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Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease.

• Authors : Tenreiro, Sandra¹ ; Reimão-Pinto, Madalena M.¹; Antas, Pedro¹

• Source: PLoS Genetics. May2014, Vol. 10 Issue 5, p1-23. 23p.

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CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly.

• Authors : Sweeney, Katelyn M.^1,2 (AUTHOR); Chantarawong, Sapanna^1,2 (AUTHOR); Barbieri, Edward M.³ (AUTHOR)

• Source: PLoS Genetics. 2/5/2024, Vol. 20 Issue 2, p1-32. 32p.

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TDP-43 pathology in Drosophila induces glial-cell type specific toxicity that can be ameliorated by knock-down of SF2/SRSF1.

• Authors : Krupp, Sarah¹ (AUTHOR); Hubbard, Isabel¹ (AUTHOR); Tam, Oliver² (AUTHOR)

• Source: PLoS Genetics. 9/25/2023, Vol. 19 Issue 9, p1-21. 21p.

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Decreased Hsp90 activity protects against TDP-43 neurotoxicity in a C. elegans model of amyotrophic lateral sclerosis.

• Authors : Garcia-Toscano, Laura^1,2 (AUTHOR); Currey, Heather N.¹ (AUTHOR); Hincks, Joshua C.¹ (AUTHOR)

• Source: PLoS Genetics. 12/26/2024, Vol. 20 Issue 12, p1-24. 24p.

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A behavioral screen for mediators of age-dependent TDP-43 neurodegeneration identifies SF2/SRSF1 among a group of potent suppressors in both neurons and glia.

• Authors : Azpurua, Jorge¹ (AUTHOR); El-Karim, Enas Gad¹ (AUTHOR); Tranquille, Marvel² (AUTHOR)

• Source: PLoS Genetics. 11/1/2021, Vol. 17 Issue 11, p1-19. 19p.

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Histone Deacetylases Suppress CGG Repeat–Induced Neurodegeneration Via Transcriptional Silencing in Models of Fragile X Tremor Ataxia Syndrome

• Authors : Todd, Peter K; Oh, Seok Yoon; Krans, Amy

Subjects: Adult; Male; 0301 basic medicine

• Source: PLoS GenetPLoS Genetics, Vol 6, Iss 12, p e1001240 (2010)

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The yeast stress inducible Ssa Hsp70 reduces α-synuclein toxicity by promoting its degradation through autophagy.

• Authors : Gupta, Arpit¹; Puri, Anuradhika¹; Singh, Prashant¹

• Source: PLoS Genetics. 10/30/2018, Vol. 14 Issue 10, p1-27. 27p.

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C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease.

• Authors : Kleinknecht, Alexandra^1,2; Popova, Blagovesta^1,2; Lázaro, Diana F.^2,3

• Source: PLoS Genetics. 6/24/2016, Vol. 12 Issue 6, p1-39. 39p.

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shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity.

• Authors : Gonçalves, Susana A.^1,2; Macedo, Diana^1,3; Raquel, Helena⁴

• Source: PLoS Genetics. 4/28/2016, Vol. 12 Issue 4, p1-26. 26p.

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DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization.

• Authors : Popova, Blagovesta¹ (AUTHOR); Wang, Dan¹ (AUTHOR); Pätz, Christina¹ (AUTHOR)

• Source: PLoS Genetics. 3/3/2021, Vol. 17 Issue 3, p1-37. 37p.

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