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Structural and Computational Analysis of Pseudomonas aeruginosa DNA Gyrase Reveals Molecular Characteristics That May Contribute to Ciprofloxacin Resistance.

• Authors : Perera L; Genomic Integrity & Structural Biology Laboratory, NIEHS, Durham, NC 27709, USA.; García-Villada L

Subjects: Pseudomonas aeruginosa*/Pseudomonas aeruginosa*/Pseudomonas aeruginosa*/enzymology ; Pseudomonas aeruginosa*/Pseudomonas aeruginosa*/Pseudomonas aeruginosa*/drug effects ; Pseudomonas aeruginosa*/Pseudomonas aeruginosa*/Pseudomonas aeruginosa*/genetics

• Source: Biomolecules [Biomolecules] 2026 Feb 18; Vol. 16 (2). Date of Electronic Publication: 2026 Feb 18.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X

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Design, synthesis, and antimicrobial evaluation of new triazole-tethered tetrazole hybrids via DNA gyrase inhibition.

• Authors : Agarwal A; Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India. .; Singh V

Subjects: Triazoles*/Triazoles*/Triazoles*/chemistry ; Triazoles*/Triazoles*/Triazoles*/pharmacology ; Topoisomerase II Inhibitors*/Topoisomerase II Inhibitors*/Topoisomerase II Inhibitors*/pharmacology

• Source: Scientific reports [Sci Rep] 2025 Oct 06; Vol. 15 (1), pp. 34695. Date of Electronic Publication: 2025 Oct 06.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

• Authors : Cotman, A. E.; Glinghammar, Björn; Kikelj, D.

Subjects: antiinfective agent; benzothiazole derivative; DNA topoisomerase (ATP hydrolysing)

• Source: Journal of Medicinal Chemistry. 66(2):1380-1425

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Bioactive Compounds from Trentepohlia aurea as Potential Antibacterial Agents Targeting DNA Gyrase: An In Vitro and In Silico Approach.

• Authors : Atni, Oky Kusuma¹; Munir, Erman¹ ; Pasaribu, Nursahara¹

• Source: Trends in Sciences. Jan2026, Vol. 23 Issue 1, p1-22. 22p.

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Design, synthesis, and antimicrobial evaluation of novel quinazoline piperazine phosphorodiamidate hybrids as potent DNA gyrase inhibitors.

• Authors : Donka SB; Department of Chemistry, Sri Venkateswara University, Tirupati, 517502, Andhra Pradesh, India.; Kethineni S

Subjects: Topoisomerase II Inhibitors*/Topoisomerase II Inhibitors*/Topoisomerase II Inhibitors*/pharmacology ; Topoisomerase II Inhibitors*/Topoisomerase II Inhibitors*/Topoisomerase II Inhibitors*/chemical synthesis ; Topoisomerase II Inhibitors*/Topoisomerase II Inhibitors*/Topoisomerase II Inhibitors*/chemistry

• Source: Scientific reports [Sci Rep] 2025 Sep 30; Vol. 15 (1), pp. 33964. Date of Electronic Publication: 2025 Sep 30.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Synthesis, Photophysical Properties, Antibacterial Activity, DNA Gyrase Inhibition, and Molecular Docking Studies of New Thiophene–Furan Push–Pull Fluorophores.

• Authors : Al nami, Samar Y.¹ (AUTHOR); Hossan, Aisha¹ (AUTHOR)

• Source: Arabian Journal for Science & Engineering (Springer Science & Business Media B.V. ). Jan2026, Vol. 51 Issue 2, p1485-1496. 12p.

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Molecular modeling and optimization of pyranoquinolinone derivatives as potential DNA gyrase inhibitors for typhoid fever treatment: A Comprehensive QSAR, molecular docking, ADMET, and molecular dynamics simulation studies

• Authors : Philip John Ameji; Adamu Uzairu; Gideon Adamu Shallangwa

Subjects: QSAR; DNA gyrase; Salmonella typhi

• Source: In Silico Research in Biomedicine, Vol 2, Iss , Pp 100166- (2026)

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Structural basis of DNA crossover capture by Escherichia coli DNA gyrase

• Authors : Vayssières, Marlène; Marechal, Nils; Yun, Long ...

Subjects: Medical Sciences; [SDV.BBM.BS] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM]; DNA, Superhelical

• Source: Science. 384:227-232

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Phytochemical profiling of Vitex negundo seeds via UHPLC-QTOF-MS/MS analyses with antimicrobial evaluation and in silico targeting of DNA Gyrase B and Secreted Aspartic Proteinase 2 (SAP2).

• Authors : Mustafa, Javed¹ (AUTHOR); Ashraf, Tuba¹ (AUTHOR); Ali, Basharat¹ (AUTHOR)

• Source: PLoS ONE. 3/13/2026, Vol. 21 Issue 3, p1-25. 25p.

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In silico analysis of luteolin derivatives as antibacterial agents targeting DNA gyrase and CTX-M-15 extended-spectrum β-lactamase of Escherichia coli

• Authors : Nuzul Wahyuning Diyah; Dwi Ayu Indriani; Rachma Dessidianti

Subjects: extended-spectrum β-lactamase ctx-m-15; 0301 basic medicine; 0303 health sciences

• Source: J Adv Pharm Technol ResJournal of Advanced Pharmaceutical Technology & Research, Vol 15, Iss 1, Pp 29-36 (2024)

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