نتائج البحث

Microsatellite instability in mismatch repair proficient colorectal cancer: clinical features and underlying molecular mechanisms.

• Authors : Xu, Yun; Liu, Kai; Li, Cong

Subjects: Colorectal cancer; Diagnostic biomarker; Microsatellite instability

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PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability.

• Authors : Tejwani V; MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, DD1 5EH, UK.; Carroll T

Subjects: Werner Syndrome Helicase*/Werner Syndrome Helicase*/Werner Syndrome Helicase*/metabolism ; Werner Syndrome Helicase*/Werner Syndrome Helicase*/Werner Syndrome Helicase*/genetics ; Microsatellite Instability*/Microsatellite Instability*/Microsatellite Instability*/drug effects

• Source: Scientific reports [Sci Rep] 2024 Sep 06; Vol. 14 (1), pp. 20824. Date of Electronic Publication: 2024 Sep 06.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Exploring the value of multiple preprocessors and classifiers in constructing models for predicting microsatellite instability status in colorectal cancer.

• Authors : Ma Y; Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, Nanjing, 210008, Jiangsu Province, China.; Shi Z

Subjects: Microsatellite Instability* ; Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/genetics ; Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/pathology

• Source: Scientific reports [Sci Rep] 2024 Sep 01; Vol. 14 (1), pp. 20305. Date of Electronic Publication: 2024 Sep 01.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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A prediction model based on deep learning and radiomics features of DWI for the assessment of microsatellite instability in endometrial cancer.

• Authors : Wang J; Department of Nuclear Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.; Song P

Subjects: Deep Learning* ; Diffusion Magnetic Resonance Imaging*/Diffusion Magnetic Resonance Imaging*/Diffusion Magnetic Resonance Imaging*/methods ; Endometrial Neoplasms*/Endometrial Neoplasms*/Endometrial Neoplasms*/genetics

• Source: Cancer medicine [Cancer Med] 2024 Aug; Vol. 13 (16), pp. e70046.Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 101595310 Publication Model: Print Cited Medium: Internet ISSN:

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Study of HRO761 Alone or in Combination in Cancer Patients With Specific DNA Alterations Called Microsatellite Instability or Mismatch Repair Deficiency.

• Source: An Open-label, Multi-center Phase I/Ib Dose Finding and Expansion Study of HRO761 as Single Agent and in Combinations in Patients With Microsatellite

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A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC) (CheckMate 8HW)

• Authors : Ono Pharmaceutical Co. Ltd

• Source: A Phase 3 Randomized Clinical Trial of Nivolumab Alone, Nivolumab in Combination With Ipilimumab, or Investigator's Choice Chemotherapy in Participants With

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Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008)

• Source: A Phase 2, Multicenter, Multi Arm, Study to Evaluate MK-1308A (Co-formulated Quavonlimab (MK-1308)/Pembrolizumab) Versus Other Treatments in Participants With

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A Study of Adjuvant Atezolizumab or Atezolizumab Plus Tiragolumab in Solid Tumors With Resectable Disease With Intermediate-High Risk of Recurrence and High Tumor Mutational Burden (TMB-H) or Microsatellite Instability (MSI-H) (IMperator)

• Source: A Phase II, Open Label, Randomized, Non-Comparative Cohorts Study of Adjuvant Atezolizumab or Atezolizumab Plus Tiragolumab in Solid Tumors With Resectable Disease With Intermediate-High Risk of

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Prognostic significance of negative lymph node count in microsatellite instability-high colorectal cancer.

• Authors : Dai X; Department of Colorectal and Anal Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Dai Z

Subjects: Microsatellite Instability* ; Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/pathology ; Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/genetics

• Source: World journal of surgical oncology [World J Surg Oncol] 2024 Jul 19; Vol. 22 (1), pp. 186. Date of Electronic Publication: 2024 Jul 19.Publisher: BioMed Central Country of Publication: England NLM ID: 101170544 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-7819

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Investigation of ENO2 as a promising novel marker for the progression of colorectal cancer with microsatellite instability-high.

• Authors : Cai J; School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325000, China.; The Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, 325035, China.

Subjects: Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/genetics ; Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/pathology ; Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/mortality

• Source: BMC cancer [BMC Cancer] 2024 May 09; Vol. 24 (1), pp. 573. Date of Electronic Publication: 2024 May 09.Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407

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