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Academic Journal

Dual PDE4/10A inhibition restores CREB1 function and enhances neuronal resilience in models of alzheimer's disease.

  • Authors : Rong X; Suzhou Laboratory of Precision Health and Data Science, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215004, China. .; Institute of Health Data Science, Soochow University, Suzhou, Jiangsu, 215004, China. .

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/drug therapy ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/genetics

  • Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2025 Oct 27; Vol. 17 (1), pp. 231. Date of Electronic Publication: 2025 Oct 27.Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium:

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Academic Journal

Upregulation of GLT-1 Expression Attenuates Neuronal Apoptosis and Cognitive Dysfunction via Inhibiting the CB1-CREB Signaling Pathway in Mice with Traumatic Brain Injury.

  • Authors : Bu B; Department of Forensic Clinical Medicine, School of Forensic Medicine, China Medical University, Shenyang 110122, China.; Key Laboratory of Forensic Bio-Evidence Science, Shenyang 110122, China.

Subjects: Brain Injuries, Traumatic*/Brain Injuries, Traumatic*/Brain Injuries, Traumatic*/metabolism ; Brain Injuries, Traumatic*/Brain Injuries, Traumatic*/Brain Injuries, Traumatic*/pathology ; Brain Injuries, Traumatic*/Brain Injuries, Traumatic*/Brain Injuries, Traumatic*/genetics

  • Source: Biomolecules [Biomolecules] 2025 Oct 02; Vol. 15 (10). Date of Electronic Publication: 2025 Oct 02.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium:

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Academic Journal

miR-32533 Reduces Cognitive Impairment and Amyloid-β Overload by Targeting CREB5-Mediated Signaling Pathways in Alzheimer's Disease.

  • Authors : Zeng L; Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, P. R. China.; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, P. R. China.

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/genetics ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism ; MicroRNAs*/MicroRNAs*/MicroRNAs*/genetics

  • Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Mar; Vol. 12 (10), pp. e2409986. Date of Electronic Publication: 2025 Jan 22.Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

CaMK2A/CREB pathway activation is associated with enhanced mitophagy and neuronal apoptosis in diabetic retinopathy.

  • Authors : Yang X; The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650032, China. .; Zhang Y

Subjects: Diabetic Retinopathy*/Diabetic Retinopathy*/Diabetic Retinopathy*/metabolism ; Diabetic Retinopathy*/Diabetic Retinopathy*/Diabetic Retinopathy*/pathology ; Mitophagy*

  • Source: Scientific reports [Sci Rep] 2025 Apr 11; Vol. 15 (1), pp. 12516. Date of Electronic Publication: 2025 Apr 11.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

A Neuroprotective Peptide Modulates Retinal cAMP Response Element-Binding Protein (CREB), Synapsin I (SYN1), and Growth-Associated Protein 43 (GAP43) in Rats with Silicone Oil-Induced Ocular Hypertension.

  • Authors : Johnson GA; North Texas Eye Research Institute, College of Biomedical and Translational Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.; Department of Microbiology, Immunology, and Genetics, College of Biomedical and Translational Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

Subjects: Synapsins*/Synapsins*/Synapsins*/metabolism ; Cyclic AMP Response Element-Binding Protein*/Cyclic AMP Response Element-Binding Protein*/Cyclic AMP Response Element-Binding Protein*/metabolism ; Ocular Hypertension*/Ocular Hypertension*/Ocular Hypertension*/chemically induced

  • Source: Biomolecules [Biomolecules] 2025 Feb 03; Vol. 15 (2). Date of Electronic Publication: 2025 Feb 03.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium:

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Academic Journal

Investigation of the Roles of the Adenosine A(2A) and Metabotropic Glutamate Receptor Type 5 (mGlu5) Receptors in Prepulse Inhibition and CREB Signaling in a Heritable Rodent Model of Psychosis.

  • Authors : Cuozzo AM; Department of Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.; Peeters LD

Subjects: Receptor, Metabotropic Glutamate 5*/Receptor, Metabotropic Glutamate 5*/Receptor, Metabotropic Glutamate 5*/metabolism ; Prepulse Inhibition*/Prepulse Inhibition*/Prepulse Inhibition*/drug effects ; Receptor, Adenosine A2A*/Receptor, Adenosine A2A*/Receptor, Adenosine A2A*/metabolism

  • Source: Cells [Cells] 2025 Jan 24; Vol. 14 (3). Date of Electronic Publication: 2025 Jan 24.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium:

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Academic Journal

Nobiletin, as a Novel PDE4B Inhibitor, Alleviates Asthma Symptoms by Activating the cAMP-PKA-CREB Signaling Pathway.

  • Authors : Zhang Y; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Yang Y

Subjects: Flavones*/Flavones*/Flavones*/pharmacology ; Flavones*/Flavones*/Flavones*/chemistry ; Asthma*/Asthma*/Asthma*/drug therapy

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Sep 27; Vol. 25 (19). Date of Electronic Publication: 2024 Sep 27.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium:

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Academic Journal

TIPRL Regulates Stemness and Survival in Lung Cancer Stem Cells through CaMKK2-CaMK4-CREB Feedback Loop Activation.

  • Authors : Song IS; Department of Biochemistry and Molecular Biology, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 138-736, Republic of Korea.; Jeong YJ

Subjects: Calcium-Calmodulin-Dependent Protein Kinase Kinase*/Calcium-Calmodulin-Dependent Protein Kinase Kinase*/Calcium-Calmodulin-Dependent Protein Kinase Kinase*/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Kinase*/Calcium-Calmodulin-Dependent Protein Kinase Kinase*/Calcium-Calmodulin-Dependent Protein Kinase Kinase*/genetics ; Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/genetics

  • Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Sep; Vol. 11 (36), pp. e2406309. Date of Electronic Publication: 2024 Jul 30.Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Secoisolariciresinol diglucoside attenuates neuroinflammation and cognitive impairment in female Alzheimer's disease mice via modulating gut microbiota metabolism and GPER/CREB/BDNF pathway.

  • Authors : Jia M; College of Food Science and Engineering, Northwest A&F University, Yangling, 712100, Shaanxi, China.; Ning F

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/drug therapy ; Glucosides*/Glucosides*/Glucosides*/pharmacology

  • Source: Journal of neuroinflammation [J Neuroinflammation] 2024 Aug 12; Vol. 21 (1), pp. 201. Date of Electronic Publication: 2024 Aug 12.Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium:

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Academic Journal

Knockdown of DPP4 promotes the proliferation and the activation of the CREB/aromatase pathway in ovarian granulosa cells.

  • Authors : Lin L; Center for Reproductive Medicine, Shantou Central Hospital, Shantou, Guangdong 515041, P.R. China.; Wang L

Subjects: Aromatase/Aromatase/Aromatase/*metabolism ; Cyclic AMP Response Element-Binding Protein/Cyclic AMP Response Element-Binding Protein/Cyclic AMP Response Element-Binding Protein/*metabolism ; Dipeptidyl Peptidase 4/Dipeptidyl Peptidase 4/Dipeptidyl Peptidase 4/*genetics

  • Source: Molecular medicine reports [Mol Med Rep] 2022 Feb; Vol. 25 (2). Date of Electronic Publication: 2022 Jan 11.Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium:

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