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Rational Design of Chimeric Antisense Oligonucleotides on a Mixed PO-PS Backbone for Splice-Switching Applications.

• Authors : Le BT; Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia.; ProGenis Pharmaceuticals Pty Ltd., Bentley, WA 6102, Australia.

Subjects: Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/chemistry ; Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/Oligonucleotides, Antisense*/genetics ; RNA Splicing*

• Source: Biomolecules [Biomolecules] 2024 Jul 22; Vol. 14 (7). Date of Electronic Publication: 2024 Jul 22.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X

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G4-Ligand-Conjugated Oligonucleotides Mediate Selective Binding and Stabilization of Individual G4 DNA Structures

• Authors : Berner, A; Das, RN; Bhuma, N

Subjects: Medicin och hälsovetenskap

• Source: Journal of the American Chemical Society. 146(10):6926-6935

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Allele-Selective Thiomorpholino Antisense Oligonucleotides as a Therapeutic Approach for Fused-in-Sarcoma Amyotrophic Lateral Sclerosis.

• Authors : Mejzini, Rita^1,2 (AUTHOR) ; Caruthers, Marvin H.³ (AUTHOR) ; Schafer, Balazs³ (AUTHOR)

• Source: International Journal of Molecular Sciences. Aug2024, Vol. 25 Issue 15, p8495. 20p.

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Potential of Cell-Penetrating Peptide-Conjugated Antisense Oligonucleotides for the Treatment of SMA.

• Authors : Leckie J; Department of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.; Yokota T

Subjects: Cell-Penetrating Peptides*/Cell-Penetrating Peptides*/Cell-Penetrating Peptides*/chemistry ; Cell-Penetrating Peptides*/Cell-Penetrating Peptides*/Cell-Penetrating Peptides*/pharmacology ; Muscular Atrophy, Spinal*/Muscular Atrophy, Spinal*/Muscular Atrophy, Spinal*/drug therapy

• Source: Molecules (Basel, Switzerland) [Molecules] 2024 Jun 04; Vol. 29 (11). Date of Electronic Publication: 2024 Jun 04.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Introduction of sugar-modified nucleotides into CpG-containing antisense oligonucleotides inhibits TLR9 activation.

• Authors : Yoshida, Tokuyuki^1,2 (AUTHOR); Hagihara, Tomoko³ (AUTHOR); Uchida, Yasunori¹ (AUTHOR)

• Source: Scientific Reports. 5/21/2024, Vol. 11 Issue 1, p1-9. 9p.

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Antisense Oligonucleotides (ASOs) in Motor Neuron Diseases: A Road to Cure in Light and Shade.

• Authors : Cantara, Silvia¹ (AUTHOR) ; Simoncelli, Giorgia² (AUTHOR) ; Ricci, Claudia¹ (AUTHOR)

Subjects: *MOTOR neuron diseases; *SPINAL muscular atrophy; *AMYOTROPHIC lateral sclerosis

• Source: International Journal of Molecular Sciences. May2024, Vol. 25 Issue 9, p4809. 25p.

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A novel transient receptor potential C3/C6 selective activator induces the cellular uptake of antisense oligonucleotides.

• Authors : Kohashi, Hiroto¹ (AUTHOR); Nagata, Ryu¹ (AUTHOR) ; Tamenori, Yusuke² (AUTHOR)

Subjects: *OLIGONUCLEOTIDES; *DRUG delivery systems; *DEXTRAN

• Source: Nucleic Acids Research. 5/22/2024, Vol. 52 Issue 9, p4784-4798. 15p.

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Phosphoramidate Azole Oligonucleotides for Single Nucleotide Polymorphism Detection by PCR.

• Authors : Chubarov, Alexey S.¹ (AUTHOR) ; Baranovskaya, Elizaveta E.¹ (AUTHOR); Oscorbin, Igor P.¹ (AUTHOR)

Subjects: *SINGLE nucleotide polymorphisms; *DNA primers; *OLIGONUCLEOTIDES

• Source: International Journal of Molecular Sciences. Jan2024, Vol. 25 Issue 1, p617. 16p.

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Influence of Combinations of Lipophilic and Phosphate Backbone Modifications on Cellular Uptake of Modified Oligonucleotides.

• Authors : Zharkov, Timofey D.¹ (AUTHOR); Markov, Oleg V.¹ (AUTHOR); Zhukov, Sergey A.¹ (AUTHOR)

Subjects: *OLIGONUCLEOTIDES; *PHOSPHATES; *DNA synthesis

• Source: Molecules. Jan2024, Vol. 29 Issue 2, p452. 16p.

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Non-Targeted Detection of Synthetic Oligonucleotides in Equine Serum Using Liquid Chromatography–High-Resolution Mass Spectrometry.

• Authors : Helmes, Emily¹ (AUTHOR) ; Montgomery, Jacob¹ (AUTHOR) ; Alarcio, Gwendolyne¹ (AUTHOR)

Subjects: *MASS spectrometry; *OLIGONUCLEOTIDES; *NUCLEOTIDE sequence

• Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 11, p5752. 15p.

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