COMBUSTION PRETREATMENT-ISOTOPE DILUTION MASS SPECTROMETRY

20150348768

14/655845

December 26, 2013

Provided is a combustion pretreatment-isotope dilution mass spectrometry measuring concentration of a target element for detection contained in a target sample for detection by using an isotope dilution mass spectrometry, including: pretreating the target sample for detection by combustion during an isotope dilution mass spectrometry, to thereby stabilize an isotope and further improve analysis ability, and therefore, the present invention is expected to be utilized as an element analysis method surpassing accuracy of the existing mass spectrometry method.

KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE (Daejeon, KR)

1. A combustion pretreatment-isotope dilution mass spectrometry measuring concentration of a target element for detection contained in a target sample for detection by using an isotope dilution inductively coupled plasma mass spectrometry, the combustion pretreatment-isotope dilution mass spectrometry, comprising: pretreating the target sample for detection by combustion during an isotope dilution mass spectrometry.

2. The combustion pretreatment-isotope dilution mass spectrometry of claim 1, comprising: performing an inductively coupled plasma-mass spectrometry on a first standard solution containing a reference isotope and an enriched isotope each at a predetermined amount, the reference isotope and the enriched isotope being isotopes of the target element for detection, to measure an isotope ratio between the reference isotope and the enriched isotope of the first standard solution; performing an inductively coupled plasma-mass spectrometry on a combusted material obtained by combusting the target sample for detection to measure an isotope ratio between a reference isotope and an enriched isotope contained in the target sample for detection; performing an inductively coupled plasma-mass spectrometry on a combusted material obtained by combusting a first mixed solution prepared by uniformly mixing the first standard solution with the target sample for detection to measure an isotope ratio between a reference isotope and an enriched isotope contained in the first mixed solution; and calculating concentration of the target element for detection contained in the target sample for detection by using the isotope ratios from a), b), and c).

3. The combustion pretreatment-isotope dilution mass spectrometry of claim 1, wherein the target element for detection is any one or two or more selected from the group consisting of Cl, Br, Cd, Pb, Hg, Se, Li, B, Mg, Si, S, K, Ca, Ti, V, Cr, Fe, Ni, Cu, Zn, Ga, Ge, Rb, Sr, Zr, Mo, Ru, Pd, Ag, In, Sn, Sb, Te, Cs, Ba, Ce, Nd, Sm, Eu, Gd, Dy, Er, Yb, Hf, Ta, W, Re, Os, Ir, Pt, Tl, and U.

4. The combustion pretreatment-isotope dilution mass spectrometry of claim 2, wherein the combustion of each of b) and c) is a pretreatment process of performing complete combustion at 900° C. to 1200° C. for 10 minutes to 60 minutes to obtain the combusted material.

5. The combustion pretreatment-isotope dilution mass spectrometry of claim 4, wherein the pretreatment process includes injecting an additive for complete combustion, collecting the combusted material in an absorbent solution, and adsorption-removing an organic material.

6. The combustion pretreatment-isotope dilution mass spectrometry of claim 5, wherein the additive for complete combustion is one or two or more selected from the group consisting of vanadium oxide, iron oxide, permanganate, chromate, osmium tetroxide, and perchlorate.

7. The combustion pretreatment-isotope dilution mass spectrometry of claim 5, wherein the absorbent solution is one or two or more selected from the group consisting of deionized water, sodium hydroxide, tetramethylammonium hydroxide, ammonium carbonate, and hydrogen peroxide.

8. The combustion pretreatment-isotope dilution mass spectrometry of claim 5, wherein the adsorption-removing of the organic material is a step of removing the organic material by using one or two or more adsorbents selected from the group consisting of deionized water, sodium hydroxide, tetramethylammonium hydroxide, ammonium carbonate, and hydrogen peroxide.

9. The combustion pretreatment-isotope dilution mass spectrometry of claim 1, comprising: performing an inductively coupled plasma-mass spectrometry on a second standard solution containing a reference isotope and an enriched isotope each at a predetermined amount, the reference isotope and the enriched isotope being isotopes of the target element for detection; and on a third standard solution containing a reference isotope and an enriched isotope each at a predetermined amount at a concentration which is different from that of the second standard solution, the reference isotope and the enriched isotope being isotopes of the target element for detection, to measure an isotope ratio between the reference isotope and the enriched isotope, of each of the second standard solution and the third standard solution; performing an inductively coupled plasma-mass spectrometry on a combusted material obtained by combusting the target sample for detection to measure an isotope ratio between a reference isotope and an enriched isotope contained in the target sample for detection; performing an inductively coupled plasma-mass spectrometry on a combusted material obtained by combusting a second mixed solution prepared by uniformly mixing the second standard solution with the target sample for detection, and on a combusted material obtained by combusting a third mixed solution prepared by uniformly mixing the third standard solution with the second standard solution, to measure an isotope ratio between a reference isotope and an enriched isotope contained in each of the second mixed solution and the third mixed solution; and calculating concentration of the target element for detection contained in the target sample for detection by using the isotope ratios from i), ii), and iii).

10. The combustion pretreatment-isotope dilution mass spectrometry of claim 9, wherein the combustion of each of ii) and iii) is a pretreatment process of performing complete combustion at 900° C. to 1200° C. for 10 minutes to 60 minutes to obtain the combusted material.

11. The combustion pretreatment-isotope dilution mass spectrometry of claim 10, wherein the pretreatment process includes injecting an additive for complete combustion, collecting the combusted material in an absorbent solution, and adsorption-removing an organic material.

12. The combustion pretreatment-isotope dilution mass spectrometry of claim 11, wherein the additive for complete combustion is one or two or more selected from the group consisting of vanadium oxide, iron oxide, permanganate, chromate, osmium tetroxide, and perchlorate.

13. The combustion pretreatment-isotope dilution mass spectrometry of claim 11, wherein the absorbent solution is one or two or more selected from the group consisting of deionized water, sodium hydroxide, tetramethylammonium hydroxide, ammonium carbonate, and hydrogen peroxide.

14. The combustion pretreatment-isotope dilution mass spectrometry of claim 11, wherein the adsorption-removing of the organic material is a step of removing the organic material by using one or two or more adsorbents selected from the group consisting of deionized water, sodium hydroxide, tetramethylammonium hydroxide, ammonium carbonate, and hydrogen peroxide.

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