نبذة مختصرة : This thesis is focused on developing novel and fully automated methods for the detection of new multiple sclerosis (MS) lesions in longitudinal brain magnetic resonance imaging (MRI). First, we proposed a fully automated logistic regression-based framework for the detection and segmentation of new T2-w lesions. The framework was based on intensity subtraction and deformation field (DF). Second, we proposed a fully convolutional neural network (FCNN) approach to detect new T2-w lesions in longitudinal brain MR images. The model was trained end-to-end and simultaneously learned both the DFs and the new T2-w lesions. Finally, we proposed a deep learning-based approach for MS lesion synthesis to improve the lesion detection and segmentation performance in both cross-sectional and longitudinal analysis
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