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HSP90 deficiency promotes cholesteryl ester accumulation in lipid droplets via endocytosis of low-density lipoprotein.

• Authors : Ma C; Shanghai Key Laboratory of Metabolic Remodeling and Health, State Key Laboratory of Genetics and Development of Complex Phenotypes, Institute of Metabolism and Integrative Biology, School of Life Sciences, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.; Che X

Subjects: Cholesterol Esters*/Cholesterol Esters*/Cholesterol Esters*/metabolism ; Endocytosis* ; HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/genetics

• Source: Communications biology [Commun Biol] 2025 Aug 06; Vol. 8 (1), pp. 1169. Date of Electronic Publication: 2025 Aug 06.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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HER2-Driven Breast Cancer: Role of the Chaperonin HSP90 in Modulating Response to Trastuzumab-Based Therapeutic Combinations.

• Authors : Falcone I; SAFU, Department of Research, Advanced Diagnostics, and Technological Innovation, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, Italy.; Giontella E

Subjects: HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/metabolism ; HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/genetics ; Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/drug therapy

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 Jul 09; Vol. 26 (14). Date of Electronic Publication: 2025 Jul 09.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Cisplatin palbociclib combination differentially modulates PTEN AKT signaling via Hsp90 in hepatocellular carcinoma cells.

• Authors : Sleem HM; Department of Pharmacology and Biochemistry, Faculty of Pharmacy, The British University in Egypt, El Sherouk City, Egypt. .; Drug Research and Development Group (DRD), Health Research Center of Excellence, The British University in Egypt, El Sherouk City, Egypt. .

Subjects: Cisplatin*/Cisplatin*/Cisplatin*/pharmacology ; Piperazines*/Piperazines*/Piperazines*/pharmacology ; Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/metabolism

• Source: Scientific reports [Sci Rep] 2025 Jun 02; Vol. 15 (1), pp. 19319. Date of Electronic Publication: 2025 Jun 02.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Benzbromarone interferes with the interaction between Hsp90 and Aha1 by interacting with both of them.

• Authors : Zhong Y; State Key Laboratory of Chemical Biology, Analytical Research Center for Organic and Biological Molecules, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of the Chinese Academy of Sciences, Beijing, China.

Subjects: HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/metabolism ; HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/chemistry ; Benzbromarone*/Benzbromarone*/Benzbromarone*/pharmacology

• Source: Communications biology [Commun Biol] 2025 May 16; Vol. 8 (1), pp. 761. Date of Electronic Publication: 2025 May 16.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Effects of Thermal Manipulation and Serotonin Modulation on Brain HSP70 and HSP90 Gene Expression in Late Embryogenesis of Broilers.

• Authors : KHasti H; Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.; Emadi L

Subjects: Serotonin*/Serotonin*/Serotonin*/metabolism ; Serotonin*/Serotonin*/Serotonin*/pharmacology ; HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/metabolism

• Source: Veterinary medicine and science [Vet Med Sci] 2025 May; Vol. 11 (3), pp. e70195.Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 101678837 Publication Model: Print Cited Medium: Internet ISSN:

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基于Hsp90的荧光分子探针的构建与胰腺肿瘤识别效应评价.

• Authors : 罗浩君¹; 孔德欣¹; 黄薇¹

• Source: Basic & Clinical Medicine. Jul2025, Vol. 45 Issue 7, p905-911. 7p.

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EP4 receptor agonist CAY10598 upregulates ROS-dependent Hsp90 cleavage in colorectal cancer cells

• Authors : In Gyung, Chae; Joohee, Jung; Do-Hee, Kim

Subjects: Mice; Humans; Animals

• Source: Free Radical Research. 58:596-605

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HSP90 co-regulates the formation and nuclear distribution of the glycolytic output complex to promote resistance and poor prognosis in gastric cancer patients.

• Authors : Shen G; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.; Liu S

Subjects: HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/metabolism ; Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/metabolism ; Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/pathology

• Source: Journal of translational medicine [J Transl Med] 2025 Feb 10; Vol. 23 (1), pp. 172. Date of Electronic Publication: 2025 Feb 10.Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876

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[11C]HSP990 PET as a translational tool to investigate the role of Hsp90 in tumours and support the development of Hsp90 therapeutics.

• Authors : Cools, Romy¹ (AUTHOR); Narykina, Valeria^1,2,3 (AUTHOR); Vermeulen, Koen⁴ (AUTHOR)

• Source: EJNMMI Radiopharmacy & Chemistry. 9/26/2025, Vol. 10 Issue 1, p1-25. 25p.

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Combination Strategies with HSP90 Inhibitors in Cancer Therapy: Mechanisms, Challenges, and Future Perspectives.

• Authors : Kim, Yeongbeom¹ (AUTHOR); Lim, Su Yeon^1,2 (AUTHOR); Kim, Hyun-Ouk^1,2,3 (AUTHOR)

• Source: Pharmaceuticals (14248247). Aug2025, Vol. 18 Issue 8, p1083. 26p.

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