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  • 1-10 ل  45 نتائج ل ""Progranulins""

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Subject : alzheimer disease
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Academic Journal

Development of AL101 (GSK4527226), a progranulin-elevating monoclonal antibody, as a potential treatment for Alzheimer's disease.

  • Authors : Budda B; Alector, Inc, 131 Oyster Point Blvd, #600, South San Francisco, CA, 94080, USA. .; Mitra A

Subjects: Progranulins*/Progranulins*/Progranulins*/metabolism ; Progranulins*/Progranulins*/Progranulins*/blood ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/drug therapy

  • Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2025 Jul 25; Vol. 17 (1), pp. 174. Date of Electronic Publication: 2025 Jul 25.Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Microglial Progranulin: Involvement in Alzheimer's Disease and Neurodegenerative Diseases.

  • Authors : Mendsaikhan A; Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu 520-2192, Japan. .; Tooyama I

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*metabolism ; Microglia/Microglia/Microglia/*metabolism ; Progranulins/Progranulins/Progranulins/*metabolism

  • Source: Cells [Cells] 2019 Mar 11; Vol. 8 (3). Date of Electronic Publication: 2019 Mar 11.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Print ISSN: 2073-4409 (Print)

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Academic Journal

Serum progranulin is not associated with rs5848 polymorphism in Korean patients with neurodegenerative diseases.

  • Authors : Jung NY; Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Republic of Korea.; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.

Subjects: Polymorphism, Single Nucleotide*; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*genetics ; Progranulins/Progranulins/Progranulins/*blood

  • Source: PloS one [PLoS One] 2022 Jan 27; Vol. 17 (1), pp. e0261007. Date of Electronic Publication: 2022 Jan 27 (Print Publication: 2022).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

AZP2006, a new promising treatment for Alzheimer's and related diseases.

  • Authors : Callizot N; Alzprotect, Parc Eurasanté, 85C rue Nelson Mandela, 59120, Loos, France. .; Neuro-Sys, 410 Chemin Départemental 60, 13120, Gardanne, France. .

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*drug therapy ; Piperazines/Piperazines/Piperazines/*therapeutic use; Aging/Aging/Aging/pathology

  • Source: Scientific reports [Sci Rep] 2021 Aug 19; Vol. 11 (1), pp. 16806. Date of Electronic Publication: 2021 Aug 19.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Repressor Element 1 Silencing Transcription Factor (REST) Governs Microglia-Like BV2 Cell Migration via Progranulin (PGRN).

  • Authors : Yu T; Shanghai Tenth People's Hospital of Tongji University, Tongji University, Middle Yanchang Rd. 301#, Jingan District, Shanghai, China 200072.; Lin Y

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*metabolism ; Cell Movement/Cell Movement/Cell Movement/*physiology ; Gene Expression Regulation/Gene Expression Regulation/Gene Expression Regulation/*physiology

  • Source: Neural plasticity [Neural Plast] 2020 Nov 25; Vol. 2020, pp. 8855822. Date of Electronic Publication: 2020 Nov 25 (Print Publication: 2020).Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 100883417 Publication Model: eCollection Cited Medium: Internet ISSN:

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Academic Journal

Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology.

  • Authors : Mendsaikhan A; Molecular Neuroscience Research Center, Shiga University of Medical Science, Seta, Otsu, Otsu, 520-2192, Japan.; Tooyama I

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*metabolism ; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*pathology ; Lysosomes/Lysosomes/Lysosomes/*metabolism

  • Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2019 Dec 21; Vol. 7 (1), pp. 215. Date of Electronic Publication: 2019 Dec 21.Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960

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Academic Journal

Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer's disease model mice.

  • Authors : Hosokawa M; Dementia research project, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.; Tanaka Y

Subjects: Haploinsufficiency* ; Loss of Function Mutation*; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*genetics

  • Source: Experimental animals [Exp Anim] 2018 Feb 09; Vol. 67 (1), pp. 63-70. Date of Electronic Publication: 2017 Aug 25.Publisher: Japanese Association for Laboratory Animal Science Country of Publication: Japan NLM ID: 9604830 Publication Model: Print-Electronic Cited

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Academic Journal

Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study.

Subjects: Alzheimer’s Disease Neuroimaging Initiative; Humans; Alzheimer Disease

  • Source: Translational Psychiatry. 15(1)

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Academic Journal

Progranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer's disease.

  • Authors : Van Kampen JM; Neurodyn Inc., Charlottetown, PE, Canada.; Dept. Biomedical Science, University of Prince Edward Island, Charlottetown, PE, Canada.

Subjects: Disease Models, Animal* ; Genetic Therapy* ; Plaque, Atherosclerotic*

  • Source: PloS one [PLoS One] 2017 Aug 24; Vol. 12 (8), pp. e0182896. Date of Electronic Publication: 2017 Aug 24 (Print Publication: 2017).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.

  • Authors : Minami SS; 1] Gladstone Institute of Neurological Disease, San Francisco, California, USA. [2] Department of Neurology, University of California, San Francisco, San Francisco, California, USA.; Min SW

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*metabolism ; Amyloid beta-Peptides/Amyloid beta-Peptides/Amyloid beta-Peptides/*metabolism ; Intercellular Signaling Peptides and Proteins/Intercellular Signaling Peptides and Proteins/Intercellular Signaling Peptides and Proteins/*metabolism

  • Source: Nature medicine [Nat Med] 2014 Oct; Vol. 20 (10), pp. 1157-64. Date of Electronic Publication: 2014 Sep 28.Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet

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  • 1-10 ل  45 نتائج ل ""Progranulins""