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The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

• Authors : Vivarelli, Marina; Barratt, Jonathan; Beck, Laurence H ...

Subjects: Humans; Biomarkers; Complement Activation

• Source: Kidney international, Vol. 106, no.3, p. 369-391 (2024)

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Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis.

• Authors : Akhlaghpour, Marzieh; Haritunians, Talin; More, Shyam K ...

Subjects: Humans; Complement Factor B; Crohn Disease

• Source: Gut, Vol. 72, no.11, p. 2068-2080 (2023)

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Functional and Genetic Landscape of Complement Dysregulation Along the Spectrum of Thrombotic Microangiopathy and its Potential Implications on Clinical Outcomes.

• Authors : Timmermans, Sjoerd A M E G; Damoiseaux, Jan G M C; Wérion, Alexis ...

Subjects: atypical hemolytic uremic syndrome; complement; eculizumab

• Source: Kidney international reports, Vol. 6, no.4, p. 1099-1109 (2021)

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Long-Term Efficacy and Safety of the Long-Acting Complement C5 Inhibitor Ravulizumab for the Treatment of Atypical Hemolytic Uremic Syndrome in Adults.

• Authors : Barbour, Thomas; Scully, Marie; Ariceta, Gema ...

Subjects: atypical hemolytic uremic syndrome; complement; hemolytic uremic syndrome

• Source: Kidney international reports, Vol. 6, no.6, p. 1603-1613 (2021)

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Diagnostic and Risk Factors for Complement Defects in Hypertensive Emergency and Thrombotic Microangiopathy.

• Authors : Timmermans, Sjoerd A M E G; Wérion, Alexis; Damoiseaux, Jan G M C ...

Subjects: Adult; Biopsy; Blood Pressure

• Source: Hypertension, Vol. 75, no. 2, p. 422-430 (2020)

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Complement system activation and peritoneal membrane alterations: Culprit or innocent bystander?

• Authors : Borceux, Pauline; Morelle, Johann; Goffin, Eric ...

Subjects: Nephrology; General Medicine; Angiogenesis

• Source: Peritoneal Dialysis International, Vol. 40, no. 2, p. 115-123 (2020)

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The long-acting C5 inhibitor, Ravulizumab, is effective and safe in adult patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment.

• Authors : Rondeau, Eric; Scully, Marie; Ariceta, Gema ...

Subjects: atypical hemolytic uremic syndrome; complement; eculizumab

• Source: Kidney international, Vol. 97, no. 6, p. 1287-1296 (2020)

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Complement Activation and Thrombotic Microangiopathies.

• Authors : Palomo, Marta; Blasco, Miquel; Molina, Patricia ...

Subjects: HELLP syndrome; alternative; antibodies

• Source: Clinical journal of the American Society of Nephrology : CJASN, Vol. 14, no. 12, p. 1719-1732 (2019)

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Epidemiology, Outcomes, and Complement Gene Variants in Secondary Thrombotic Microangiopathies.

• Authors : Wérion, Alexis; Storms, Pauline; Zizi, Ysaline ...

• Source: Clinical journal of the American Society of Nephrology, Vol. 18, no. 7, p. 881-891 (2023)

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High-force catch bonds between the Staphylococcus aureus surface protein SdrE and complement regulator factor H drive immune evasion

• Authors : Oliveira Paiva, Telmo Manuel; Geoghegan, Joan A.; Dufrêne, Yves ...

Subjects: General Agricultural and Biological Sciences; General Biochemistry; Genetics and Molecular Biology

• Source: Communications Biology, Vol. 6, no.1, p. 302 (2023)

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