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The sensitivity to Hsp90 inhibitors of both normal and oncogenically transformed cells is determined by the equilibrium between cellular quiescence and activity.

• Authors : Echeverria, Pablo C.¹; Bhattacharya, Kaushik¹; Joshi, Abhinav¹

• Source: PLoS ONE. 2/6/2019, Vol. 14 Issue 2, p1-20. 20p.

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Heat Shock Protein 90 (HSP90) Inhibitors as Anticancer Medicines: A Review on the Computer-Aided Drug Discovery Approaches over the Past Five Years.

• Authors : Magwenyane, Ayanda M.¹ (AUTHOR); Ugbaja, Samuel C.¹ (AUTHOR); Amoako, Daniel G.^1,2 (AUTHOR)

• Source: Computational & Mathematical Methods in Medicine. 5/31/2022, p1-20. 20p.

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Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors.

• Authors : Smith, J R¹; Clarke, P A¹; de Billy, E¹

• Source: Oncogene. 1/15/2009, Vol. 28 Issue 2, p157-169. 13p. 5 Black and White Photographs, 1 Diagram, 2 Charts, 2 Graphs.

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Discovery of Novel 17-Phenylethylaminegeldanamycin Derivatives as Potent Hsp90 Inhibitors.

• Authors : Li, Zhenyu¹; Jia, Lejiao²; Wang, Jifeng^3,4

• Source: Chemical Biology & Drug Design. Feb2015, Vol. 85 Issue 2, p181-188. 8p.

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Priming with HDAC Inhibitors Sensitizes Ovarian Cancer Cells to Treatment with Cisplatin and HSP90 Inhibitors.

• Authors : Rodrigues Moita, Ana J.¹ (AUTHOR) ; Bandolik, Jan J.¹ (AUTHOR) ; Hansen, Finn K.² (AUTHOR)

• Source: International Journal of Molecular Sciences. Nov2020, Vol. 21 Issue 21, p8300. 1p.

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Synergistic activity of Hsp90 inhibitors and anticancer agents in pancreatic cancer cell cultures.

• Authors : Daunys, Simonas¹; Matulis, Daumantas²; Petrikaitė, Vilma^2,3

• Source: Scientific Reports. 11/7/2019, Vol. 9 Issue 1, pN.PAG-N.PAG. 1p.

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Computational Analysis of HSP90 Isoforms Identifies Differential Sensitivity Towards Specific Inhibitors.

• Authors : Ravula, Shravanthi¹; Mullaguri, Sai Charitha¹; Sivan, Sree Kanth²

• Source: Current Trends in Biotechnology & Pharmacy. Jan2025, Vol. 19 Issue 1, p2204-2210. 7p.

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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors.

• Authors : Kamal, Adeela¹; Thao, Lia¹; Sensintaffar, John¹

• Source: Nature. 9/25/2003, Vol. 425 Issue 6956, p407. 4p.

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A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties.

• Authors : Atlante, Sandra; Cis, Luca; Pirolli, Davide

Subjects: HEAT shock proteins; VIRTUAL high-throughput screening (Drug development); MESENCHYMAL stem cells

• Source: Aging Cell; Jul2025, Vol. 24 Issue 7, p1-20, 20p

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Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction.

• Authors : Stingl, L.¹; Stühmer, T.²; Chatterjee, M.²

• Source: British Journal of Cancer. 5/25/2010, Vol. 102 Issue 11, p1578-1591. 14p. 2 Diagrams, 1 Chart, 7 Graphs.

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