نتائج البحث

Idebenone vs. rAAV2-ND4 gene therapy in the treatment of Leber's hereditary optic neuropathy: An indirect comparison meta-analysis.

• Authors : Hassan, Amr K¹ (AUTHOR) ; Abu Serhan, Hashem² (AUTHOR)

• Source: Indian Journal of Ophthalmology. May2025, Vol. 73 Issue 5, p656-664. 9p.

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A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)

• Authors : National Center for Advancing Translational Sciences (NCATS); Children's National Research Institute

• Source: Investigational Study of Glycerol Tributyrate in MELAS and LHON-Plus

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DNAJC30 Mutation in a Patient with Coexisting Leber’s Hereditary Optic Neuropathy and Multiple Sclerosis (Harding’s Syndrome): A Case Report.

• Authors : KamaliZonouzi, Sara¹ (AUTHOR); Micieli, Jonathan^2,3,4 (AUTHOR)

• Source: Case Reports in Ophthalmology. Mar2025, Vol. 16 Issue 1, p246-253. 8p. 3 Illustrations.

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Safety Study of an Adeno-associated Virus Vector for Gene Therapy of Leber's Hereditary Optic Neuropathy (LHON)

• Authors : National Eye Institute (NEI); Byron Lam, Greene Professor of Ophthalmology

• Source: An Open-label Dose Escalation Study of an Adeno-associated Virus Vector (scAAV2-P1ND4v2) for Gene Therapy of Leber's Hereditary

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Leber's hereditary optic neuropathy – current status of idebenone and gene replacement therapies.

• Authors : Klopstock FEAN, Thomas¹ (AUTHOR) ; Zeng, Leopold H.¹ (AUTHOR) ; Priglinger FEBO, Claudia² (AUTHOR)

• Source: Medizinische Genetik. Apr2025, Vol. 37 Issue 1, p57-63. 7p.

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Mitochondrial tRNAGlu 14693A > G Mutation, an "Enhancer" to the Phenotypic Expression of Leber's Hereditary Optic Neuropathy.

• Authors : Jin, Lihao^1,2,3 (AUTHOR); Gan, Dingyi^1,2,3 (AUTHOR); He, Wentao^1,2,3 (AUTHOR)

• Source: Advanced Science. 11/6/2024, Vol. 11 Issue 41, p1-14. 14p.

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Efficacy of Intravitreal rAAV2-ND4 Injection in Treated Versus Fellow Eyes with Leber's Hereditary Optic Neuropathy: A Meta-Analysis.

• Authors : Hassan, Amr K.¹ (AUTHOR); Mohsen, Maram² (AUTHOR); Abu Serhan, Hashem³ (AUTHOR)

• Source: Neuro-Ophthalmology. Oct-Dec2024, Vol. 48 Issue 6, p391-400. 10p.

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Diagnostic dilemma: Leber's hereditary optic neuropathy in a 70-year-Old woman

• Authors : Alexandra Pietraszkiewicz; Azraa Ayesha; Kathleen B. Digre

Subjects: Leber's hereditary optic neuropathy; Mitochondrial disease; Optic neuropathy

• Source: American Journal of Ophthalmology Case Reports, Vol 36, Iss , Pp 102143- (2024)

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Leber’s hereditary optic neuropathy and multiple sclerosis: overlap between mitochondrial disease and neuroinflammation

• Authors : Golbarg Rahimi; Mackenzie Silverman; Maeve Lucas

Subjects: mitochondrial dysfunction; Leber’s hereditary optic neuropathy; multiple sclerosis

• Source: Frontiers in Neurology, Vol 16 (2025)

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Gene Therapy Clinical Trial for the Treatment of Leber's Hereditary Optic Neuropathy Associated With ND1 Mutations

• Source: A Phase 1/2, Multi-regional, Single-Arm, Open-Label, Dose-Finding Clinical Trial to Evaluate the Safety, Tolerability and Efficacy of Gene Therapy for Leber's

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