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Academic Journal

Structural basis for LZTR1 recognition of RAS GTPases for degradation.

Authors : Dharmaiah S; National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.; Bonsor DA

Subjects: Proteolysis* ; Proto-Oncogene Proteins p21(ras)*/Proto-Oncogene Proteins p21(ras)*/Proto-Oncogene Proteins p21(ras)*/chemistry ; Proto-Oncogene Proteins p21(ras)*/Proto-Oncogene Proteins p21(ras)*/Proto-Oncogene Proteins p21(ras)*/metabolism

Source: Science (New York, N.Y.) [Science] 2025 Sep 11; Vol. 389 (6765), pp. 1112-1117. Date of Electronic Publication: 2025 Sep 11.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Academic Journal

Expression profiling of KRAS and NOXA genes as prospective biomarkers in ovarian carcinoma.

Authors : Abdelnaeem K; Molecular Biotechnology Sector, Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt.; Dawood RM

Subjects: Ovarian Neoplasms*/Ovarian Neoplasms*/Ovarian Neoplasms*/genetics ; Ovarian Neoplasms*/Ovarian Neoplasms*/Ovarian Neoplasms*/pathology ; Ovarian Neoplasms*/Ovarian Neoplasms*/Ovarian Neoplasms*/metabolism

Source: Scientific reports [Sci Rep] 2025 Sep 05; Vol. 15 (1), pp. 32370. Date of Electronic Publication: 2025 Sep 05.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

KRAS/ABHD17C/ALOX15B Axis Promotes Pancreatic Cancer Progression via Ferroptosis Evasion.

Authors : Li M; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510080, China.; Department of Biochemistry, Zhongshan School of Medicine Sun Yat-sen University, Guangzhou, 510080, China.

Subjects: Ferroptosis*/Ferroptosis*/Ferroptosis*/genetics ; Proto-Oncogene Proteins p21(ras)*/Proto-Oncogene Proteins p21(ras)*/Proto-Oncogene Proteins p21(ras)*/genetics ; Proto-Oncogene Proteins p21(ras)*/Proto-Oncogene Proteins p21(ras)*/Proto-Oncogene Proteins p21(ras)*/metabolism

Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Sep; Vol. 12 (35), pp. e04470. Date of Electronic Publication: 2025 Jun 26.Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844

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Academic Journal

The FGFR inhibitor pemigatinib overcomes cancer drug resistance to KRAS G12C inhibitors in mesenchymal lung cancer.

Authors : Abdollahi A; Incyte Research Institute, Wilmington, Delaware, United States of America.; Favata M

Subjects: Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/drug therapy ; Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/genetics ; Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/pathology

Source: PloS one [PLoS One] 2025 Aug 11; Vol. 20 (8), pp. e0327588. Date of Electronic Publication: 2025 Aug 11 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Daraxonrasib, a pan-RAS inhibitor, selectively inhibits osteosarcomas with activated KRAS by halting AKT signaling and matrix metalloprotease activity.

Authors : Jung O; Department of Medical Laboratory Sciences, Hunter College, City University of New York, New York, New York, United States of America.; Ph.D. Program in Biology (Molecular, Cellular, and Developmental Biology Sub-Program), The Graduate Center of the City University of New York, New York, New York, United States of America.

Subjects: Osteosarcoma*/Osteosarcoma*/Osteosarcoma*/drug therapy ; Osteosarcoma*/Osteosarcoma*/Osteosarcoma*/pathology ; Osteosarcoma*/Osteosarcoma*/Osteosarcoma*/metabolism

Source: PloS one [PLoS One] 2025 Aug 08; Vol. 20 (8), pp. e0329946. Date of Electronic Publication: 2025 Aug 08 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Mechanistic Foundations of KRAS-Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment.

Authors : Ma J; Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; Fu S

Subjects: Tumor Microenvironment*/Tumor Microenvironment*/Tumor Microenvironment*/immunology ; Tumor Microenvironment*/Tumor Microenvironment*/Tumor Microenvironment*/genetics ; Proto-Oncogene Proteins p21(ras)*/Proto-Oncogene Proteins p21(ras)*/Proto-Oncogene Proteins p21(ras)*/genetics

Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Aug; Vol. 12 (30), pp. e02714. Date of Electronic Publication: 2025 Jun 09.Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844

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Academic Journal

An Engineered Soluble Single-Chain TCR Engager for KRAS-G12V Specific Tumor Immunotherapy.

Authors : Ma K; Department of Infectious Diseases, Shenzhen Children's Hospital, Shenzhen, 518026, China.; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.

Subjects: Receptors, Antigen, T-Cell*/Receptors, Antigen, T-Cell*/Receptors, Antigen, T-Cell*/genetics ; Receptors, Antigen, T-Cell*/Receptors, Antigen, T-Cell*/Receptors, Antigen, T-Cell*/immunology ; Immunotherapy*/Immunotherapy*/Immunotherapy*/methods

Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Aug; Vol. 12 (31), pp. e00181. Date of Electronic Publication: 2025 Jun 05.Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844

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Academic Journal

A neomorphic protein interface catalyzes covalent inhibition of RAS G12D aspartic acid in tumors.

Authors : Weller C; Revolution Medicines, Inc., Redwood City, CA, USA.; Burnett GL

Subjects: Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemistry ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/therapeutic use

Source: Science (New York, N.Y.) [Science] 2025 Jul 24; Vol. 389 (6758), pp. eads0239. Date of Electronic Publication: 2025 Jul 24.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Academic Journal

The Impact of Fusobacterium nucleatum and the Genotypic Biomarker KRAS on Colorectal Cancer Pathogenesis.

Authors : Dewan A; College of Life Sciences, Anhui Agriculture University, Hefei 230036, China.; Tattoli I

Subjects: Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/genetics ; Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/microbiology ; Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/pathology

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Jul 20; Vol. 26 (14). Date of Electronic Publication: 2025 Jul 20.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Investigation of potential KRASG12D inhibitors: a comparative study between MRTX1133 and natural compounds via computational structural biology approaches.

Authors : Bostancioglu SM; Department of Biology, Faculty of Arts and Sciences, Marmara University, Goztepe Campus, Goztepe, Istanbul, 34722, Turkey. .; Acar A

Subjects: Proto-Oncogene Proteins p21(ras)*/Proto-Oncogene Proteins p21(ras)*/Proto-Oncogene Proteins p21(ras)*/antagonists & inhibitors ; Proto-Oncogene Proteins p21(ras)*/Proto-Oncogene Proteins p21(ras)*/Proto-Oncogene Proteins p21(ras)*/genetics ; Proto-Oncogene Proteins p21(ras)*/Proto-Oncogene Proteins p21(ras)*/Proto-Oncogene Proteins p21(ras)*/chemistry

Source: BMC research notes [BMC Res Notes] 2025 Jul 12; Vol. 18 (1), pp. 287. Date of Electronic Publication: 2025 Jul 12.Publisher: Biomed Central Country of Publication: England NLM ID: 101462768 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-0500

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نتائج البحث

فلترة النتائج

Structural basis for LZTR1 recognition of RAS GTPases for degradation.

Expression profiling of KRAS and NOXA genes as prospective biomarkers in ovarian carcinoma.

KRAS/ABHD17C/ALOX15B Axis Promotes Pancreatic Cancer Progression via Ferroptosis Evasion.

The FGFR inhibitor pemigatinib overcomes cancer drug resistance to KRAS G12C inhibitors in mesenchymal lung cancer.

Daraxonrasib, a pan-RAS inhibitor, selectively inhibits osteosarcomas with activated KRAS by halting AKT signaling and matrix metalloprotease activity.

Mechanistic Foundations of KRAS-Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment.

An Engineered Soluble Single-Chain TCR Engager for KRAS-G12V Specific Tumor Immunotherapy.

A neomorphic protein interface catalyzes covalent inhibition of RAS G12D aspartic acid in tumors.

The Impact of Fusobacterium nucleatum and the Genotypic Biomarker KRAS on Colorectal Cancer Pathogenesis.

Investigation of potential KRASG12D inhibitors: a comparative study between MRTX1133 and natural compounds via computational structural biology approaches.

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