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Friedewald and Martin–Hopkins formulae for estimating low-density lipoprotein cholesterol in a Malagasy population

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  • معلومة اضافية
    • Publisher Information:
      AOSIS 2026-02-09
    • نبذة مختصرة :
      Background: Low-density lipoprotein cholesterol (LDL-C) estimation is commonly used in Madagascar due to cost-effectiveness. However, genetic variability and formula limitations may affect accuracy.Objective: To compare LDL-C estimated by the Friedewald and Martin–Hopkins formulae with directly measured LDL-C in a Malagasy population.Methods: LDL-C values estimated using both formulae were compared with direct LDL-C in 346 samples from patients ≥ 18 years analysed in a biochemistry laboratory. Samples were divided into four groups based on triglyceride levels: 1.13 mmol/L; 1.13 mmol/L – 1.69 mmol/L; 1.69 mmol/L – 2.26 mmol/L; ≥ 2.26 mmol/L.Results: Both formulae showed a strong, statistically significant correlation with direct LDL-C (r = 0.89). Mean comparison revealed overestimation by both formulae, more pronounced with Friedewald (mean difference 0.15 mmol/L) than Martin–Hopkins (0.21 mmol/L). Differences increased with rising triglyceride levels. Both formulae demonstrated good agreement with direct measurement, acceptable biases and similar limits, but Friedewald had a lower overall percentage error.Conclusion: The Friedewald formula showed better correlation, higher concordance and lower mean difference than Martin–Hopkins. Both formulae showed limitations depending on triglyceride concentration.What this study adds: This study evaluates Friedewald and Martin–Hopkins LDL-C estimation against direct measurement in a Malagasy population, highlighting their validity in Africa and implications for clinical decisions in resource-limited settings.
    • الموضوع:
      Biology; low-density lipoprotein cholesterol; triglyceride; Friedewald formula; Martin–Hopkins formula; Madagascar; info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion
    • Availability:
      Open access content. Open access content
      Copyright (c) 2026 Faralahy H. Rakotonjafiniarivo, Tokinomenjanahary Antsonantenaina, Mahefa S. Rakotomalala, Rajo D. Andriambelo, Miora K. Ranaivosoa
      https://creativecommons.org/licenses/by/4.0
    • Note:
      text/html
      application/epub+zip
      text/xml
      application/pdf
      English
    • Other Numbers:
      ZAAOS oai:ohs.library.aosis.co.za:record/56027
      10.4102/ajlm.v15i1.3012
      1574797450
    • Contributing Source:
      AOSIS HOUSE
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1574797450
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