نتائج البحث

Folding and Intrinsic Disorder of the Receptor Tyrosine Kinase KIT Insert Domain Seen by Conventional Molecular Dynamics Simulations.

• Authors : Ledoux J; Centre Borelli, CNRS, ENS Paris-Saclay, Université Paris-Saclay, 4 Avenue des Sciences, F-91190 Gif-sur-Yvette, France.; Trouvé A

Subjects: Molecular Dynamics Simulation*; Amino Acid Sequence/Amino Acid Sequence/Amino Acid Sequence/*genetics ; Receptor Protein-Tyrosine Kinases/Receptor Protein-Tyrosine Kinases/Receptor Protein-Tyrosine Kinases/*chemistry

• Source: International journal of molecular sciences [Int J Mol Sci] 2021 Jul 09; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 09.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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High resolution crystal structure of the FAK FERM domain reveals new insights on the Druggability of tyrosine 397 and the Src SH3 binding site.

• Authors : Marlowe T; Interdisciplinary Oncology, University of Arizona College of Medicine - Phoenix, 475 N 5th Street, Phoenix, AZ, 85004, USA. .; Pharmacology and Toxicology, University of Arizona College of Pharmacy, P.O. Box 210207, Tucson, AZ, 85721, USA. .

Subjects: Crystallization* ; FERM Domains* ; src Homology Domains*

• Source: BMC molecular and cell biology [BMC Mol Cell Biol] 2019 May 20; Vol. 20 (1), pp. 10. Date of Electronic Publication: 2019 May 20.Publisher: BioMed Central Country of Publication: England NLM ID: 101741148 Publication Model: Electronic Cited Medium: Internet ISSN: 2661-8850

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Innovative Approaches in Cancer Treatment: Emphasizing the Role of Nanomaterials in Tyrosine Kinase Inhibition.

• Authors : Kurillová, Antónia¹ (AUTHOR); Kvítek, Libor¹ (AUTHOR); Panáček, Aleš¹ (AUTHOR)

• Source: Pharmaceutics. Jun2025, Vol. 17 Issue 6, p783. 42p.

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Importance of tyrosine phosphorylation for transmembrane signaling in plants.

• Authors : Mühlenbeck H; Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, 8008 Zurich, Switzerland.; Bender KW

Subjects: Protein Processing, Post-Translational* ; Signal Transduction*; Cell Membrane/Cell Membrane/Cell Membrane/*metabolism

• Source: The Biochemical journal [Biochem J] 2021 Jul 30; Vol. 478 (14), pp. 2759-2774.Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited

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Mechanism of dual specificity kinase activity of DYRK1A.

• Authors : Walte A; Institute of Pharmacology and Toxicology, RWTH Aachen University, Germany.; Rüben K

Subjects: Protein Processing, Post-Translational*; Protein Serine-Threonine Kinases/Protein Serine-Threonine Kinases/Protein Serine-Threonine Kinases/*metabolism ; Protein-Tyrosine Kinases/Protein-Tyrosine Kinases/Protein-Tyrosine Kinases/*metabolism

• Source: The FEBS journal [FEBS J] 2013 Sep; Vol. 280 (18), pp. 4495-511. Date of Electronic Publication: 2013 Jul 22.Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication

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Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors.

• Authors : Mitra SK; Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Mikolon D

Subjects: Focal Adhesion Protein-Tyrosine Kinases/Focal Adhesion Protein-Tyrosine Kinases/Focal Adhesion Protein-Tyrosine Kinases/*metabolism ; Mammary Neoplasms, Animal/Mammary Neoplasms, Animal/Mammary Neoplasms, Animal/*enzymology ; Neovascularization, Pathologic/Neovascularization, Pathologic/Neovascularization, Pathologic/*enzymology

• Source: Oncogene [Oncogene] 2006 Sep 28; Vol. 25 (44), pp. 5969-84. Date of Electronic Publication: 2006 May 08.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Print ISSN:

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Membrane depolarization-induced RhoA/Rho-associated kinase activation and sustained contraction of rat caudal arterial smooth muscle involves genistein-sensitive tyrosine phosphorylation.

• Authors : Mita M; Tanaka H; Yanagihara H

Subjects: Arteries/Arteries/Arteries/*drug effects ; Genistein/Genistein/Genistein/*pharmacology ; Membrane Potentials/Membrane Potentials/Membrane Potentials/*physiology

• Source: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi [J Smooth Muscle Res] 2013; Vol. 49, pp. 26-45.Publisher: Dō Gakkai Country of Publication: Japan NLM ID: 9211664 Publication Model: Print Cited Medium: Internet ISSN: 1884-8796 (Electronic)

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MERTK Inhibition as a Targeted Novel Cancer Therapy.

• Authors : Tanim, K.M.^1,2 (AUTHOR) ; Holtzhausen, Alisha³ (AUTHOR) ; Thapa, Aashis^1,2 (AUTHOR)

Subjects: *Cancer treatment; *Phosphatidylserines; *Kinases

• Source: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 14, p7660. 22p.

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Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation.

• Authors : Tsutsumi K; Department of Biological Sciences, Tokyo Metropolitan University, Hachioji, Tokyo, Japan.; Takano T

Subjects: Apoptosis Regulatory Proteins/Apoptosis Regulatory Proteins/Apoptosis Regulatory Proteins/*metabolism ; Brain/Brain/Brain/*metabolism ; Cyclin-Dependent Kinase 5/Cyclin-Dependent Kinase 5/Cyclin-Dependent Kinase 5/*metabolism

• Source: PloS one [PLoS One] 2010 Apr 20; Vol. 5 (4), pp. e10260. Date of Electronic Publication: 2010 Apr 20.Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Electronic Cited Medium: Internet

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Identification of tyrosine-phosphorylated proteins associated with metastasis and functional analysis of FER in human hepatocellular carcinoma cells.

• Authors : Li H; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China. ; Ren Z

Subjects: Neoplasm Metastasis*; Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/*metabolism ; Liver Neoplasms/Liver Neoplasms/Liver Neoplasms/*metabolism

• Source: BMC cancer [BMC Cancer] 2009 Oct 16; Vol. 9, pp. 366. Date of Electronic Publication: 2009 Oct 16.Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407

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