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Dual Opioid-Neuropeptide FF Small Molecule Ligands Demonstrate Analgesia with Reduced Tolerance Liabilities.

• Authors : Mottinelli M; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA.; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA.

Subjects: Analgesics, Opioid*/Analgesics, Opioid*/Analgesics, Opioid*/pharmacology ; Analgesics, Opioid*/Analgesics, Opioid*/Analgesics, Opioid*/chemistry ; Receptors, Neuropeptide*/Receptors, Neuropeptide*/Receptors, Neuropeptide*/antagonists & inhibitors

• Source: Molecules (Basel, Switzerland) [Molecules] 2025 Jul 03; Vol. 30 (13). Date of Electronic Publication: 2025 Jul 03.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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The Identification of Opioid Receptors and Peptide Precursors in Human DRG Neurons Expressing Pain-Signaling Molecules Confirms Their Potential as Analgesic Targets.

• Authors : Mousa SA; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anaesthesiology and Intensive Care Medicine, Charité Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany.; Shaqura M

Subjects: Ganglia, Spinal*/Ganglia, Spinal*/Ganglia, Spinal*/metabolism ; Pain*/Pain*/Pain*/metabolism ; Pain*/Pain*/Pain*/drug therapy

• Source: Cells [Cells] 2025 May 11; Vol. 14 (10). Date of Electronic Publication: 2025 May 11.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Ketamine as part of multi-modal analgesia may reduce opioid requirements following cardiac surgery: a retrospective observational cohort study.

• Authors : Hall J; Cardiothoracic Critical Care, Department of Cardiac Surgery, NYU Langone, Long Island Hospital, 259 1st Street, Mineola, New York, 11501, USA. .; Chung J

Subjects: Ketamine*/Ketamine*/Ketamine*/administration & dosage ; Ketamine*/Ketamine*/Ketamine*/therapeutic use ; Pain, Postoperative*/Pain, Postoperative*/Pain, Postoperative*/drug therapy

• Source: Journal of cardiothoracic surgery [J Cardiothorac Surg] 2025 Apr 03; Vol. 20 (1), pp. 178. Date of Electronic Publication: 2025 Apr 03.Publisher: BioMed Central Country of Publication: England NLM ID: 101265113 Publication Model: Electronic Cited Medium: Internet ISSN: 1749-8090

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Effects of Biased Analogues of the Kappa Opioid Receptor Agonist, U50,488, in Preclinical Models of Pain and Side Effects.

• Authors : van de Wetering R; School of Biological Sciences, Centre for Biodiscovery, Victoria University of Wellington, Wellington 6012, New Zealand.; Vu LY

Subjects: Receptors, Opioid, kappa*/Receptors, Opioid, kappa*/Receptors, Opioid, kappa*/agonists ; Receptors, Opioid, kappa*/Receptors, Opioid, kappa*/Receptors, Opioid, kappa*/metabolism ; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer*/3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer*/3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer*/pharmacology

• Source: Molecules (Basel, Switzerland) [Molecules] 2025 Jan 29; Vol. 30 (3). Date of Electronic Publication: 2025 Jan 29.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Development and In Vivo evaluation of liposomal fentanyl nanocarriers using thin-film hydration and AI-based characterization for enhanced analgesic efficacy in anesthesia.

• Authors : Zare-Zardini H; Department of Biomedical Engineering, Meybod University, Meybod, Iran. .; Saberian E

Subjects: Fentanyl*/Fentanyl*/Fentanyl*/administration & dosage ; Fentanyl*/Fentanyl*/Fentanyl*/pharmacology ; Fentanyl*/Fentanyl*/Fentanyl*/chemistry

• Source: Scientific reports [Sci Rep] 2025 Oct 14; Vol. 15 (1), pp. 35829. Date of Electronic Publication: 2025 Oct 14.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Respiratory and Cardiovascular Activity of LENART01, an Analgesic Dermorphin-Ranatensin Hybrid Peptide, in Anesthetized Rats.

• Authors : Wojciechowski P; Department of Respiration Physiology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Pawińskiego 5, 02-106 Warsaw, Poland.; Zając D

Subjects: Opioid Peptides*/Opioid Peptides*/Opioid Peptides*/pharmacology ; Opioid Peptides*/Opioid Peptides*/Opioid Peptides*/chemistry ; Analgesics, Opioid*/Analgesics, Opioid*/Analgesics, Opioid*/pharmacology

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 Jul 25; Vol. 26 (15). Date of Electronic Publication: 2025 Jul 25.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Oral and injectable opioid agonist treatments for people who use street opioids: a systematic literature review and network meta-analysis.

• Authors : Bansback, Nick^1,2 (AUTHOR); Tam, Alexander C.T.² (AUTHOR); Palis, Heather^1,3 (AUTHOR)

• Source: BMC Public Health. 8/30/2025, Vol. 25 Issue 1, p1-16. 16p.

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Desirable treatment or a problematic drug scene? - An interview study of patients' and professionals' views on the risks and benefits of liberalized opioid agonist treatment

• Authors : Nordgren, Johan; Richert, Torkel

Subjects: Humans; Female; Opioid-Related Disorders / drug therapy

• Source: Harm Reduction Journal. 22(1)

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Opioid Affinity of Diazacyclic Peptidomimetic Compounds Derived from Reduced Polyamides.

• Authors : Chaudhari, Prakash¹ (AUTHOR); Bunnell, Ashley^1,2 (AUTHOR); Yegambaram, Manivannan^1,3 (AUTHOR)

• Source: International Journal of Molecular Sciences. Sep2025, Vol. 26 Issue 17, p8249. 8p.

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アロステリック調節薬による μ オピオイド受容体の活 性化機構.

• Authors : 今井駿輔¹ ; 嶋田一夫^1,2

• Source: Seibutsu Butsuri. 2025, Vol. 65 Issue 3, p145-149. 5p.

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