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Click Chemistry: Approaches, Applications and Challenges

• Authors : Zong-Rui Tong

Subjects: Chemical equilibrium; Chemical reactions; BiocompatibilitySCIENCE / Chemistry / General

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Synthesis of Comb-like and Coil-Comb Polystyrene–Polyglycidol Copolymers via Click Chemistry: Self-Assembly and Biological Evaluation.

• Authors : Toncheva-Moncheva, Natalia^1,2 (AUTHOR) ; Dimitrov, Erik^1,2 (AUTHOR); Delcheva, Niya^1,3 (AUTHOR)

• Source: Polymers (20734360). Feb2026, Vol. 18 Issue 4, p517. 25p.

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Nanostructured Lipid Carriers Overcome the Low Immunogenicity of M2e Peptide via Surface Click Chemistry Conjugation, Improving the Anti‐M2e Antibody Response.

• Authors : Bourlon, Louis^1,2,3 (AUTHOR); Fournier, Carole¹ (AUTHOR); Hoang, Antoine² (AUTHOR)

• Source: Advanced Nanobiomed Research. Feb2026, p1. 11p. 6 Illustrations.

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Click Chemistry-Enabled Parallel Synthesis of N -Acyl Sulfonamides and Their Evaluation as Carbonic Anhydrase Inhibitors.

• Authors : Gavrylenko, Oleksii V.^1,2 (AUTHOR); Vashchenko, Bohdan V.^2,3,4 (AUTHOR); Naumchyk, Vasyl^1,3 (AUTHOR)

• Source: Molecules. Jan2026, Vol. 31 Issue 2, p318. 11p.

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Advancing Bioconjugated Quantum Dots with Click Chemistry and Artificial Intelligence to Image and Treat Glioblastoma.

• Authors : Kalaga P; Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, 6439 Garners Ferry Road, Columbia, SC 29209, USA.; Ray SK

Subjects: Quantum Dots*/Quantum Dots*/Quantum Dots*/chemistry ; Quantum Dots*/Quantum Dots*/Quantum Dots*/therapeutic use ; Glioblastoma*/Glioblastoma*/Glioblastoma*/diagnostic imaging

• Source: Cells [Cells] 2026 Jan 19; Vol. 15 (2). Date of Electronic Publication: 2026 Jan 19.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Modular Virus-like Particles for Antigen Presentation: Comparing Genetic Fusion and Click-Chemistry for Purification.

• Authors : Balbierer K; ARTES Biotechnology GmbH, 40764 Langenfeld, Germany.; Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, 48149 Münster, Germany.

Subjects: Click Chemistry*/Click Chemistry*/Click Chemistry*/methods ; Vaccines, Virus-Like Particle*/Vaccines, Virus-Like Particle*/Vaccines, Virus-Like Particle*/immunology ; Vaccines, Virus-Like Particle*/Vaccines, Virus-Like Particle*/Vaccines, Virus-Like Particle*/genetics

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 15; Vol. 26 (20). Date of Electronic Publication: 2025 Oct 15.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Thiol-Epoxy Click Chemistry: The Synthesis of Vicinal Amino Alcohols Containing a 1,2,4-Triazole Ring.

• Authors : Petrosyan, Artyom V.¹ (AUTHOR); Shahkhatuni, Astghik A.² (AUTHOR); Davinyan, Andranik M.^2,3 (AUTHOR)

• Source: Chemistry (2624-8549). Apr2025, Vol. 7 Issue 2, p53. 19p.

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Triazole-based click chemistry as strategic for novel therapeutics treatments of cancer: A bibliometric analysis 2007-2024.

• Authors : Cardona-Galeano, Wilson¹ ; Yepes, Andres F.¹; Ramírez-Malule, Howard²

• Source: Journal of Applied Pharmaceutical Science. May2025, Vol. 15 Issue 5, p064-074. 11p.

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Discovery of Boronic Acids-Based β-Lactamase Inhibitors Through In Situ Click Chemistry.

• Authors : Santi, Nicolò¹ (AUTHOR); Piccirilli, Alessandra² (AUTHOR); Corsini, Federico^1,3 (AUTHOR)

• Source: International Journal of Molecular Sciences. May2025, Vol. 26 Issue 9, p4182. 21p.

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Design and in vitro anticancer assessment of a click chemistry-derived dinuclear copper artificial metallo-nuclease

• Authors : Poole, Simon; Aning, Obed Akwasi, 1987; McKee, Vickie

• Source: Nucleic Acids Research AFM data for: Development and In Vitro Anticancer Evaluation of a Click Chemistry Derived Dinuclear Copper

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