microbiota; sex differences

• Source: Архивъ внутренней медицины, Vol 15, Iss 3, Pp 165-177 (2025)

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Effect of PHF-1 hyperphosphorylation on the seeding activity of C-terminal Tau fragments

• Authors : El Hajjar, Léa; Boll, Emmanuelle; Cantrelle, François-Xavier ...

Subjects: [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology; Glycogen Synthase Kinase 3 beta; microtubule-associated Tau protein

• Source: Sci RepScientific Reports, Vol 15, Iss 1, Pp 1-16 (2025)

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Bridging prion biology and Alzheimer’s disease: from pathogenic seeds to precision therapeutics

• Authors : Wenjin Wang; Zhanhui Feng; Lingfeng Shu

Subjects: Alzheimer’s disease; amyloid-beta; tau protein

• Source: Frontiers in Molecular Neuroscience, Vol 18 (2025)

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Evaluation of the diagnostic efficacy of core biomarkers in cerebrospinal fluid for Alzheimer’s disease: a systematic review and meta-analysis

• Authors : Baohua Deng; Yangtai Zheng; Yiyang Gao

Subjects: Bayesian meta-analysis; Alzheimer’s disease; core cerebrospinal fluid biomarkers

• Source: Frontiers in Neurology, Vol 16 (2025)

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Concentration‐Based Analysis of Metal‐Induced Tau Fibrillar versus non‐fibrillar Aggregation: Implications for Neurotoxicity in Alzheimer's Disease

• Authors : Mahzad Irandoust; Afrooz Anbaraki; Zahra Dindar

Subjects: Metal ions; Tau protein; Fibrillation

• Source: ChemistryOpen, Vol 14, Iss 8, Pp n/a-n/a (2025)

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Relationship of C-reactive protein and Tau protein serum levels during ischemic stroke

• Authors : Joanna Bielewicz; Beata Daniluk; Michał J. Sekuła

Subjects: c-reactive protein; tau protein; ischemic stroke

• Source: Studia Medyczne, Vol 41, Iss 2, Pp 103-109 (2025)

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Optical signature of retinal Tau fibrillation

• Authors : Zita Salajková; Lorenzo Barolo; Paola Baiocco

Subjects: Tau protein; Protein fibrillation monitoring; Alzheimer’s disease

• Source: Scientific Reports, Vol 15, Iss 1, Pp 1-12 (2025)

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Impact of hyaluronic acid-modified hafnium metalorganic frameworks containing rhynchophylline on Alzheimer’s disease

• Authors : Lin Shiguo; Ye Yanshan; Lin Sujin

Subjects: neurodegenerative disorder; alzheimer’s disease; amyloid beta

• Source: Open Life Sciences, Vol 20, Iss 1, Pp 609-22 (2025)

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The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer's disease animal model

• Authors : Nurina Titisari; Hafandi Ahmad; Nurdiana Samsulrizal

Subjects: beta-amyloid; brain; hyperglycemia

• Source: Open Veterinary Journal, Vol 15, Iss 2, Pp 594-600 (2025)

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Temperature-Dependent Aggregation of Tau Protein Is Attenuated by Native PLGA Nanoparticles Under in vitro Conditions

• Authors : Paul PS; Rathnam M; Khalili A

Subjects: tau protein; plga nanoparticles; tau pathology

• Source: International Journal of Nanomedicine, Vol 20, Pp 1999-2019 (2025)

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Neuronal Excitation Induces Tau Protein Dephosphorylation via Protein Phosphatase 1 Activation to Promote Its Binding with Stable Microtubules

• Authors : Sosuke Yagishita; Megumi Shibata; Akiko Furuno

Subjects: 0301 basic medicine; 0303 health sciences; phosphorylation

• Source: Neurol IntNeurology International, Vol 16, Iss 3, Pp 653-662 (2024)

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Structural and biochemical differences between non-catalytic and catalytic antibodies

• Authors : Taizo Uda; Ryuichi Kato; Yasuteru Shigeta

Subjects: Catalytic antibody; pro95 residue deletion; amyloid-beta

• Source: mAbs, Vol 17, Iss 1 (2025)

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Animal models of tau propagation in Alzheimer's disease

• Authors : Masami Masuda-Suzukake; Shotaro Shimonaka; Takashi Nonaka

Subjects: Alzheimer’s disease; Tau protein; Model animals

• Source: Neuroscience Research, Vol 220, Iss , Pp 104960- (2025)

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In-vivo neuronal dysfunction by Aβ and tau overlaps with brain-wide inflammatory mechanisms in Alzheimer’s disease

• Authors : Sanchez-Rodriguez, Lazaro M; Khan, Ahmed F; Adewale, Quadri

Subjects: Biological Psychology; Biomedical and Clinical Sciences; Neurosciences

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Association of Loneliness with Functional Connectivity MRI, Amyloid-β PET, and Tau PET Neuroimaging Markers of Vulnerability for Alzheimers Disease.

• Authors : Zhao, Amanda; Balcer, Laura; Himali, Jayandra

Subjects: Alzheimer’s disease; amyloid; dementia

• Source: Journal of Alzheimers Disease. 99(4)

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Alzheimer’s Disease in the Context of an Aging Society: Challenges and Future Directions

• Authors : Aleksandra Boral; Bartłomiej Czarnecki; Wiktoria Pniok

Subjects: Alzheimer’s disease; amyloid-β; tau protein

• Source: Journal of Education, Health and Sport, Vol 83 (2025)

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Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology

• Authors : Vipul Sharma; Khadga Raj Aran

Subjects: Alzheimer's disease; Vitamin; Tau protein

• Source: Aging and Health Research, Vol 5, Iss 2, Pp 100226- (2025)

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Diffusion tensor imaging of sequential neuropathological patterns in progressive supranuclear palsy

• Authors : Lavinia A. Bârlescu; Günter U. Höglinger; Heiko Volkmann

Subjects: progressive supranuclear palsy; sequential pattern; diffusion tensor imaging (DTI)

• Source: Frontiers in Aging Neuroscience, Vol 17 (2025)

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CTE in Athletes: Understanding the Long-Term Effects of Repetitive Head Injuries

• Authors : Weronika Sepioło; Mikołaj Lewandoswki; Zofia Kwiatkowska

Subjects: CTE in athletes; repetitive head impacts; tau protein

• Source: Quality in Sport, Vol 41 (2025)

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Picomolar Detection of Tau Protein Using 1D Photonic Crystal Biochips for Alzheimer's Disease Diagnosis

• Authors : Alberto Sinibaldi; Francesco Chiavaioli; Agostino Occhicone

Subjects: 1D photonic crystals; Alzheimer's disease; biophotonic platform

• Source: Advanced Sensor Research, Vol 4, Iss 5, Pp n/a-n/a (2025)

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Cerebrospinal Fluid Proteins Altered in Corticobasal Degeneration

• Authors : Paslawski, W.; Bergström, Sofia; Zhang, X.

Subjects: alpha 1 antichymotrypsin; camp regulated phosphoprotein 21; CD14 antigen

• Source: Movement Disorders. 36(5):1278-1280

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Distribution of β-amyloid and pTau in brain cortex depending on age and mental state

• Authors : Alexandra V. Sentyabreva; Olyesya A. Vasyukova; Yana A. Zorkina

Subjects: alzheimer’s disease; β-amyloid; tau-protein

• Source: RUDN Journal of Medicine, Vol 28, Iss 4, Pp 488-498 (2024)

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A case report of fatal familial insomnia with cerebrospinal fluid leukocytosis during the COVID-19 epidemic and review of the literature

• Authors : Zheng Wang; Yueqi Huang; Shuqi Wang

Subjects: Clinical features; CSF analysis; fatal family insomnia

• Source: Prion, Vol 18, Iss 1, Pp 1-10 (2024)

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Effects of CREB and miR-132-3p on aluminum-induced abnormal phosphorylation of tau protein in rat hippocampus

• Authors : Wenjie XIAO; Xu XU; Minmin LEI

Subjects: aluminum; mir-132-3p; cyclic amp response element binding protein

• Source: 环境与职业医学, Vol 41, Iss 11, Pp 1270-1276 (2024)

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Tau-Targeted Therapeutic Strategies: Mechanistic Targets, Clinical Pipelines, and Analysis of Failures

• Authors : Xinai Shen; Huan Li; Beiyu Zhang

Subjects: tau protein; Alzheimer’s disease; tauopathies

• Source: Cells, Vol 14, Iss 19, p 1506 (2025)

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Hyperphosphorylated Tau Induces Cortical Hypoexcitability in Transgenic Mouse Models: A Meta-Analysis

• Authors : Carlos A García-Carlos; Gustavo Basurto-Islas; George Perry

Subjects: alzheimer’s disease; cerebral cortex; tau protein

• Source: Journal of Integrative Neuroscience, Vol 24, Iss 8, p 39192 (2025)

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Secondary structures transition of tau protein with intrinsically disordered proteins specific force field.

• Authors : Dan, Aohuan¹; Chen, Hai‐Feng^1,2

• Source: Chemical Biology & Drug Design. Mar2019, Vol. 93 Issue 3, p242-253. 12p.

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Conformational stability assay (CSA) results on brain-derived, detergent-insoluble tau aggregates in all AD cases used in the study.

• Authors : Lenka Hromadkova; Chae Kim; Tracy Haldiman

Subjects: Biophysics; Biochemistry; Neuroscience

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Summary data on primary mouse neuron cultures and neuronally differentiated SH-SY5Y cells exposed to AD brain-derived tau conformers.

• Authors : Lenka Hromadkova; Chae Kim; Tracy Haldiman

Subjects: Biophysics; Biochemistry; Neuroscience

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Case information for all samples used in the study.

• Authors : Lenka Hromadkova; Chae Kim; Tracy Haldiman

Subjects: Biophysics; Biochemistry; Neuroscience

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Hydroxylation half-life of different microtubule binding domains (MTBDs) and C-terminal tail monitored in insoluble AD brain-derived tau conformers in all AD cases used in the study.

• Authors : Lenka Hromadkova; Chae Kim; Tracy Haldiman

Subjects: Biophysics; Biochemistry; Neuroscience

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Enhanced fluorescence detection of tau protein using photonic crystal-based biochips: a novel tool for Alzheimer's disease diagnostics

• Authors : Sinibaldi, Alberto; Chiavaioli, Francesco; Occhicone, Agostino ...

Subjects: Alzheimer; tau protein; biosensor

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Taming amyloid oligomers:Developing analytical approaches to investigate peptide aggregation

• Authors : Stroganova, Iuliia

Subjects: aggregation; mass spectrometry; ion mobility

• Source: Stroganova , I 2025 , ' Taming amyloid oligomers : Developing analytical approaches to investigate peptide aggregation ' , PhD , Vrije Universiteit Amsterdam . https://doi.org/10.5463/thesis.953

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Effects of a Garlic Hydrophilic Extract Rich in Sulfur Compounds on Redox Biology and Alzheimer's Disease Markers in Caenorhabditis Elegans

• Authors : María D. Navarro‐Hortal; Jose M. Romero‐Marquez; Johura Ansary

Subjects: acetylcholinesterase; aging; amyloid

• Source: eFood, Vol 6, Iss 2, Pp n/a-n/a (2025)

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