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First approved drug for mitochondrial disease raises hopes for more.

• Authors : Leslie M

Subjects: Mitochondrial Diseases*/Mitochondrial Diseases*/Mitochondrial Diseases*/drug therapy ; Mitochondrial Diseases*/Mitochondrial Diseases*/Mitochondrial Diseases*/genetics ; Drug Approval*

• Source: Science (New York, N.Y.) [Science] 2025 Oct 09; Vol. 390 (6769), pp. 114-115. Date of Electronic Publication: 2025 Oct 09.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Hypoxia as a therapy for mitochondrial disease.

• Authors : Jain, Isha H.^1,2,3; Zazzeron, Luca⁴; Goli, Rahul^1,2,3

• Source: Science (1880 to 2025). 4/1/2016, Vol. 352 Issue 6281, p54-61. 8p.

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Mutations causing mitochondrial disease:What is new and what challenges remain?

• Authors : Lightowlers, Robert N.¹; Taylor, Robert W.¹; Turnbull, Doug M.¹

• Source: Science (1880 to 2025). 9/25/2015, Vol. 349 Issue 6255, p1494-1499. 6p.

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Mitochondrial disease: Replace or edit?

• Authors : Adashi EY; Department of Medical Science, Brown University, Providence, RI, USA.; Rubenstein DS

Subjects: Gene Editing* ; Mitochondrial Replacement Therapy*; DNA, Mitochondrial/DNA, Mitochondrial/DNA, Mitochondrial/*genetics

• Source: Science (New York, N.Y.) [Science] 2021 Sep 10; Vol. 373 (6560), pp. 1200-1201. Date of Electronic Publication: 2021 Sep 09.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome.

• Authors : Johnson, Simon C.¹; Yanos, Melana E.^1,2; Kayser, Ernst-Bernhard³

• Source: Science (1880 to 2025). 12/20/2013, Vol. 342 Issue 6165, p1524-1528. 5p.

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A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations.

• Authors : Weiwei Fan^1,2; Waymire, Katrina G.^1,2; Narula, Navneet³

• Source: Science (1880 to 2025). 2/15/2008, Vol. 319 Issue 5865, p958-962. 5p. 1 Diagram, 4 Graphs.

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MITOCHONDRIA. Mitochondrial disease therapy from thin air?

• Authors : Shoubridge EA; Montreal Neurological Institute, Department of Human Genetics, McGill University, Montreal, Quebec, Canada. .

Subjects: Leigh Disease/Leigh Disease/Leigh Disease/*genetics ; Leigh Disease/Leigh Disease/Leigh Disease/*therapy ; Mitochondria/Mitochondria/Mitochondria/*metabolism

• Source: Science (New York, N.Y.) [Science] 2016 Apr 01; Vol. 352 (6281), pp. 31-2. Date of Electronic Publication: 2016 Mar 31.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Mitochondrial disease: Replace or edit?

• Authors : Adashi, Eli Y.; Rubenstein, Donald S.; Mossman, Jim A.

Subjects: ALLELES; MITOCHONDRIAL DNA; HAPLOTYPES

• Source: Science (1880 to 2025); 9/10/2021, Vol. 373 Issue 6560, p1200-1201, 2p, 2 Diagrams

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Mitochondrial disease therapy from thin air?

• Authors : Shoubridge, Eric A.

Subjects: MITOCHONDRIAL pathology; OXIDATIVE phosphorylation; ADENOSINE triphosphate

• Source: Science (1880 to 2025); 4/1/2016, Vol. 352 Issue 6281, p31-32, 2p

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Manipulating the Metazoan Mitochondrial Genome with Targeted Restriction Enzymes.

• Authors : Hong Xu¹; Detuca, Steven Z.¹; O'Farrell, Patrick H.¹

• Source: Science (1880 to 2025). 7/25/2008, Vol. 321 Issue 5888, p575-577. 3p. 3 Graphs.

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