نتائج البحث

Identification and characterization of the antiplasmodial activity of Hsp90 inhibitors.

• Authors : Murillo-Solano C; Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.; Dong C

Subjects: Antimalarials/Antimalarials/Antimalarials/*pharmacology ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology ; HSP90 Heat-Shock Proteins/HSP90 Heat-Shock Proteins/HSP90 Heat-Shock Proteins/*antagonists & inhibitors

• Source: Malaria journal [Malar J] 2017 Jul 19; Vol. 16 (1), pp. 292. Date of Electronic Publication: 2017 Jul 19.Publisher: BioMed Central Country of Publication: England NLM ID: 101139802 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2875

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A repurposing strategy for Hsp90 inhibitors demonstrates their potency against filarial nematodes.

• Authors : Gillan V; Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, United Kingdom.; O'Neill K

Subjects: Brugia pahangi/Brugia pahangi/Brugia pahangi/*drug effects ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology ; Filariasis/Filariasis/Filariasis/*parasitology

• Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2014 Feb 13; Vol. 8 (2), pp. e2699. Date of Electronic Publication: 2014 Feb 13 (Print Publication: 2014).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet

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Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.

• Authors : Huth JR; Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA.; Park C

Subjects: Drug Design* ; Enzyme Inhibitors*/Enzyme Inhibitors*/Enzyme Inhibitors*/chemical synthesis ; Enzyme Inhibitors*/Enzyme Inhibitors*/Enzyme Inhibitors*/chemistry

• Source: Chemical biology & drug design [Chem Biol Drug Des] 2007 Jul; Vol. 70 (1), pp. 1-12.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262549 Publication Model: Print Cited Medium: Print ISSN: 1747-0277 (Print)

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Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: the key role of the STAT5 signal transduction pathway.

• Authors : Yao Q; The Cancer Center, University of Minnesota, Minneapolis, MN, USA.; Nishiuchi R

Subjects: DNA-Binding Proteins/DNA-Binding Proteins/DNA-Binding Proteins/*metabolism ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology ; HSP90 Heat-Shock Proteins/HSP90 Heat-Shock Proteins/HSP90 Heat-Shock Proteins/*antagonists & inhibitors

• Source: Leukemia [Leukemia] 2005 Sep; Vol. 19 (9), pp. 1605-12.Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print Cited Medium: Print

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Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.

• Authors : Azimi, Alireza¹; Caramuta, Stefano¹; Seashore‐Ludlow, Brinton²

• Source: Molecular Systems Biology. Mar2018, Vol. 14 Issue 3, p1-N.PAG. 16p.

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HSP90 inhibitors potentiate PGF2α-induced IL-6 synthesis via p38 MAP kinase in osteoblasts.

• Authors : Fujita, Kazuhiko^1,2; Tokuda, Haruhiko^2,3; Kuroyanagi, Gen^1,2

• Source: PLoS ONE. 5/19/2017, Vol. 12 Issue 5, p1-17. 17p.

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Synthesis of 5,6-dihydro-4 H-benzo[ d]isoxazol-7-one and 5,6-dihydro-4 H-isoxazolo[5,4- c]pyridin-7-one Derivatives as Potential Hsp90 Inhibitors.

• Authors : Musso, Loana¹; Cincinelli, Raffaella¹; Giannini, Giuseppe²

• Source: Chemical Biology & Drug Design. Nov2015, Vol. 86 Issue 5, p1030-1035. 6p.

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Identification, Design and Bio-Evaluation of Novel Hsp90 Inhibitors by Ligand-Based Virtual Screening.

• Authors : Jia, JianMin^1,2; Xu, XiaoLi^1,2; Liu, Fang^1,2

• Source: PLoS ONE. Apr2013, Vol. 8 Issue 4, p1-15. 15p.

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Structural Determination of Three Different Series of Compounds as Hsp90 Inhibitors Using 3D-QSAR Modeling, Molecular Docking and Molecular Dynamics Methods.

• Authors : Jianling Liu¹ ; Fangfang Wang¹ ; Zhi Ma²

• Source: International Journal of Molecular Sciences. Feb2011, Vol. 12 Issue 2, p946-970. 25p. 10 Diagrams, 1 Chart, 4 Graphs.

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HSP90 Inhibition Enhances Antimitotic Drug-Induced Mitotic Arrest and Cell Death in Preclinical Models of Non-Small Cell Lung Cancer.

• Authors : O'Connell, Brenda C.; O'Callaghan, Katie; Tillotson, Bonnie

Subjects: NON-small-cell lung carcinoma; ENZYME inhibitors; ANTIMITOTIC agents

• Source: PLoS ONE; Dec2014, Vol. 9 Issue 12, p1-20, 20p

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