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Small, Seeding-Competent Huntingtin Fibrils Are Prominent Aggregate Species in Brains of zQ175 Huntington's Disease Knock-in Mice

• Authors : Schindler, Franziska; Praedel, Nicole; Neuendorf, Nancy

Subjects: Huntington's disease; aggregates; seeding

• Source: Frontiers in Neuroscience, 15, Art. No. 682172, (2021-06-22)

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Why highly expressed proteins evolve slowly

• Authors : Drummond, D. Allan; Bloom, Jesse D.; Adami, Christoph

Subjects: evolutionary rate; protein misfolding; yeast

• Source: Proceedings of the National Academy of Sciences of the United States of America, 102(40), 14338-14343, (2005-10-04)

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Probing the Kinetic Stabilities of Friedreich's Ataxia Clinical Variants Using a Solid Phase GroEL Chaperonin Capture Platform

• Authors : Correia, Ana R.; Naik, Subhashchandra; Fisher, Mark T.

Subjects: clinical mutants; missense mutants; frataxin

• Source: Biomolecules, 4(4), 956-979, (2014-12)

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Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease

• Authors : Steele, Andrew D.; Hutter, Gregor; Jackson, Walter S.

Subjects: neurodegeneration; HSF1; transmissible spongiform encephalopathy

• Source: Proceedings of the National Academy of Sciences of the United States of America, 105(36), 13626-13631, (2008-09-09)

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System-wide analyses reveal essential roles of N-terminal protein modification in bacterial membrane integrity

• Authors : Yang, Chien-I; Zhu, Zikun; Jones, Jeffrey J.

Subjects: Molecular biology; Bacteriology; Omics

• Source: iScience, 25(8), Art. No. 104756, (2022-08-19)

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Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress

• Authors : Fang, Nancy N.; Chan, Gerard T.; Zhu, Mang

• Source: Nature Cell Biology, 16(12), 1227-1237, (2014-12)

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Exceptional rigidity and biomechanics of amyloid revealed by 4D electron microscopy

• Authors : Fitzpatrick, Anthony W. P.; Park, Sang Tae; Zewail, Ahmed H.

Subjects: cross-beta structure; nanomechanics; microcantilever

• Source: Proceedings of the National Academy of Sciences of the United States of America, 110(27), 10976-10981, (2013-07-02)

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The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration

• Authors : Chen, Danica; Steele, Andrew D.; Hutter, Gregor

Subjects: Sirtuin; Aging; Dietary restriction

• Source: Experimental Gerontology, 43(12), 1086-1093, (2008-12)

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