نتائج البحث

9,10-Dioxoanthracenyldithiocarbamates effectively inhibit the proliferation of non-small cell lung cancer by targeting multiple protein tyrosine kinases.

• Authors : Olszewski M; Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Gdansk, Poland.; Stasevych M

Subjects: Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/drug therapy ; Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/metabolism ; Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/drug therapy

• Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2024 Dec; Vol. 39 (1), pp. 2284113. Date of Electronic Publication: 2023 Dec 11.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Inhibition of FOXM1 Leads to Suppression of Cell Proliferation, Migration, and Invasion Through AXL/eEF2 Kinase Signaling and Induces Apoptosis and Ferroptosis in GBM Cells.

• Authors : Biltekin E; Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA.; Department of Biomedical Engineering, University of Houston, Houston, TX 77004, USA.

Subjects: Forkhead Box Protein M1*/Forkhead Box Protein M1*/Forkhead Box Protein M1*/metabolism ; Forkhead Box Protein M1*/Forkhead Box Protein M1*/Forkhead Box Protein M1*/genetics ; Forkhead Box Protein M1*/Forkhead Box Protein M1*/Forkhead Box Protein M1*/antagonists & inhibitors

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 Jul 15; Vol. 26 (14). Date of Electronic Publication: 2025 Jul 15.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD.

• Authors : Clelland CD; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA. .; Memory & Aging Center, Department of Neurology, University of California San Francisco, San Francisco, California, USA. .

Subjects: c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/genetics ; c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/c-Mer Tyrosine Kinase*/metabolism ; Progranulins*/Progranulins*/Progranulins*/genetics

• Source: Communications biology [Commun Biol] 2025 Jul 01; Vol. 8 (1), pp. 971. Date of Electronic Publication: 2025 Jul 01.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Macrophage WEE1 Directly Binds to and Phosphorylates NF-κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis.

• Authors : Huang Z; Department of Pharmacy and Institute of Inflammation, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 310014, China.; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 311000, China.

Subjects: Macrophages*/Macrophages*/Macrophages*/metabolism ; Atherosclerosis*/Atherosclerosis*/Atherosclerosis*/metabolism ; Atherosclerosis*/Atherosclerosis*/Atherosclerosis*/genetics

• Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Jul; Vol. 12 (26), pp. e2503192. Date of Electronic Publication: 2025 Apr 09.Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844

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MPS1 promotes timely spindle bipolarization to prevent kinetochore-microtubule attachment errors in oocytes.

• Authors : Yoshida S; Laboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Japan. .; Nakagawa R

Subjects: Kinetochores*/Kinetochores*/Kinetochores*/metabolism ; Oocytes*/Oocytes*/Oocytes*/metabolism ; Oocytes*/Oocytes*/Oocytes*/cytology

• Source: The EMBO journal [EMBO J] 2025 Jul; Vol. 44 (13), pp. 3794-3823. Date of Electronic Publication: 2025 Jun 04.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Synergistic MDM2-STAT3 Inhibition Demonstrates Strong Anti-Leukemic Efficacy in Acute Lymphoblastic Leukemia.

• Authors : Aptullahoglu, Erhan^1,2 (AUTHOR) ; Kaygusuz, Emrah^1,2 (AUTHOR)

Subjects: *Lymphoblastic leukemia; *p53 protein; *Cancer treatment

• Source: International Journal of Molecular Sciences. Sep2025, Vol. 26 Issue 17, p8648. 25p.

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Polystyrene Nanoparticles-coated Astragalus Polysaccharides Affects the Development of Prostate Cancer by Regulating Glycolysis of DAP12/SYK Axis through miR-370.

• Authors : Gao, Cheng¹ (AUTHOR); Liu, Zixiong² (AUTHOR); Tan, Jiafu³ (AUTHOR)

• Source: Pharmacognosy Magazine. Sep2025, Vol. 21 Issue 3, p974-983. 10p.

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Immunophenotyping identifies key immune biomarkers for coronary artery disease through machine learning.

• Authors : Jiang, Lelin¹ (AUTHOR); Jiang, Minghao² (AUTHOR); Liu, Yiying³ (AUTHOR)

Subjects: *Coronary artery disease; *Biomarkers; *Protein-tyrosine kinases

• Source: PLoS ONE. 8/26/2025, Vol. 20 Issue 8, p1-23. 23p.

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Src Reduces Neutrophil Extracellular Traps Generation and Resolves Acute Organ Damage.

• Authors : Lu, Guotao^1,2 (AUTHOR); Han, Fei^1,2 (AUTHOR); Wang, Yaodong³ (AUTHOR)

• Source: Advanced Science. Aug2025, p1. 15p. 7 Illustrations.

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Increasing lipid accumulation in Chlamydomonas by serial knocking out of DYRKP1 kinase and ADP-glucose pyrophosphorylase.

• Authors : Kim, Minjae¹ (AUTHOR) ; Kim, Ji Yeon¹ (AUTHOR); Han, Kyong Ha² (AUTHOR)

Subjects: *Chlamydomonas; *Microalgae; *Protein-tyrosine kinases

• Source: Microbial Cell Factories. 8/22/2025, Vol. 24 Issue 1, p1-10. 10p.

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