Linking non-coding variants to function in microglia in Alzheimer’s disease

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المؤلفون: Yang, Xiaoyu; Wen, Jia; Yang, Han; Jones, Ian R; Zhu, Xiaodong; Liu, Weifang; Li, Bingkun; Clelland, Claire D; Luo, Wenjie; Wong, Man Ying; Ren, Xingjie; Cui, Xiekui; Song, Michael; Liu, Hongjiang; Chen, Cady; Eng, Nicolas; Ravichandran, Mirunalini; Sun, Yang; Lee, David; Van Buren, Eric; Jiang, Min-Zhi; Chan, Candace SY; Ye, Chun Jimmie; Perera, Rushika M; Gan, Li; Li, Yun; Shen, Yin
المصدر:
Nature Genetics. 55(10)
الوصف المادي :
1615 - 1616
الموضوع:
3101 Biochemistry and Cell Biology (for-2020); 3105 Genetics (for-2020); 31 Biological Sciences (for-2020); Genetics (rcdc); Brain Disorders (rcdc); Dementia (rcdc); Neurodegenerative (rcdc); Acquired Cognitive Impairment (rcdc); Human Genome (rcdc); Neurosciences (rcdc); Alzheimer's Disease (rcdc); Aging (rcdc); Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) (rcdc); 2.1 Biological and endogenous factors (hrcs-rac); Neurological (hrcs-hc); Humans (mesh); Alzheimer Disease (mesh); Microglia (mesh); Amyloid beta-Peptides (mesh); Genetic Predisposition to Disease (mesh); 31 Biological Sciences (for-2020); 3105 Genetics (for-2020); Genetics (rcdc); Dementia (rcdc); Neurosciences (rcdc); Neurodegenerative (rcdc); Biotechnology (rcdc); Brain Disorders (rcdc); Aging (rcdc); Acquired Cognitive Impairment (rcdc); Human Genome (rcdc); Alzheimer's Disease (rcdc); Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) (rcdc); 2.1 Biological and endogenous factors (hrcs-rac); Neurological (hrcs-hc); Humans (mesh); Alzheimer Disease (mesh); Microglia (mesh); Genome-Wide Association Study (mesh); Cell Membrane (mesh); Phenotype (mesh); Microglia (mesh); Cell Membrane (mesh); Humans (mesh); Alzheimer Disease (mesh); Phenotype (mesh); Genome-Wide Association Study (mesh); Humans (mesh); Alzheimer Disease (mesh); Microglia (mesh); Genome-Wide Association Study (mesh); Cell Membrane (mesh); Phenotype (mesh); 06 Biological Sciences (for); 11 Medical and Health Sciences (for); Developmental Biology (science-metrix); 3001 Agricultural biotechnology (for-2020); 3102 Bioinformatics and computational biology (for-2020); 3105 Genetics (for-2020)
نوع التسجيلة:
article
الدخول الالكتروني :
https://escholarship.org/uc/item/8xx0f532
https://escholarship.org/content/qt8xx0f532/qt8xx0f532.pdf

معلومة اضافية
- بيانات النشر:
  eScholarship, University of California, 2023.
- الموضوع:
  2023
- نبذة مختصرة :
  Genetic studies have associated thousands of non-coding variants with Alzheimer’s disease (AD), yet the functions of these variants remain elusive. We conducted cell-type-specific genetic fine mapping of AD variants and performed extensive functional characterization to unravel the causal variants that contribute to transcriptional regulation and ADrelated phenotypes in microglia.
- File Description:
  application/pdf
- الرقم المعرف:
  10.1038/s41588-023-01503-x
- Rights:
  public
- الرقم المعرف:
  edssch.oai:escholarship.org:ark:/13030/qt8xx0f532

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Linking non-coding variants to function in microglia in Alzheimer’s disease

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