Source: Science (New York, N.Y.) [Science] 2019 Nov 01; Vol. 366 (6465), pp. 561.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium:

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MCT1-dependent lactate recycling is a metabolic vulnerability in colorectal cancer cells upon acquired resistance to anti-EGFR targeted therapy.

Authors : Richiardone, Elena; Al Roumi, Rim; Lardinois, Fanny

Subjects: Cetuximab; Colorectal cancer; KRAS

Source: Cancer Letters, 598, 217091 (2024-08-28)

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Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation.

Authors : Sacher, Adrian; LoRusso, Patricia; Patel, Manish R ...

Subjects: Antineoplastic Agents; KRAS protein, human; Proto-Oncogene Proteins p21(ras)

Source: New England Journal of Medicine, 389 (8), 710 - 721 (2023-08-24)

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Periodical

ONCOLOGY. Vitamin C could target some common cancers.

Authors : Kaiser J

Subjects: Ascorbic Acid/Ascorbic Acid/Ascorbic Acid/*therapeutic use ; Neoplasms/Neoplasms/Neoplasms/*drug therapy ; Vitamins/Vitamins/Vitamins/*therapeutic use

Source: Science (New York, N.Y.) [Science] 2015 Nov 06; Vol. 350 (6261), pp. 619.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium:

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Periodical

The littlest patient.

Authors : Couzin-Frankel J

Subjects: Mice* ; Xenograft Model Antitumor Assays*; Neoplasms, Experimental/Neoplasms, Experimental/Neoplasms, Experimental/*drug therapy

Source: Science (New York, N.Y.) [Science] 2014 Oct 03; Vol. 346 (6205), pp. 24-7. Date of Electronic Publication: 2014 Oct 02.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Periodical

Integrin β3 links therapy resistance and cancer stem cell properties.

Authors : Kannan N; Nguyen LV; Eaves CJ

Subjects: Drug Resistance, Neoplasm*; ErbB Receptors/ErbB Receptors/ErbB Receptors/*antagonists & inhibitors ; Integrin beta3/Integrin beta3/Integrin beta3/*metabolism

Source: Nature cell biology [Nat Cell Biol] 2014 May; Vol. 16 (5), pp. 397-9.Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print Cited Medium: Internet ISSN:

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Periodical

RAF-isotype switching: from B to C through PDE.

Authors : Lau E; Ronai Z

Subjects: MAP Kinase Signaling System*; Cyclic Nucleotide Phosphodiesterases, Type 4/Cyclic Nucleotide Phosphodiesterases, Type 4/Cyclic Nucleotide Phosphodiesterases, Type 4/*physiology ; Proto-Oncogene Proteins B-raf/Proto-Oncogene Proteins B-raf/Proto-Oncogene Proteins B-raf/*metabolism

Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2011 May; Vol. 18 (5), pp. 517-8.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print Cited Medium: Internet ISSN:

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Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis.

Authors : Tran, Phuoc T.; Shroff, Emelyn H.; Burns, Timothy F.

Subjects: Adenocarcinoma/genetics/metabolism; Animals; Cell Aging/genetics

Source: PLoS Genetics, 8 (5), e1002650 (2012)

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Periodical

Cancer: A Ras and NF-kappaB pas de deux.

Authors : Chenette EJ

Subjects: Carcinoma, Non-Small-Cell Lung/Carcinoma, Non-Small-Cell Lung/Carcinoma, Non-Small-Cell Lung/*drug therapy ; Lung Neoplasms/Lung Neoplasms/Lung Neoplasms/*drug therapy ; Proto-Oncogene Proteins/Proto-Oncogene Proteins/Proto-Oncogene Proteins/*genetics

Source: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2009 Dec; Vol. 8 (12), pp. 932.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124171 Publication Model: Print Cited Medium: Internet ISSN: 1474-1784

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نتائج البحث

فلترة النتائج

Oncogenic mutant KRAS inhibition through oxidation at cysteine 118.

After decades, progress against an 'undruggable' cancer target.

MCT1-dependent lactate recycling is a metabolic vulnerability in colorectal cancer cells upon acquired resistance to anti-EGFR targeted therapy.

Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation.

ONCOLOGY. Vitamin C could target some common cancers.

The littlest patient.

Integrin β3 links therapy resistance and cancer stem cell properties.

RAF-isotype switching: from B to C through PDE.

Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis.

Cancer: A Ras and NF-kappaB pas de deux.

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