Methods, apparatuses and systems for adolescent idiopathic scoliosis treatment

12150,977

16/877329

May 18, 2020

The METHODS, APPARATUSES AND SYSTEMS FOR ADOLESCENT IDIOPATHIC SCOLIOSIS TREATMENT (hereinafter “AIST”) disclosed herein leverage the biomechanical cause of AIS in the ventral portion of the interspinous ligament to treat AIS. In various embodiments, the AIST include chemically lysing the abnormal tethering structure, thereby allowing the AIS spine to decrease its deformity with usual day-to-day activities, without bracing and without instrumented and/or fusion surgery.

Kiester, Phillip Douglas (Irvine, CA, US)

Kiester, Phillip Douglas (Irvine, CA, US)

1. A method for treating adolescent idiopathic scoliosis, comprising: drilling a plurality of vertebral laminae of vertebrae in a patient spine to provide access holes to each of a corresponding plurality of interspinous ligaments, wherein the drilling is performed percutaneously, and wherein the drilling includes, for each of the plurality of vertebral laminae, creating an access hole that terminates at a ventral portion of the respective interspinous ligament at a location posterior of the corresponding ligamentum flavum, without drilling through the ligamentum flavum; cutting at least a ventral portion of each of the corresponding plurality of interspinous ligaments; and delivering collagenase clostridium histolyticum to the each of the corresponding plurality of interspinous ligaments via the access holes.

2. The method of claim 1 , wherein the plurality of vertebral laminae correspond to a thoracic portion of the patient spine.

3. The method of claim 1 , wherein the patient spine corresponds to a patient of age between 8 years and 19 years.

4. The method of claim 1 , wherein the drilling is performed using a drill with automatic stop.

5. A method for treating adolescent idiopathic scoliosis, comprising: exposing a patient spine for a patient of age between 8 years and 19 years who is diagnosed with adolescent idiopathic scoliosis; drilling a plurality of vertebral laminae of vertebrae in a thoracic portion of the patient spine to provide access holes to each of a corresponding plurality of interspinous ligaments, wherein the drilling is performed percutaneously, and wherein the drilling includes, for each of the plurality of vertebral laminae, creating an access hole that terminates at a ventral portion of the respective interspinous ligament at a location posterior of the corresponding ligamentum flavum, without drilling through the ligamentum flavum: cutting at least a ventral portion of each of the corresponding plurality of interspinous ligaments; and delivering collagenase clostridium histolyticum to the each of the corresponding plurality of interspinous ligaments via the access holes.

6. The method of claim 5 , wherein the plurality of vertebral laminae are drilled using a drill with automatic stop.

7. A method for treating adolescent idiopathic scoliosis, comprising: at each of a plurality of spinal segments, segmentally drilling lamina to create an access hole allowing access to a corresponding segmental tether disposed within the interspinous ligament at a location posterior of the corresponding ligamentum flavum, without drilling completely through the interspinous ligament and without drilling through the ligamentum flavum, wherein the segmentally drilling lamina is performed percutaneously; cutting the segmental tether at each of the interspinous ligaments; and injecting collagenase clostridium histolyticum through the access holes to contact each segmental tether.

8. The method of claim 7 , wherein the segmentally drilling lamina is performed using a drill having an automatic stop.

3678158 July 1972 Sussman
20030158545 August 2003 Hovda

Adams, Williams, “Lectures on the Pathology and Treatment of Lateral and Other Forms of Curvature of the Spine”, J & A Churchill, second edition 1882, originally published 1865, pp. 462-463, London. cited by applicant
Sommerville, E.W., “Rotational Lordosis: The Development of the Single Curve”, J Bone and Joint Surg, Aug. 1952; vol. 34B(3), pp. 421-427, Oxford, England. cited by applicant
Smith, R.M., et al., “Experimental Structural Scoliosis”, JBJS-B 1987; vol. 69-B(4), p. 576-581, Leeds. cited by applicant

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