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Afatinib amplifies cAMP-induced fluid secretion in a mouse mini-gut model via TMEM16A-mediated fluid secretion and secretory cell differentiation.

• Authors : Ariyadamrongkwan J; Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bang Phli, Samut Prakarn, Thailand.; Program in Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Subjects: Anoctamin-1*/Anoctamin-1*/Anoctamin-1*/metabolism ; Cell Differentiation*/Cell Differentiation*/Cell Differentiation*/drug effects ; Afatinib*/Afatinib*/Afatinib*/pharmacology

• Source: Scientific reports [Sci Rep] 2025 Aug 10; Vol. 15 (1), pp. 29265. Date of Electronic Publication: 2025 Aug 10.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Guilu erxian glue improves sperm quality in oligasthenospermia mice by promoting TDRP methylation and regulating the cAMP/PKA pathway.

• Authors : Zhu C; Andrology Laboratory, Hunan University of Chinese Medicine, Changsha, 410208, China.; School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China.

Subjects: Cyclic AMP*/Cyclic AMP*/Cyclic AMP*/metabolism ; Cyclic AMP-Dependent Protein Kinases*/Cyclic AMP-Dependent Protein Kinases*/Cyclic AMP-Dependent Protein Kinases*/metabolism ; Spermatozoa*/Spermatozoa*/Spermatozoa*/drug effects

• Source: Scientific reports [Sci Rep] 2025 Jul 28; Vol. 15 (1), pp. 27498. Date of Electronic Publication: 2025 Jul 28.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Electroacupuncture attenuates intervertebral disc degeneration by upregulating aquaporins via the cAMP/PKA pathway.

• Authors : Wang M; School of Acupuncture and Bone, Hubei University of Chinese Medicine, No. 1 Huangjiahu West Road, Hongshan District, Wuhan, Hubei, 430065, China.; Huang JB

Subjects: Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/therapy ; Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/metabolism ; Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/diagnostic imaging

• Source: Journal of orthopaedic surgery and research [J Orthop Surg Res] 2025 Mar 25; Vol. 20 (1), pp. 310. Date of Electronic Publication: 2025 Mar 25.Publisher: BioMed Central Country of Publication: England NLM ID: 101265112 Publication Model: Electronic Cited Medium:

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Nobiletin, as a Novel PDE4B Inhibitor, Alleviates Asthma Symptoms by Activating the cAMP-PKA-CREB Signaling Pathway.

• Authors : Zhang Y; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Yang Y

Subjects: Flavones*/Flavones*/Flavones*/pharmacology ; Flavones*/Flavones*/Flavones*/chemistry ; Asthma*/Asthma*/Asthma*/drug therapy

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Sep 27; Vol. 25 (19). Date of Electronic Publication: 2024 Sep 27.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium:

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Spatiotemporal orchestration of calcium-cAMP oscillations on AKAP/AC nanodomains is governed by an incoherent feedforward loop.

• Authors : Qiao L; Department of Pharmacology, University of California San Diego, San Diego, California, United States of America.; Department of Mechanical and Aerospace Engineering, University of California San Diego, San Diego, California, United States of America.

Subjects: Cyclic AMP*/Cyclic AMP*/Cyclic AMP*/metabolism ; A Kinase Anchor Proteins*/A Kinase Anchor Proteins*/A Kinase Anchor Proteins*/metabolism ; A Kinase Anchor Proteins*/A Kinase Anchor Proteins*/A Kinase Anchor Proteins*/chemistry

• Source: PLoS computational biology [PLoS Comput Biol] 2024 Oct 31; Vol. 20 (10), pp. e1012564. Date of Electronic Publication: 2024 Oct 31 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection

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The Protective Role of Intermedin in Contrast-Induced Acute Kidney Injury: Enhancing Peritubular Capillary Endothelial Cell Adhesion and Integrity Through the cAMP/Rac1 Pathway.

• Authors : Gao T; The Second Clinical Medical College, Shanxi Medical University, Taiyuan 030000, China.; Gu R

Subjects: Acute Kidney Injury*/Acute Kidney Injury*/Acute Kidney Injury*/chemically induced ; Acute Kidney Injury*/Acute Kidney Injury*/Acute Kidney Injury*/metabolism ; Acute Kidney Injury*/Acute Kidney Injury*/Acute Kidney Injury*/pathology

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Oct 16; Vol. 25 (20). Date of Electronic Publication: 2024 Oct 16.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium:

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Increase in bile acids after sleeve gastrectomy improves metabolism by activating GPBAR1 to increase cAMP in mice with nonalcoholic fatty liver disease.

• Authors : Li G; Department of Gastrointestinal Hepatobiliary Surgery, The Affiliated Hospital of Hangzhou Normal University, Hangzhou City, China.; Xu X

Subjects: Receptors, G-Protein-Coupled*/Receptors, G-Protein-Coupled*/Receptors, G-Protein-Coupled*/metabolism ; Receptors, G-Protein-Coupled*/Receptors, G-Protein-Coupled*/Receptors, G-Protein-Coupled*/genetics ; Non-alcoholic Fatty Liver Disease*/Non-alcoholic Fatty Liver Disease*/Non-alcoholic Fatty Liver Disease*/metabolism

• Source: Immunity, inflammation and disease [Immun Inflamm Dis] 2024 Jul; Vol. 12 (7), pp. e1149.Publisher: John Wiley and Sons Ltd Country of Publication: England NLM ID: 101635460 Publication Model: Print Cited Medium:

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MnO 2 and roflumilast-loaded probiotic membrane vesicles mitigate experimental colitis by synergistically augmenting cAMP in macrophage.

• Authors : Song C; State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing, 210093, China.; Wu J

Subjects: Aminopyridines*/Aminopyridines*/Aminopyridines*/pharmacology ; Cyclic AMP*/Cyclic AMP*/Cyclic AMP*/metabolism ; Probiotics*/Probiotics*/Probiotics*/pharmacology

• Source: Journal of nanobiotechnology [J Nanobiotechnology] 2024 May 28; Vol. 22 (1), pp. 294. Date of Electronic Publication: 2024 May 28.Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium:

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A predictive computational model reveals that GIV/girdin serves as a tunable valve for EGFR-stimulated cyclic AMP signals

• Authors : Getz, Michael; Swanson, Lee; Sahoo, Debashish

Subjects: Biochemistry and Cell Biology; Biological Sciences; 1.1 Normal biological development and functioning

• Source: Molecular Biology of the Cell. 30(13)

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A Mutation in the Transmembrane Domain of Adenylate Cyclase 3 Impairs Enzymatic Function to Cause Sex‐Specific Depression‐ and Anxiety‐Like Behaviors and Food Seeking in a Rat Model.

• Authors : Fitzpatrick, Mackenzie K.¹ (AUTHOR); Dyson, Christina² (AUTHOR); Beeson, Angela¹ (AUTHOR)

• Source: Genes, Brain & Behavior. Jun2025, Vol. 24 Issue 3, p1-14. 14p.

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