COMPOSITION WITH VIRUCIDAL ACTIVITY, USE AND APPLICATION THEREOF

20250017879

18/705356

November 04, 2022

Increasingly, infectious diseases due to viruses, bacteria, fungi and other contact-transmissible microorganisms, droplets and/or aerosols, are acquiring greater importance due to globalisation and the ease of dissemination between very distant countries. A characteristic example is the Influenza A pandemic in 2009 and the SARS pandemics due to the SARS-Cov virus in 2003 and the COVID-19 pandemic due to the SARS-CoV-2 virus in 2020. To combat infections that may occur by contact, or by aerosolised drops (including those surfaces contaminated with infectious agents), a wider palette of antimicrobials and virucides is required. The present invention resolves this problem for viral infections with the use of a low toxicity surfactant from the group of trimethylammonium methyl sulfates.

1. Composition with virucidal activity characterised in that the active ingredient(s) is/are an aminium methyl sulfate selected from at least one of the following compounds: i) 3-(Undec-10-enamido)-N,N, N-trimethyl-propan-1-aminium methyl sulfate [chemical expression included] ii) 3-(Dodec-11-enamido)-N,N, N-trimethylpropan-1-aminium methyl sulfate [chemical expression included] iii) 3-(Undec-10-enamido)-N-ethyl-N,N-dimethylpropan-1-aminium methyl sulfate [chemical expression included] iv) 3-(Dodec-11-enamido)-N-ethyl-N,N-dimethylpropan-1-aminium methyl sulfate [chemical expression included]

2. Composition with virucidal activity according to claim 1, characterised in that the claimed compounds are in a concentration of 0.01% to 5% w/w in water.

3. Composition with virucidal activity according to claim 1, characterised in that the claimed compounds are in a concentration of 0.01% to 5% w/w in a 70% ethanol solution and the rest is propylene glycol.

4. Composition with virucidal activity according to claim 1, characterised in that it contains at least one of the claimed compounds and is active against lipid enveloped viruses and non-lipid enveloped viruses.

5. Composition with virucidal activity according to claim 4, characterised in that the concentration is from 0.1% to 0.3% w/w.

6. Composition with virucidal activity according to claim 1, characterised in that it is located inside a pressurised aerosol-generating container.

7. The use of the compounds according to claim 1, for the disinfection of viruses pathogenic to any animal or plant.

8. The use of the compounds according to claim 1, for the disinfection of viruses pathogenic to non-human mammalian animals.

9. The use of the compounds according to claim 1, for the disinfection of the following human viruses: Adeno-associated virus, Aichi virus, Australian bat lyssavirus, Astrovirus MLB1, Astrovirus VA1, BK polyomavirus, Banna virus, Barmah forest virus, Bundingo ebolavirus, Bunyamwera virus, Bunyavirus La Crosse, Bunyavirus snowshoe hare, Cercopithecine herpesvirus, Chandipura virus, Chikungunya virus, Cosavirus A, Cowpox virus, Coxsackievirus, Crimean-Congo hemorrhagic fever virus, Dengue virus, Dhori virus, Dugbe virus, Duvenhage virus, Eastern equine encephalitis virus, Ebolavirus, Echovirus, Encephalomyocarditis virus, Epstein-Barr virus, European bat lyssavirus, GB virus C, Hepatitis G virus, Hantaan virus, Hendra virus, Hepatitis A virus, Hepatitis B virus, Hepatitis C virus, Hepatitis E virus, Hepatitis delta virus, Horsepox virus, Human adenovirus, Human astrovirus, Human bocavirus, Human bocavirus 2, Human coronavirus (including SARS-CoV-1, SARS-CoV-2, MERS, HKU1, E229, OC43, NL63), Human cosaviruses A, B, C, D, E, Human cytomegalovirus, Human enterovirus 68, Human enterovirus 70, Human herpesvirus 1, Human herpesvirus 2, Human herpesvirus 6, Human herpesvirus 7, Human herpesvirus 8, Human immunodeficiency virus, Human papillomavirus 1, Human papillomavirus 2, Human papillomavirus 16, Human papillomavirus 18, Human papillomavirus 116, Human parainfluenza, Human parvovirus 4, Human parvovirus B19, Human respiratory syncytial virus, Human rhinovirus, Human SARS coronavirus, Human spumaretrovirus, Human T-lymphotropic virus, Human torovirus, Influenza A virus, Influenza B virus, Influenza C virus, Influenza A(H1N1)pdm09 virus, Influenza A(H3N2) viruses, Influenza A(H5N1) virus Isfahan virus, JC polyomavirus, Japanese encephalitis virus, Junin arenavirus, KI Polyomavirus, Klassevirus, Kunjin virus, Lagos bat virus, Lake Victoria Marburgvirus, Langat virus, Lassa virus, Lordsdale virus, Louping ill virus, Lymphocytic choriomeningitis virus, Machupo virus, Mayaro virus, Measles virus, Melaka virus, Mengo encephalomyocarditis virus, Merkel cell polyomavirus, Mokola virus, Molluscum contagiosum virus, Monkeypox virus, Mumps virus, Murray valley encephalitis virus, New York virus, Nipah virus, Norwalk virus, O'nyong-nyong virus, Orf virus, Oropouche virus, Pichinde virus, Poliovirus, Punta toro phlebovirus, Puumala virus, Rabies virus, Rift valley fever virus, Rosavirus A, Ross river virus, Rotavirus A, Rotavirus B, Rotavirus C, Rubella virus, Sagiyama virus, Salivirus A, Sandfly fever Sicilian virus, Sapporo virus, Semliki forest virus, Seoul virus, Simian foamy virus, Simian virus 5, Sindbis virus, Southampton virus, St. louis encephalitis virus, Tick-borne powassan virus, Torque teno virus, Toscana virus, Uukuniemi virus, Vaccinia virus, Varicella-zoster virus, Variola virus, Venezuelan equine encephalitis virus, Vesicular stomatitis virus, Western equine encephalitis virus, WU polyomavirus, West Nile virus, Yaba monkey tumor virus, Yaba-like disease virus, Yellow fever virus, Zika virus.

10. The use of the compounds according to claim 9, for the disinfection of viruses belonging to the coronavirus, influenza (flu), poliovirus, adenovirus and norovirus families.

11. A method of disinfecting viruses on surfaces comprising applying solutions containing the compounds claimed in claim 1 to the surfaces for at least five minutes.

12. Use of the virucidal compounds according to claim 1, in medicine and veterinary medicine as antivirals, both with topical route and other routes of medical and veterinary use.

61; 61

edspap.20250017879