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Study protocol: COPD-eosinophil-guided reduction of inhaled corticosteroids (COPERNICOS) : A randomized, double-blinded, multicenter, four-arm intervention clinical trial on eosinophil-guided time-updated person-specific reduction of inhaled corticosteroid therapy and prophylactic low dose Azithromycin therapy in patients with severe or very severe chronic obstructive pulmonary disease (COPD).

• Authors : Rønn C; Department of Internal Medicine, Copenhagen Respiratory Research, Copenhagen University Hospital - Gentofte, Hellerup, Denmark. .; Bonnesen B

Subjects: Azithromycin*/Azithromycin*/Azithromycin*/administration & dosage ; Azithromycin*/Azithromycin*/Azithromycin*/adverse effects ; Pulmonary Disease, Chronic Obstructive*/Pulmonary Disease, Chronic Obstructive*/Pulmonary Disease, Chronic Obstructive*/drug therapy

• Source: Trials [Trials] 2025 Sep 02; Vol. 26 (1), pp. 335. Date of Electronic Publication: 2025 Sep 02.Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215

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The effectiveness of dual-task exercises in individuals with chronic obstructive pulmonary disease: a study protocol for a randomized controlled trial.

• Authors : Ünlü, Begüm¹ (AUTHOR) ; Yıldız Özer, Aysel¹ (AUTHOR) ; Özmen, İpek² (AUTHOR)

• Source: Trials. 5/19/2025, Vol. 26 Issue 1, p1-12. 12p.

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Effects and mechanisms of supramaximal high-intensity interval training on extrapulmonary manifestations in people with and without chronic obstructive pulmonary disease (COPD-HIIT): study protocol for a multi-centre, randomized controlled trial

• Authors : Jakobsson, Johan; Burtin, Chris; Hedlund, Mattias

Subjects: Aerobic exercise; Cognitive aspects; High-intensity interval training

• Source: Trials. 25(1)

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Effect of 12-week head-down strong abdominal breathing on cognitive function in patients with stable chronic obstructive pulmonary disease: a single-centre randomised controlled trial protocol.

• Authors : Song, Feiyun¹ (AUTHOR); Ding, Kexin¹ (AUTHOR); Sun, Mingyun¹ (AUTHOR)

• Source: Trials. 5/30/2024, Vol. 25 Issue 1, p1-15. 15p.

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Standard vs. targeted oxygen therapy prehospitally for chronic obstructive pulmonary disease (STOP-COPD): study protocol for a randomised controlled trial.

• Authors : Jensen, Arne Sylvester Rønde^1,2 (AUTHOR) ; Valentin, Jan Brink³ (AUTHOR); Mulvad, Mathilde Gundgaard^1,4 (AUTHOR)

• Source: Trials. 1/25/2024, Vol. 25 Issue 1, p1-12. 12p.

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Effects of a physical exercise program on HIF-1α in people with Chronic Obstructive Pulmonary Disease living at high altitude: study protocol for a clinical trial.

• Authors : Villamil-Parra, Wilder^1,2 (AUTHOR) ; Cristancho-Mejía, Édgar² (AUTHOR); Ramon Torrella, Joan³ (AUTHOR)

• Source: Trials. 10/29/2023, Vol. 24 Issue 1, p1-13. 13p. 2 Diagrams, 2 Charts.

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Effects of multimodal exercise program on postural balance in patients with chronic obstructive pulmonary disease: study protocol for a randomized controlled trial.

• Authors : Daros dos Santos, Tamires¹ (AUTHOR); Pasqualoto, Adriane Schmidt¹ (AUTHOR); Cardoso, Dannuey Machado^2,3 (AUTHOR)

• Source: Trials. 8/15/2023, Vol. 24 Issue 1, p1-11. 11p. 2 Diagrams, 1 Chart.

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The IMPROVE trial: study protocol for a pragmatic cluster randomised controlled trial to assess the effectiveness of using lay health workers to improve uptake and completion of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease.

• Authors : Gilworth G; Academic Department of Rehabilitation Medicine, Faculty of Medicine and Health, University of Leeds, Sheffield, UK.; Harris K

Subjects: Pulmonary Disease, Chronic Obstructive* ; State Medicine*; Humans

• Source: Trials [Trials] 2024 Mar 19; Vol. 25 (1), pp. 194. Date of Electronic Publication: 2024 Mar 19.Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215

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Behaviour change techniques embedded in physical training protocol on exercise motivation and level of physical activity in individuals with COPD: study protocol for a randomized controlled trial.

• Authors : Basso, Fernanda Manenti¹ (AUTHOR); Araújo, Tiago de Almeida¹ (AUTHOR); Zopelari, Livia Maria Petilli¹ (AUTHOR)

• Source: Trials. 10/8/2025, Vol. 26 Issue 1, p1-13. 13p.

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Impact of corticosteroids on the duration of ventilatory support during severe acute exacerbations of chronic obstructive pulmonary disease in patients in the intensive care unit: a study protocol for a multicentre, randomized, placebo-controlled, double-blind trial

• Authors : Ferré, Alexis¹ (AUTHOR) ; Thille, Arnaud W.² (AUTHOR); Mekontso-Dessap, Armand³ (AUTHOR)

• Source: Trials. 3/26/2023, Vol. 24 Issue 1, p1-12. 12p. 1 Diagram, 1 Chart.

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