نتائج البحث

MELAS-Derived Neurons Functionally Improve by Mitochondrial Transfer from Highly Purified Mesenchymal Stem Cells (REC).

• Authors : Liu L; Department of Pediatrics, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo 693-8501, Japan.; Yang J

Subjects: MELAS Syndrome*/MELAS Syndrome*/MELAS Syndrome*/genetics ; MELAS Syndrome*/MELAS Syndrome*/MELAS Syndrome*/therapy ; Acidosis, Lactic*/Acidosis, Lactic*/Acidosis, Lactic*/metabolism

• Source: International journal of molecular sciences [Int J Mol Sci] 2023 Dec 06; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 06.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)

• Authors : National Center for Advancing Translational Sciences (NCATS); Children's National Research Institute

• Source: Investigational Study of Glycerol Tributyrate in MELAS and LHON-Plus

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One mutation, three phenotypes: novel metabolic insights on MELAS, MIDD and myopathy caused by the m.3243A > G mutation.

• Authors : Esterhuizen K; Mitochondria Research Laboratory, Human Metabolomics, North-West University, Potchefstroom, South Africa.; Lindeque JZ

Subjects: Mutation* ; Phenotype*; Deafness/Deafness/Deafness/*genetics Noninsulin-dependent diabetes mellitus with deafness

• Source: Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2021 Jan 12; Vol. 17 (1), pp. 10. Date of Electronic Publication: 2021 Jan 12.Publisher: Springer Country of Publication: United States NLM ID: 101274889 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-3890

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Endocrine manifestations and long-term outcomes of patients with mitochondrial diseases.

• Authors : Kim JH; Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.; Kim D

Subjects: Mitochondrial Diseases*/Mitochondrial Diseases*/Mitochondrial Diseases*/pathology ; Mitochondrial Diseases*/Mitochondrial Diseases*/Mitochondrial Diseases*/physiopathology ; Endocrine System Diseases*

• Source: Orphanet journal of rare diseases [Orphanet J Rare Dis] 2025 May 17; Vol. 20 (1), pp. 235. Date of Electronic Publication: 2025 May 17.Publisher: BioMed Central Country of Publication: England NLM ID: 101266602 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1172

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Phase 2a Study of IW-6463 in Adults Diagnosed With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS)

• Source: A Phase 2a Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Individuals With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (

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Primary mitochondrial diseases: The intertwined pathophysiology of bioenergetic dysregulation, oxidative stress and neuroinflammation.

• Authors : Aguilar K; Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain.; Jakubek P

Subjects: Oxidative Stress*/Oxidative Stress*/Oxidative Stress*/physiology ; Mitochondrial Diseases*/Mitochondrial Diseases*/Mitochondrial Diseases*/physiopathology ; Mitochondrial Diseases*/Mitochondrial Diseases*/Mitochondrial Diseases*/metabolism

• Source: European journal of clinical investigation [Eur J Clin Invest] 2024 Jul; Vol. 54 (7), pp. e14217. Date of Electronic Publication: 2024 Apr 21.Publisher: Wiley Country of Publication: England NLM ID: 0245331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2362

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Lifestyle Changes Normalize Serum Lactate Levels in an m.3243A>G Carrier.

• Authors : Finsterer J; Neurological Department, Landstrasse Clinic, Messerli Institute, Vienna, Austria.

Subjects: Life Style*; DNA, Mitochondrial/DNA, Mitochondrial/DNA, Mitochondrial/*genetics ; Lactates/Lactates/Lactates/*blood

• Source: The American journal of case reports [Am J Case Rep] 2021 Apr 19; Vol. 22, pp. e930175. Date of Electronic Publication: 2021 Apr 19.Publisher: International Scientific Information, Inc Country of Publication: United States NLM ID: 101489566 Publication Model: Electronic Cited Medium:

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Epilepsy and MELAS syndrome: literature review and clinical observation

• Authors : А. М. Teplysheva; М. А. Glazova; R. N. Konovalov

Subjects: mitochondrial diseases; melas syndrome; epileptic seizures

• Source: Эпилепсия и пароксизмальные состояния, Vol 15, Iss 4, Pp 361-371 (2023)

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MIDD Patients Should Not Be Confused with MELAS Patients, Even Though Both Carry the m.3243A>G Variant

• Authors : Josef Finsterer; Sounira Mehri

Subjects: Diagnosis, Differential; Letter; Mitochondrial Diseases

• Source: Diabetes Metab JDiabetes & Metabolism Journal, Vol 48, Iss 4, Pp 816-817 (2024)

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Impact of Mitochondrial A3243G Heteroplasmy on Mitochondrial Bioenergetics and Dynamics of Directly Reprogrammed MELAS Neurons.

• Authors : Lin, Dar-Shong^1,2 (AUTHOR) ; Huang, Yu-Wen³ (AUTHOR); Ho, Che-Sheng^2,4 (AUTHOR)

• Source: Cells (2073-4409). Jan2023, Vol. 12 Issue 1, p15. 20p.

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