Using supplemental information to improve inverse problem solutions

9,918,652

14/569145

December 12, 2014

A method may include storing electrical measurement data and geometry. One or more boundary conditions can be determined based on supplemental information associated with at least one selected location associated an anatomic envelope within a patient's body. Reconstructed electrical activity can be computed for a plurality of locations residing on the anatomic envelope within the patient's body based on the electrical data and the geometry data, the least one boundary condition being imposed to improve the computing.

CARDIOINSIGHT TECHNOLOGIES, INC. (Cleveland, OH, US)

Cadioinsight Technologies, Inc. (Cleveland, OH, US)

1. A method comprising: storing, in a memory device, electrical data representing electrical activity measured non-invasively at a plurality of surface measurement locations on a patient's body; storing, in the memory device, geometry data representing the surface measurement locations and geometry of patient anatomy including an anatomic envelope within the patient's body; determining, by a boundary condition generator, at least one boundary condition based on supplemental information associated with at least one selected location associated with the anatomic envelope within the patient's body, wherein determining the at least one boundary condition further comprises: determining a location on the anatomic envelope for each boundary condition; and determining a parameter value for each boundary condition; computing, by a reconstruction engine, reconstructed electrical activity for a plurality of locations residing on the anatomic envelope within the patient's body based on the electrical data and the geometry data, the least one boundary condition being imposed to improve the computing; and providing, by an output generator, an output based on the computed reconstructed electrical activity.

2. The method of claim 1 , wherein the supplemental information comprises at least one of intracardiac electrical measurements, imaging data, information associated with delivery of a cardiac therapy or user input data.

3. The method claim 1 , wherein at least one of the location on the anatomic envelope and the parameter value for each boundary condition is fixed with respect to time.

4. The method of claim 3 , wherein the at least one boundary condition comprises a region of a cardiac lesion associated with the anatomic envelope.

5. The method claim 1 , wherein at least one of the location on the anatomic envelope and the parameter value for each boundary condition is variable with respect to time.

6. The method of claim 5 , wherein the at least one boundary condition comprises a measurement of cardiac electrical activity associated with the location on the anatomic envelope.

7. The method of claim 1 , wherein computing reconstructed electrical activity further comprises extending a system of equations to incorporate equations that represent each boundary condition for a subset of the locations residing on the anatomic envelope within the patient's body.

8. The method of claim 1 , wherein the at least one boundary condition is determined based on the supplemental information acquired prior to measuring the electrical activity at the plurality of surface measurement locations on the patient's body.

9. The method of claim 1 , wherein the at least one boundary condition is determined based on the supplemental information acquired concurrently with measuring the electrical activity at the plurality of surface measurement locations on the patient's body.

10. The method of claim 1 , further comprising: placing a sensor at a known location in the patient's body to measure electrical activity at the known location; and using the measured electrical activity and the known location to define the at least one boundary condition.

11. The method of claim 1 , further comprising: placing a probe at a known location in the patient's body to supply at least one electrical signal having a predetermined electrical characteristic; using the predetermined electrical characteristic and the known location to define the at least one boundary condition.

12. The method of claim 1 , further comprising generating an electrocardiographic map based on the reconstructed electrical activity for the anatomic envelope within the patient's body.

13. A method comprising: storing, in a memory device, electrical data representing electrical activity measured non-invasively at a plurality of surface measurement locations on a patient's body; storing, in the memory device, geometry data representing the surface measurement locations and geometry of patient anatomy including an anatomic envelope within the patient's body; determining, by a boundary condition generator, at least one boundary condition based on supplemental information associated with at least one selected location associated with the anatomic envelope within the patient's body, wherein determining the at least one boundary condition further comprises: analyzing the supplemental information to ascertain a validity thereof for use as the at least one boundary condition; and selecting the at least one boundary condition based on the analyzing; and computing, by a reconstruction engine, reconstructed electrical activity for a plurality of locations residing on the anatomic envelope within the patient's body based on the electrical data and the geometry data, wherein computing reconstructed electrical activity uses each selected boundary condition, the least one boundary condition being imposed to improve the computing; and providing, by an output generator, an output based on the computed reconstructed electrical activity.

14. The method of claim 13 , wherein selecting the at least one boundary condition is in response to a user input.

15. The method of claim 13 , wherein analyzing the supplemental information further comprises analyzing image data to identify an anatomic region, the at least one boundary condition including locations on the anatomic envelope associated with the identified anatomic region.

16. A system comprising: a boundary condition generator programmed to determine one or more boundary conditions based on supplemental information wherein the boundary condition generator is configured to: determine a location on an anatomic envelope for each boundary condition based on the supplemental information; and determine a parameter value for each boundary condition based on the supplemental information; a reconstruction engine to compute an estimate of electrical activity distributed on the anatomic envelope within a patient's body based on electrical data representing electrical activity acquired non-invasively from locations on a patient's body and geometry data representing the locations on a patient's body and spatial geometry of patient including the anatomic envelope within the patient's body, the one or more boundary conditions being applied to constrain the computations to provide the estimate of electrical activity; and an output generator to provide output data based on the computed estimate of electrical activity.

17. The system of claim 16 , wherein the supplemental information comprises at least one of intracardiac electrical measurements, imaging data, information associated with delivery of a cardiac therapy or a user input data.

18. The system of claim 16 , wherein at least one of the location on the anatomic envelope and the parameter value for each boundary condition is fixed with respect to time.

19. The system of claim 16 , wherein at least one of the location on the anatomic envelope and the parameter value for each boundary condition is variable with respect to time.

20. A system comprising: a boundary condition generator programmed to determine one or more boundary conditions based on supplemental information, wherein the boundary condition generator further comprises: an analyzer to evaluate the supplemental information to ascertain a validity thereof for use as the one or more boundary conditions; and a selector to define each boundary condition, based on the analyzer, as to constrain the computations to provide the estimate of electrical activity; a reconstruction engine to compute an estimate of electrical activity distributed on an anatomic envelope within a patient's body based on electrical data representing electrical activity acquired non-invasively from locations on a patient's body and geometry data representing the locations on a patient's body and spatial geometry of patient including the anatomic envelope within the patient's body, the one or more boundary conditions being applied to constrain the computations to provide the estimate of electrical activity; and an output generator to provide output data based on the computed estimate of electrical activity.

21. A system comprising: a boundary condition generator programmed to determine one or more boundary conditions based on supplemental information; a user interface to selectively apply or not apply the one or more boundary conditions in response to a user input; a reconstruction engine to compute an estimate of electrical activity distributed on an anatomic envelope within a patient's body based on electrical data representing electrical activity acquired non-invasively from locations on a patient's body and geometry data representing the locations on a patient's body and spatial geometry of patient including the anatomic envelope within the patient's body, the one or more boundary conditions being applied to constrain the computations to provide the estimate of electrical activity; and an output generator to provide output data based on the computed estimate of electrical activity.

22. The system of claim 21 , further comprising: a sensor array including an arrangement of sensors positionable on a body surface of the patient; a non-invasive measurement system to process signals from each of the sensors in the sensor array and provide the electrical data representing electrical activity.

23. The system of claim 22 , further comprising: an implantable device that include at least one electrode; an invasive system communicatively coupled with the at least one electrode, the invasive system including circuitry to at least one of provide invasive electrical measurement data based on electrical activity sensed within the patient's body via the at least one electrode or supply an electrical signal for delivery at a target site within the patient's body via the at least one electrode.

24. The system of claim 23 , wherein the one or more boundary condition comprises a measurement of cardiac electrical activity determined from the invasive electrical measurement data.

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International Search Report; Applicant: CardioInsight Technologies, Inc.; International Application No. PCT/US2014/070079; International Filing Date: Dec. 12, 2014; Date of the Actual Completion of the International Search: Feb. 20, 2015; dated Mar. 12, 2015; Authorized Officer: Blaine R. Copenheaver; 2pgs. cited by applicant
PCT Written Opinion of the International Searching Authority; Applicant: CardioInsight Technologies, Inc.; International Application No. PCT/US2014/070079; International Filing Date: Dec. 12, 2014; Date of the Actual Completion of the International Search: Feb. 20, 2015; dated Mar. 12, 2015; Authorized Officer: Blaine R. Copenheaver; 5pgs. cited by applicant
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