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Biophysical and Functional Characterization of a Thermally Stable Bifunctional Serine Protease Inhibitor from Cleome viscosa Seeds.

• Authors : Radhakrishnan M; Center of Advanced Study in Crystallography & Biophysics, University of Madras, Chennai 600025, India.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Subjects: Serine Proteinase Inhibitors*/Serine Proteinase Inhibitors*/Serine Proteinase Inhibitors*/chemistry ; Serine Proteinase Inhibitors*/Serine Proteinase Inhibitors*/Serine Proteinase Inhibitors*/pharmacology ; Serine Proteinase Inhibitors*/Serine Proteinase Inhibitors*/Serine Proteinase Inhibitors*/isolation & purification

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 Dec 05; Vol. 26 (24). Date of Electronic Publication: 2025 Dec 05.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Mechanistic and Kinetic Insights into the Acylation Reaction of Hepatitis C Virus NS3/NS4A Serine Protease with NS4B/5A Substrate.

• Authors : Martínez-González JÁ; Departamento de Química y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28668 Madrid, Spain.; Departamento de Química, Universidad de La Rioja, C/Madre de Dios, 51, 26006 Logroño, Spain.

Subjects: Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/metabolism ; Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/chemistry ; Hepacivirus*/Hepacivirus*/Hepacivirus*/enzymology

• Source: Biomolecules [Biomolecules] 2025 Nov 18; Vol. 15 (11). Date of Electronic Publication: 2025 Nov 18.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X

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Comprehensive Analysis of the Putative Substratome of FAM20C, the Master Serine Kinase of the Secretory Pathway.

• Authors : Cesaro, Luca¹ (AUTHOR); Noventa, Francesca^1,2 (AUTHOR); De Los Angeles Cordero, Trinidad¹ (AUTHOR)

• Source: Biomolecules (2218-273X). Nov2025, Vol. 15 Issue 11, p1582. 17p.

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Trichinella spiralis serine protease mediates larval invasion of gut epithelium via binding to CK8 and activating RhoA/ROCK1 pathway.

• Authors : Zheng, Wen Wen¹ (AUTHOR); Zhang, Xin Zhuo¹ (AUTHOR); Cong, Pei Kun¹ (AUTHOR)

• Source: PLoS Neglected Tropical Diseases. 11/13/2025, Vol. 19 Issue 11, p1-33. 33p.

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Serine/Threonine Kinase 33 as a Novel Target of Bufalin in Treatment of Triple‐Negative Breast Cancer.

• Authors : Jiang, Shilong^1,2,3 (AUTHOR); Liu, Junyan⁴ (AUTHOR); Li, Hui⁵ (AUTHOR)

• Source: Advanced Science. 11/6/2025, Vol. 12 Issue 41, p1-17. 17p.

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PRSS38 Is a Novel Sperm Serine Protease Involved in Human and Mouse Fertilization.

• Authors : Manjon AA; Laboratorio de Estudios de Interacción Celular en Reproducción y Cáncer, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490, Buenos Aires C1428ADN, Argentina.; Verón GL

Subjects: Spermatozoa*/Spermatozoa*/Spermatozoa*/enzymology ; Spermatozoa*/Spermatozoa*/Spermatozoa*/metabolism ; Serine Proteases*/Serine Proteases*/Serine Proteases*/metabolism

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 Dec 02; Vol. 26 (23). Date of Electronic Publication: 2025 Dec 02.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Skullcapflavone II Inhibits SLC1A4-Mediated L-Serine Uptake and Promotes Mitochondrial Damage in Gastric Cancer.

• Authors : Zhao J; Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer, Zhejiang Cancer Hospital, Hangzhou, 310022, China.; Zhejiang Key Lab of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer, Zhejiang Cancer Hospital, Hangzhou, 310022, China.

Subjects: Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/metabolism ; Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/drug therapy ; Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/pathology

• Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Dec; Vol. 12 (45), pp. e17225. Date of Electronic Publication: 2025 Sep 19.Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844

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Enhanced l-serine synthesis in Corynebacterium glutamicum by exporter engineering and Bayesian optimization of the medium composition

• Authors : Yifan Huang; Yujie Gao; Yamin Huang

Subjects: Corynebacterium glutamicum; l-serine; Semi-rational design

• Source: Synth Syst BiotechnolSynthetic and Systems Biotechnology, Vol 10, Iss 3, Pp 835-845 (2025)

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Comparative immunodiagnostic evaluation of recombinant serine proteases from Trichinella spiralis and Trichinella nativa for early detection of trichinellosis.

• Authors : Zhumalin, Aibek¹ ; Gajimuradova, Aisarat² ; Bulashev, Aitbay³

• Source: Veterinary World. Oct2025, Vol. 18 Issue 10, p3243-3254. 12p.

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Perturbations in L-serine metabolism regulate protein quality control through the sensor of the retrograde response pathway RTG2 in Saccharomyces cerevisiae

• Authors : Saxena, Kanika; Andersson, Rebecca; Widlund, Per O.

Subjects: retrograde response; aggregation; serine

• Source: Journal of Biological Chemistry. 301(7)

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