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Academic Journal

Synthesis of new shogaol analogues as NRF2 activators and evaluation of their anti-inflammatory activity, modes of action and metabolic stability

Subjects: 6-shogaol; Zingiber officinale; thiophene derivatives

  • Source: Mak, K-K, Shiming, Z, Sakirolla, R, Balijepalli, M K, Dinkova-Kostova, A T, Epemolu, O, Mohd, Z & Pichika, M R 2023, 'Synthesis of new shogaol analogues as NRF2 activators and evaluation of their

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Academic Journal

Chalcones identify cTXNPx as a potential antileishmanial drug target

Subjects: Animals; Antiprotozoal Agents/administration & dosage; Cells

  • Source: Escrivani, D O, Charlton, R L, Caruso, M B, Burle-Caldas, G A, Borsodi, M P G, Zingali, R B, Arruda-Costa, N, Palmeira-Mello, M V, de Jesus, J B, Souza, A M T, Abrahim-Vieira, B, Freitag-Pohl, S,

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Academic Journal

Mechanism of irreversible inhibition of Mycobacterium tuberculosis shikimate kinase by ilimaquinone

Subjects: Journal Article; Mycobacterium tuberculosis shikimate kinase; Shikimate‑3‑phosphate

  • Source: Simithy, J, Fuanta, N R, Hobrath, J V, Kochanowska-Karamyan, A, Hamann, M T, Goodwin, D C & Calderón, A I 2018, 'Mechanism of irreversible inhibition of Mycobacterium tuberculosis shikimate kinase by

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Academic Journal

Chitin-Binding Protein of Verticillium nonalfalfae Disguises Fungus from Plant Chitinases and Suppresses Chitin-Triggered Host Immunity

Subjects: Fungal effectors; Fungus–plant interactions; Mechanisms of pathogenicity

  • Source: Volk, H, Marton, K, Flajsman, M, Radisek, S, Tian, H, Hein, I, Podlipnik, Č, Thomma, B P H J, Kosmelj, K, Javornik, B & Berne, S 2019, 'Chitin-Binding Protein of Verticillium nonalfalfae Disguises

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Academic Journal

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3

Subjects: CPSF73; Drug discovery; Genetic screening

  • Source: Wall, R, Rico Vidal, E, Lukac, I, Zuccotto, F, Elg, S, Gilbert, I, Freund, Y R, Alley, M R K, Field, M, Wyllie, S & Horn, D 2018, 'Clinical and veterinary trypanocidal benzoxaboroles target CPSF3',

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Academic Journal

Slow-Binding Inhibition of Mycobacterium tuberculosis Shikimate Kinase by Manzamine Alkaloids

Subjects: Mycobacterium tuberculosis; shikimate kinase; manzamine alkaloids

  • Source: Simithy, J, Fuanta, N R, Alturki, M, Hobrath, J V, Wahba, A E, Pina, I, Rath, J, Hamann, M T, Deruiter, J, Goodwin, D C & Calderón, A I 2018, 'Slow-Binding Inhibition of Mycobacterium tuberculosis

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Academic Journal

Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit

Subjects: Binding Sites; Cross-Linking Reagents/chemistry; Molecular Docking Simulation

  • Source: Chojnacki, M, Mansour, W, Hameed, D S, Singh, R K, El Oualid, F, Rosenzweig, R, Nakasone, M A, Yu, Z, Glaser, F, Kay, L E, Fushman, D, Ovaa, H & Glickman, M H 2017, 'Polyubiquitin-Photoactivatable

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Academic Journal

Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway

Subjects: Binding Sites; Cell Line; HeLa Cells

  • Source: Nakasone, M A, Lewis, T A, Walker, O, Thakur, A, Mansour, W, Castañeda, C A, Goeckeler-Fried, J L, Parlati, F, Chou, T-F, Hayat, O, Zhang, D, Camara, C M, Bonn, S M, Nowicka, U K, Krueger, S,

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Academic Journal

Binding hotspots of BAZ2B bromodomain:histone interaction revealed by solution NMR driven docking

Subjects: Acetylation; Histones; Humans

  • Source: Ferguson, F M, Dias, D M, Rodrigues, J P G L M, Wienk, H, Boelens, R, Bonvin, A M J J, Abell, C & Ciulli, A 2014, 'Binding hotspots of BAZ2B bromodomain : histone interaction revealed by solution NMR

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