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Academic Journal

Linsitinib inhibits IGF-1-induced cell proliferation and hyaluronic acid secretion by suppressing PI3K/Akt and ERK pathway in orbital fibroblasts from patients with thyroid-associated ophthalmopathy.

Authors : Lee JY; Department of Pathology, Institute of Hansen's Disease, College of Medicine, The Catholic University of Korea, Seoul, Korea.; Lee SB

Subjects: Graves Ophthalmopathy*/Graves Ophthalmopathy*/Graves Ophthalmopathy*/drug therapy ; Graves Ophthalmopathy*/Graves Ophthalmopathy*/Graves Ophthalmopathy*/metabolism ; Graves Ophthalmopathy*/Graves Ophthalmopathy*/Graves Ophthalmopathy*/pathology

Source: PloS one [PLoS One] 2024 Dec 18; Vol. 19 (12), pp. e0311093. Date of Electronic Publication: 2024 Dec 18 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Synthesis and effect of 4-acetylphenylamine-based imidazole derivatives on migration and growth of 3D cultures of breast, prostate and brain cancer cells.

Authors : Golcienė B; Kaunas University of Technology, Radvilėnų Rd. 19, Kaunas, LT-50254, Lithuania.; Vaickelionienė R

Subjects: Imidazoles*/Imidazoles*/Imidazoles*/pharmacology ; Imidazoles*/Imidazoles*/Imidazoles*/chemistry ; Imidazoles*/Imidazoles*/Imidazoles*/chemical synthesis

Source: Scientific reports [Sci Rep] 2024 Nov 14; Vol. 14 (1), pp. 28065. Date of Electronic Publication: 2024 Nov 14.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Metformin Impairs Linsitinib Anti-Tumor Effect on Ovarian Cancer Cell Lines.

Authors : Almeida-Nunes DL; Associate Laboratory i4HB-Institute for Health and Bioeconomy, University Institute of Health Sciences-CESPU, 4585-116 Gandra, Portugal.; UCIBIO-Applied Molecular Biosciences Unit, Toxicologic Pathology Research Laboratory, University Institute of Health Sciences (1H-TOXRUN, IUCS-CESPU), 4585-116 Gandra, Portugal.

Subjects: Metformin*/Metformin*/Metformin*/pharmacology ; Ovarian Neoplasms*/Ovarian Neoplasms*/Ovarian Neoplasms*/drug therapy ; Ovarian Neoplasms*/Ovarian Neoplasms*/Ovarian Neoplasms*/metabolism

Source: International journal of molecular sciences [Int J Mol Sci] 2024 Nov 06; Vol. 25 (22). Date of Electronic Publication: 2024 Nov 06.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Effects of imidazole derivatives on cellular proliferation and apoptosis in myeloid leukemia.

Authors : Nadeem BB; Department of Biomedicine, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan.; Bibi A

Subjects: Imidazoles*/Imidazoles*/Imidazoles*/pharmacology ; Apoptosis*/Apoptosis*/Apoptosis*/drug effects ; Cell Proliferation*/Cell Proliferation*/Cell Proliferation*/drug effects

Source: BMC cancer [BMC Cancer] 2024 Sep 28; Vol. 24 (1), pp. 1200. Date of Electronic Publication: 2024 Sep 28.Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407

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Academic Journal

Exploring the therapeutic potential of a novel series of imidazothiadiazoles targeting focal adhesion kinase (FAK) for pancreatic cancer treatment: synthesis, mechanistic insights and promising antitumor and safety profile.

Authors : Pecoraro C; Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Palermo, Italy.; Carbone D

Subjects: Pancreatic Neoplasms*/Pancreatic Neoplasms*/Pancreatic Neoplasms*/drug therapy ; Pancreatic Neoplasms*/Pancreatic Neoplasms*/Pancreatic Neoplasms*/pathology ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology

Source: Journal of drug targeting [J Drug Target] 2024 Dec; Vol. 32 (10), pp. 1278-1294. Date of Electronic Publication: 2024 Aug 02.Publisher: Informa Healthcare Country of Publication: England NLM ID: 9312476 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Synthesis and Antiproliferative Evaluation of 2-Deoxy- N -glycosylbenzotriazoles/imidazoles.

Authors : Garton CS; Department of Chemistry, Farmingdale State College-SUNY, 2350 Broadhollow Rd, Farmingdale, NY 11735, USA.; DeRose NK

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*chemical synthesis ; Cell Proliferation/Cell Proliferation/Cell Proliferation/*drug effects ; Imidazoles/Imidazoles/Imidazoles/*chemical synthesis

Source: Molecules (Basel, Switzerland) [Molecules] 2021 Jun 19; Vol. 26 (12). Date of Electronic Publication: 2021 Jun 19.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Impaired Proliferation of CD8 + T Cells Stimulated with Monocyte-Derived Dendritic Cells Previously Matured with Thapsigargin-Stimulated LAD2 Human Mast Cells.

Authors : Kalkusova K; Department of Immunology Second Faculty of Medicine Charles University and University Hospital Motol, Prague, Czech Republic.; Taborska P

Subjects: Dendritic Cells*/Dendritic Cells*/Dendritic Cells*/immunology ; Dendritic Cells*/Dendritic Cells*/Dendritic Cells*/drug effects ; Dendritic Cells*/Dendritic Cells*/Dendritic Cells*/metabolism

Source: Journal of immunology research [J Immunol Res] 2024 Jul 18; Vol. 2024, pp. 5537948. Date of Electronic Publication: 2024 Jul 18 (Print Publication: 2024).Publisher: Wiley Country of Publication: Egypt NLM ID: 101627166 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-7156

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Academic Journal

Complex crystal structure determination and anti-non-small-cell lung cancer activity of the Hsp90 N inhibitor Debio0932.

Authors : Qin W; Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Shaanxi Key Laboratory of Brain Disorders, Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an 710021, People's Republic of China.; Yu F

Subjects: Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemistry ; Benzodioxoles*/Benzodioxoles*/Benzodioxoles*/chemistry ; Benzodioxoles*/Benzodioxoles*/Benzodioxoles*/pharmacology

Source: Acta crystallographica. Section D, Structural biology [Acta Crystallogr D Struct Biol] 2021 Jan 01; Vol. 77 (Pt 1), pp. 86-97. Date of Electronic Publication: 2021 Jan 01.Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101676043 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Synthesis, Structure and Cytotoxicity Testing of Novel 7-(4,5-dihydro-1 H -imidazol-2-yl)-2-aryl-6,7-dihydro-2 H -imidazo[2,1- c ][1,2,4]triazol-3(5 H )-Imine Derivatives.

Authors : Balewski Ł; Department of Chemical Technology of Drugs, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.; Sączewski F

Subjects: Cell Proliferation/Cell Proliferation/Cell Proliferation/*drug effects ; Cytotoxins/Cytotoxins/Cytotoxins/*chemical synthesis ; Imidazoles/Imidazoles/Imidazoles/*chemical synthesis

Source: Molecules (Basel, Switzerland) [Molecules] 2020 Dec 14; Vol. 25 (24). Date of Electronic Publication: 2020 Dec 14.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Search for ABCB1 Modulators Among 2-Amine-5-Arylideneimidazolones as a New Perspective to Overcome Cancer Multidrug Resistance.

Authors : Kaczor A; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland.; Nové M

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Cell Proliferation/Cell Proliferation/Cell Proliferation/*drug effects ; Drug Resistance, Neoplasm/Drug Resistance, Neoplasm/Drug Resistance, Neoplasm/*genetics

Source: Molecules (Basel, Switzerland) [Molecules] 2020 May 11; Vol. 25 (9). Date of Electronic Publication: 2020 May 11.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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فلترة النتائج

Linsitinib inhibits IGF-1-induced cell proliferation and hyaluronic acid secretion by suppressing PI3K/Akt and ERK pathway in orbital fibroblasts from patients with thyroid-associated ophthalmopathy.

Synthesis and effect of 4-acetylphenylamine-based imidazole derivatives on migration and growth of 3D cultures of breast, prostate and brain cancer cells.

Metformin Impairs Linsitinib Anti-Tumor Effect on Ovarian Cancer Cell Lines.

Effects of imidazole derivatives on cellular proliferation and apoptosis in myeloid leukemia.

Exploring the therapeutic potential of a novel series of imidazothiadiazoles targeting focal adhesion kinase (FAK) for pancreatic cancer treatment: synthesis, mechanistic insights and promising antitumor and safety profile.

Synthesis and Antiproliferative Evaluation of 2-Deoxy- N -glycosylbenzotriazoles/imidazoles.

Impaired Proliferation of CD8 + T Cells Stimulated with Monocyte-Derived Dendritic Cells Previously Matured with Thapsigargin-Stimulated LAD2 Human Mast Cells.

Complex crystal structure determination and anti-non-small-cell lung cancer activity of the Hsp90 N inhibitor Debio0932.

Synthesis, Structure and Cytotoxicity Testing of Novel 7-(4,5-dihydro-1 H -imidazol-2-yl)-2-aryl-6,7-dihydro-2 H -imidazo[2,1- c ][1,2,4]triazol-3(5 H )-Imine Derivatives.

Search for ABCB1 Modulators Among 2-Amine-5-Arylideneimidazolones as a New Perspective to Overcome Cancer Multidrug Resistance.

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