Recent Advances in the Production and Applications of Ellagic Acid and Its Derivatives. A Review.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, c1995-

Anti-Inflammatory Agents*/chemistry ; Anti-Inflammatory Agents*/therapeutic use ; Antioxidants*/chemistry ; Antioxidants*/therapeutic use ; Ellagic Acid*/analogs & derivatives ; Ellagic Acid*/chemistry ; Ellagic Acid*/therapeutic use; Hydrolyzable Tannins/*chemistry; Humans

Ellagitannins (ETs), characterized by their diversity and chemical complexity, belong to the class of hydrolysable tannins that, via hydrolysis under acidic or alkaline conditions, can yield ellagic acid (EA). They are mostly found as a part of extractives in angiosperms. As known antioxidants and chelators, EA and EA derivatives are drawing an increasing interest towards extensive technical and biomedical applications. The latter ones include possible antibacterial, antifungal, antiviral, anti-inflammatory, hepato- and cardioprotective, chemopreventive, neuroprotective, anti-diabetic, gastroprotective, antihyperlipidemic, and antidepressant-like activities, among others. EA's synthesis and production challenges prompt further research on new methods and alternative sources. Conventional and prospective methods and raw materials for the production of EA and its derivatives are reviewed. Among the potential sources of EA, the residues and industrial streams of the pulp industry have been highlighted and considered as an alluring alternative in terms of commercial exploitation.

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Keywords: antioxidant properties; bioavailability; biological activity; ellagic acid; ellagitannins; production routes; urolithins

0 (Anti-Inflammatory Agents)
0 (Antioxidants)
0 (Hydrolyzable Tannins)
19YRN3ZS9P (Ellagic Acid)

Date Created: 20200618 Date Completed: 20210211 Latest Revision: 20210211

20240105

PMC7355634

10.3390/molecules25122745

32545813