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  • 1-10 ل  55 نتائج ل ""Progranulins""

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Subject : lysosomes
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Academic Journal

TFEB overexpression alleviates autophagy-lysosomal deficits caused by progranulin insufficiency.

  • Authors : Nader WO; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Evelyn F. McKnight Brain Institute, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.; Brown KS

Subjects: Progranulins*/Progranulins*/Progranulins*/genetics ; Progranulins*/Progranulins*/Progranulins*/deficiency ; Progranulins*/Progranulins*/Progranulins*/metabolism

  • Source: Scientific reports [Sci Rep] 2025 Jul 19; Vol. 15 (1), pp. 26217. Date of Electronic Publication: 2025 Jul 19.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

The role of endolysosomal progranulin and TMEM106B in neurodegenerative diseases.

  • Authors : Takahashi H; Cellular Neuroscience, Neurodegeneration, Repair, Departments of Neurology and of Neuroscience, Yale University School of Medicine, New Haven, CT, 06536, USA.; Strittmatter SM

Subjects: Progranulins*/Progranulins*/Progranulins*/metabolism ; Neurodegenerative Diseases*/Neurodegenerative Diseases*/Neurodegenerative Diseases*/metabolism ; Membrane Proteins*/Membrane Proteins*/Membrane Proteins*/metabolism

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2025 Jul 26; Vol. 20 (1), pp. 86. Date of Electronic Publication: 2025 Jul 26.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

Microglial progranulin differently regulates hypothalamic lysosomal function in lean and obese conditions via cleavage-dependent mechanisms.

  • Authors : Park CB; Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.; Lee CH

Subjects: Progranulins*/Progranulins*/Progranulins*/metabolism ; Lysosomes*/Lysosomes*/Lysosomes*/metabolism ; Obesity*/Obesity*/Obesity*/metabolism

  • Source: Journal of neuroinflammation [J Neuroinflammation] 2025 Mar 07; Vol. 22 (1), pp. 68. Date of Electronic Publication: 2025 Mar 07.Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094

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Academic Journal

ASO-mediated knock-down of GPNMB in mutant-GRN and in Grn-deficient peripheral myeloid cells disrupts lysosomal function and immune responses.

  • Authors : Wallings RL; Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, McKnight Brain Institute, Gainesville, FL, 32610, USA. .; Current address: Department of Neurology, School of Medicine, Stark Neurosciences Research Institute, Indiana University, Indianapolis, IN, USA. .

Subjects: Lysosomes*/Lysosomes*/Lysosomes*/metabolism ; Membrane Glycoproteins*/Membrane Glycoproteins*/Membrane Glycoproteins*/metabolism ; Membrane Glycoproteins*/Membrane Glycoproteins*/Membrane Glycoproteins*/genetics

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2025 Apr 08; Vol. 20 (1), pp. 41. Date of Electronic Publication: 2025 Apr 08.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency.

  • Authors : Frew J; Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.; Baradaran-Heravi A

Subjects: Frontotemporal Lobar Degeneration/Frontotemporal Lobar Degeneration/Frontotemporal Lobar Degeneration/*genetics ; Gene Expression/Gene Expression/Gene Expression/*drug effects ; Gentamicins/Gentamicins/Gentamicins/*pharmacology

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2020 Mar 16; Vol. 15 (1), pp. 21. Date of Electronic Publication: 2020 Mar 16.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration.

  • Authors : Mohan S; Department of Neurology, Memory and Aging Center, University of California, San Francisco, California, 94143, USA.; Sampognaro PJ

Subjects: Frontotemporal Lobar Degeneration/Frontotemporal Lobar Degeneration/Frontotemporal Lobar Degeneration/*enzymology ; Granulins/Granulins/Granulins/*metabolism ; Lysosomes/Lysosomes/Lysosomes/*enzymology

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2021 Aug 03; Vol. 16 (1), pp. 51. Date of Electronic Publication: 2021 Aug 03.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

Progranulin deficiency in Iba-1 + myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation.

  • Authors : Takahashi K; Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, 501-1196, Japan.; Nakamura S

Subjects: Calcium-Binding Proteins* ; Microfilament Proteins*; Choroidal Neovascularization/Choroidal Neovascularization/Choroidal Neovascularization/*metabolism

  • Source: Journal of neuroinflammation [J Neuroinflammation] 2021 Jul 25; Vol. 18 (1), pp. 164. Date of Electronic Publication: 2021 Jul 25.Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094

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Academic Journal

Fibroblasts from idiopathic Parkinson's disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2.

  • Authors : Thomas R; Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, MA, 02478, USA.; Moloney EB

Subjects: Fibroblasts/Fibroblasts/Fibroblasts/*metabolism ; Glucosylceramidase/Glucosylceramidase/Glucosylceramidase/*deficiency ; Lysosomal Membrane Proteins/Lysosomal Membrane Proteins/Lysosomal Membrane Proteins/*metabolism

  • Source: Molecular brain [Mol Brain] 2021 Jan 19; Vol. 14 (1), pp. 16. Date of Electronic Publication: 2021 Jan 19.Publisher: BioMed Central Country of Publication: England NLM ID: 101468876 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-6606

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Academic Journal

Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology.

  • Authors : Mendsaikhan A; Molecular Neuroscience Research Center, Shiga University of Medical Science, Seta, Otsu, Otsu, 520-2192, Japan.; Tooyama I

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*metabolism ; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*pathology ; Lysosomes/Lysosomes/Lysosomes/*metabolism

  • Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2019 Dec 21; Vol. 7 (1), pp. 215. Date of Electronic Publication: 2019 Dec 21.Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960

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Academic Journal

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice.

  • Authors : Götzl JK; Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, 81377, Munich, Germany.; Colombo AV

Subjects: Brain/Brain/Brain/*metabolism ; Lysosomes/Lysosomes/Lysosomes/*metabolism ; Microglia/Microglia/Microglia/*metabolism

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2018 Sep 04; Vol. 13 (1), pp. 48. Date of Electronic Publication: 2018 Sep 04.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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  • 1-10 ل  55 نتائج ل ""Progranulins""