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Academic Journal

PDE3A as a Therapeutic Target for the Modulation of Compartmentalised Cyclic Nucleotide-Dependent Signalling.

Authors : Pati SR; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.; Faculty of Biology, Chemistry, Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany.

Subjects: Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/Cyclic Nucleotide Phosphodiesterases, Type 3*/metabolism ; Signal Transduction* ; Cyclic AMP*/Cyclic AMP*/Cyclic AMP*/metabolism

Source: Cells [Cells] 2025 May 23; Vol. 14 (11). Date of Electronic Publication: 2025 May 23.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Academic Journal

Plasma levels of soluble PD-1, TIM-3, LAG-3 and galectin-3 and the degree of liver fibrosis in CHC and the impact of successful antiviral treatment on their levels.

Authors : Osuch S; Department of Immunopathology of Infectious and Parasitic Diseases, Medical University of Warsaw, 3c Pawińskiego Street, Warsaw, 02-106, Poland.; Kumorek A

Subjects: Hepatitis A Virus Cellular Receptor 2*/Hepatitis A Virus Cellular Receptor 2*/Hepatitis A Virus Cellular Receptor 2*/blood ; Liver Cirrhosis*/Liver Cirrhosis*/Liver Cirrhosis*/blood ; Liver Cirrhosis*/Liver Cirrhosis*/Liver Cirrhosis*/drug therapy

Source: Scientific reports [Sci Rep] 2025 May 02; Vol. 15 (1), pp. 15436. Date of Electronic Publication: 2025 May 02.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Identification of AS1842856 as a novel small-molecule GSK3α/β inhibitor against Tauopathy by accelerating GSK3α/β exocytosis.

Authors : He DL; Key Laboratory of Medical Cell Biology of Ministry of Education, Key Laboratory of Major Chronic Diseases of Nervous System of Liaoning Province, Health Sciences Institute of China Medical University, Shenyang, China.; Zhang XY

Subjects: Tauopathies*/Tauopathies*/Tauopathies*/drug therapy ; Tauopathies*/Tauopathies*/Tauopathies*/metabolism ; Exocytosis*/Exocytosis*/Exocytosis*/drug effects

Source: Aging cell [Aging Cell] 2025 Jan; Vol. 24 (1), pp. e14336. Date of Electronic Publication: 2024 Sep 17.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Analysis of the Clinical Value of Galectin-3 and Heart-Type Fatty Acid-Binding Protein Levels in the Diagnosis and Prognosis of Viral Myocarditis in Children.

Authors : Cui X; Department of Pediatrics, The Affiliated Hospital of Qingdao University.; Department of Pediatrics, The Affiliated Hospital of Jining Medical University.

Subjects: Myocarditis*/Myocarditis*/Myocarditis*/blood ; Myocarditis*/Myocarditis*/Myocarditis*/virology ; Myocarditis*/Myocarditis*/Myocarditis*/diagnosis

Source: International heart journal [Int Heart J] 2025; Vol. 66 (4), pp. 570-576.Publisher: International Heart Journal Association Country of Publication: Japan NLM ID: 101244240 Publication Model: Print Cited Medium: Internet

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Academic Journal

Adropin/Tirzepatide Combination Mitigates Cardiac Metabolic Aberrations in a Rat Model of Polycystic Ovarian Syndrome, Implicating the Role of the AKT/GSK3β/NF-κB/NLRP3 Pathway.

Authors : Hegab II; Physiology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.; Bio-Physiology Department, Ibn Sina National College for Medical Studies, Jeddah 21442, Saudi Arabia.

Subjects: Polycystic Ovary Syndrome*/Polycystic Ovary Syndrome*/Polycystic Ovary Syndrome*/metabolism ; Polycystic Ovary Syndrome*/Polycystic Ovary Syndrome*/Polycystic Ovary Syndrome*/drug therapy ; NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism

Source: International journal of molecular sciences [Int J Mol Sci] 2024 Dec 24; Vol. 26 (1). Date of Electronic Publication: 2024 Dec 24.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Myeloid GSK3α Deficiency Reduces Lesional Inflammation and Neovascularization during Atherosclerotic Progression.

Authors : Patel S; The Thrombosis and Atherosclerosis Research Institute, Hamilton, ON L8L 2X2, Canada.; Shah N

Subjects: Atherosclerosis*/Atherosclerosis*/Atherosclerosis*/pathology ; Atherosclerosis*/Atherosclerosis*/Atherosclerosis*/metabolism ; Atherosclerosis*/Atherosclerosis*/Atherosclerosis*/genetics

Source: International journal of molecular sciences [Int J Mol Sci] 2024 Oct 10; Vol. 25 (20). Date of Electronic Publication: 2024 Oct 10.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

DVL/GSK3/ISL1 pathway signaling: unraveling the mechanism of SIRT3 in neurogenesis and AD therapy.

Authors : Dai N; Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, Guangdong, China.; Su X

Subjects: Neurogenesis* ; Sirtuin 3*/Sirtuin 3*/Sirtuin 3*/metabolism ; Sirtuin 3*/Sirtuin 3*/Sirtuin 3*/genetics

Source: Stem cell research & therapy [Stem Cell Res Ther] 2024 Sep 12; Vol. 15 (1), pp. 299. Date of Electronic Publication: 2024 Sep 12.Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512

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Academic Journal

Ligustrazine alleviates the progression of coronary artery calcification by inhibiting caspase-3/GSDME mediated pyroptosis.

Authors : Yang H; Department of Cardiology, Zhengzhou University, Central China Fuwai Hospital, Zhengzhou, China.; Xu G

Subjects: Pyroptosis*/Pyroptosis*/Pyroptosis*/drug effects ; Pyrazines*/Pyrazines*/Pyrazines*/pharmacology ; Pyrazines*/Pyrazines*/Pyrazines*/therapeutic use

Source: Bioscience trends [Biosci Trends] 2024 Nov 15; Vol. 18 (5), pp. 482-491. Date of Electronic Publication: 2024 Jul 06.Publisher: International Research and Cooperation Association for Bio & Socio-Sciences Advancement Country of Publication: Japan NLM ID: 101502754 Publication

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Academic Journal

β-Ionone enhances the inhibitory effects of 5-fluorouracil on the proliferation of gastric adenocarcinoma cells by the GSK-3β signaling pathway.

Authors : Wang FL; Department of Clinical Laboratory, The Forth Affiliated Hospital of Harbin Medical University, Nangang District, Harbin, China.; Chang X

Subjects: Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/drug therapy ; Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/pathology ; Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/metabolism

Source: PloS one [PLoS One] 2024 Sep 06; Vol. 19 (9), pp. e0309014. Date of Electronic Publication: 2024 Sep 06 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Theoretical Investigations on Free Energy of Binding Cilostazol with Different Cyclodextrins as Complex for Selective PDE3 Inhibition.

Authors : Hoelm M; Department of Physical Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 163/165, 90-236 Lodz, Poland.; Chowdhury N

Subjects: Cilostazol*/Cilostazol*/Cilostazol*/chemistry ; Phosphodiesterase 3 Inhibitors*/Phosphodiesterase 3 Inhibitors*/Phosphodiesterase 3 Inhibitors*/chemistry ; Phosphodiesterase 3 Inhibitors*/Phosphodiesterase 3 Inhibitors*/Phosphodiesterase 3 Inhibitors*/pharmacology

Source: Molecules (Basel, Switzerland) [Molecules] 2024 Aug 12; Vol. 29 (16). Date of Electronic Publication: 2024 Aug 12.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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فلترة النتائج

PDE3A as a Therapeutic Target for the Modulation of Compartmentalised Cyclic Nucleotide-Dependent Signalling.

Plasma levels of soluble PD-1, TIM-3, LAG-3 and galectin-3 and the degree of liver fibrosis in CHC and the impact of successful antiviral treatment on their levels.

Identification of AS1842856 as a novel small-molecule GSK3α/β inhibitor against Tauopathy by accelerating GSK3α/β exocytosis.

Analysis of the Clinical Value of Galectin-3 and Heart-Type Fatty Acid-Binding Protein Levels in the Diagnosis and Prognosis of Viral Myocarditis in Children.

Adropin/Tirzepatide Combination Mitigates Cardiac Metabolic Aberrations in a Rat Model of Polycystic Ovarian Syndrome, Implicating the Role of the AKT/GSK3β/NF-κB/NLRP3 Pathway.

Myeloid GSK3α Deficiency Reduces Lesional Inflammation and Neovascularization during Atherosclerotic Progression.

DVL/GSK3/ISL1 pathway signaling: unraveling the mechanism of SIRT3 in neurogenesis and AD therapy.

Ligustrazine alleviates the progression of coronary artery calcification by inhibiting caspase-3/GSDME mediated pyroptosis.

β-Ionone enhances the inhibitory effects of 5-fluorouracil on the proliferation of gastric adenocarcinoma cells by the GSK-3β signaling pathway.

Theoretical Investigations on Free Energy of Binding Cilostazol with Different Cyclodextrins as Complex for Selective PDE3 Inhibition.

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