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Academic Journal

Trabectedin Induces Synthetic Lethality via the p53-Dependent Apoptotic Pathway in Ovarian Cancer Cells Without BRCA Mutations When Used in Combination with Niraparib.

Authors : Kang B; Department of Chemistry, College of Natural Science, Kyungpook National University, Daegu 41944, Republic of Korea.; Lee SJ

Subjects: Apoptosis*/Apoptosis*/Apoptosis*/drug effects ; Tumor Suppressor Protein p53*/Tumor Suppressor Protein p53*/Tumor Suppressor Protein p53*/metabolism ; Tumor Suppressor Protein p53*/Tumor Suppressor Protein p53*/Tumor Suppressor Protein p53*/genetics

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Mar 24; Vol. 26 (7). Date of Electronic Publication: 2025 Mar 24.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Effective Radiosensitization of HNSCC Cell Lines by DNA-PKcs Inhibitor AZD7648 and PARP Inhibitors Talazoparib and Niraparib.

Authors : Mentzel J; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-Europäische Metropolregion Nürnberg (CCC ER-EMN), 91054 Erlangen, Germany.

Subjects: Phthalazines*/Phthalazines*/Phthalazines*/pharmacology ; Indazoles*/Indazoles*/Indazoles*/pharmacology ; Piperidines*/Piperidines*/Piperidines*/pharmacology

Source: International journal of molecular sciences [Int J Mol Sci] 2024 May 22; Vol. 25 (11). Date of Electronic Publication: 2024 May 22.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Entrectinib Induces Apoptosis and Inhibits the Epithelial-Mesenchymal Transition in Gastric Cancer with NTRK Overexpression.

Authors : Sohn SH; Hallym Translational Research Institute, Hallym University Sacred Heart Hospital, Anyang 14066, Korea.; Sul HJ

Subjects: Apoptosis*/Apoptosis*/Apoptosis*/drug effects ; Apoptosis*/Apoptosis*/Apoptosis*/genetics ; Epithelial-Mesenchymal Transition*/Epithelial-Mesenchymal Transition*/Epithelial-Mesenchymal Transition*/drug effects

Source: International journal of molecular sciences [Int J Mol Sci] 2021 Dec 30; Vol. 23 (1). Date of Electronic Publication: 2021 Dec 30.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Combined inhibition of AURKA and HSF1 suppresses proliferation and promotes apoptosis in hepatocellular carcinoma by activating endoplasmic reticulum stress.

Authors : Shen Z; The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, 42 Baiziting, Nanjing, Jiangsu, 210009, China.; Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, 210002, Nanjing, Jiangsu, China.

Subjects: Apoptosis/Apoptosis/Apoptosis/*genetics ; Aurora Kinase A/Aurora Kinase A/Aurora Kinase A/*genetics ; Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/*genetics

Source: Cellular oncology (Dordrecht, Netherlands) [Cell Oncol (Dordr)] 2021 Oct; Vol. 44 (5), pp. 1035-1049. Date of Electronic Publication: 2021 Jun 26.Publisher: Springer Country of Publication: Netherlands NLM ID: 101552938 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Precursor B-ALL Cell Lines Differentially Respond to SYK Inhibition by Entospletinib.

Authors : Sender S; Division of Medicine, Department of Hematology, Oncology and Palliative Medicine, University of Rostock, 18057 Rostock, Germany.; Sekora A

Subjects: Apoptosis/Apoptosis/Apoptosis/*drug effects ; Cell Proliferation/Cell Proliferation/Cell Proliferation/*drug effects ; Indazoles/Indazoles/Indazoles/*pharmacology

Source: International journal of molecular sciences [Int J Mol Sci] 2021 Jan 08; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 08.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

The MEK-ERK-MST1 Axis Potentiates the Activation of the Extrinsic Apoptotic Pathway during GDC-0941 Treatment in Jurkat T Cells.

Authors : Nováková J; BIOCEV, Institute of Microbiology, v.v.i., The Czech Academy of Sciences, Průmyslová 595, 252 50 Vestec, Czech Republic. .; Talacko P

Subjects: Apoptosis/Apoptosis/Apoptosis/*drug effects ; Hepatocyte Growth Factor/Hepatocyte Growth Factor/Hepatocyte Growth Factor/*metabolism ; Indazoles/Indazoles/Indazoles/*pharmacology

Source: Cells [Cells] 2019 Feb 21; Vol. 8 (2). Date of Electronic Publication: 2019 Feb 21.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Print ISSN: 2073-4409 (Print)

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Academic Journal

YC-1 induces apoptosis of human renal carcinoma A498 cells in vitro and in vivo through activation of the JNK pathway.

Authors : Wu SY; Department of Pharmacology, College of Medicine, Pharmacological Institute, National Taiwan University, Taipei, Taiwan.; Pan SL

Subjects: Apoptosis/Apoptosis/Apoptosis/*drug effects ; Carcinoma, Renal Cell/Carcinoma, Renal Cell/Carcinoma, Renal Cell/*drug therapy ; Enzyme Activators/Enzyme Activators/Enzyme Activators/*pharmacology

Source: British journal of pharmacology [Br J Pharmacol] 2008 Oct; Vol. 155 (4), pp. 505-13. Date of Electronic Publication: 2008 Jul 21.Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0007-1188 (Print)

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Academic Journal

Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell Leukemia/Lymphoma by Suppressing the ERK1/2 Pathway.

Authors : Chang G; Department of Hematology, Anhui Medical University, Hefei 230032, China.; Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.

Subjects: Apoptosis/Apoptosis/Apoptosis/*drug effects ; Cell Cycle Checkpoints/Cell Cycle Checkpoints/Cell Cycle Checkpoints/*drug effects ; Leukemia, T-Cell/Leukemia, T-Cell/Leukemia, T-Cell/*enzymology

Source: BioMed research international [Biomed Res Int] 2017; Vol. 2017, pp. 9872073. Date of Electronic Publication: 2017 Jul 12.Publisher: Wiley Country of Publication: United States NLM ID: 101600173 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Apoptotic efficacy of etomoxir in human acute myeloid leukemia cells. Cooperation with arsenic trioxide and glycolytic inhibitors, and regulation by oxidative stress and protein kinase activities.

Authors : Estañ MC; Centro de Investigaciones Biológicas (CIB), Consejo Superior de Investigaciones Científicas (CSIC), Ramiro de Maeztu 9, Madrid, Spain.; Calviño E

Subjects: Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/*therapeutic use ; Apoptosis/Apoptosis/Apoptosis/*drug effects ; Arsenicals/Arsenicals/Arsenicals/*therapeutic use

Source: PloS one [PLoS One] 2014 Dec 15; Vol. 9 (12), pp. e115250. Date of Electronic Publication: 2014 Dec 15 (Print Publication: 2014).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

PI3K inhibition enhances doxorubicin-induced apoptosis in sarcoma cells.

Authors : Marklein D; Institute of Human Genetics, University Medical Center, Goettingen, Germany.; Graab U

Subjects: Phosphoinositide-3 Kinase Inhibitors*; Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/*pharmacology ; Apoptosis/Apoptosis/Apoptosis/*drug effects

Source: PloS one [PLoS One] 2012; Vol. 7 (12), pp. e52898. Date of Electronic Publication: 2012 Dec 31.Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet

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نتائج البحث

فلترة النتائج

Trabectedin Induces Synthetic Lethality via the p53-Dependent Apoptotic Pathway in Ovarian Cancer Cells Without BRCA Mutations When Used in Combination with Niraparib.

Effective Radiosensitization of HNSCC Cell Lines by DNA-PKcs Inhibitor AZD7648 and PARP Inhibitors Talazoparib and Niraparib.

Entrectinib Induces Apoptosis and Inhibits the Epithelial-Mesenchymal Transition in Gastric Cancer with NTRK Overexpression.

Combined inhibition of AURKA and HSF1 suppresses proliferation and promotes apoptosis in hepatocellular carcinoma by activating endoplasmic reticulum stress.

Precursor B-ALL Cell Lines Differentially Respond to SYK Inhibition by Entospletinib.

The MEK-ERK-MST1 Axis Potentiates the Activation of the Extrinsic Apoptotic Pathway during GDC-0941 Treatment in Jurkat T Cells.

YC-1 induces apoptosis of human renal carcinoma A498 cells in vitro and in vivo through activation of the JNK pathway.

Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell Leukemia/Lymphoma by Suppressing the ERK1/2 Pathway.

Apoptotic efficacy of etomoxir in human acute myeloid leukemia cells. Cooperation with arsenic trioxide and glycolytic inhibitors, and regulation by oxidative stress and protein kinase activities.

PI3K inhibition enhances doxorubicin-induced apoptosis in sarcoma cells.

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