Fungsi Antioksidan dalam Menghambat Peroksidasi Lipid dan Meningkatkan Ketahanan Membran Eritrosit pada Penderita Diabetes Melitus

Antioxidant Function in Inhibiting Lipid Peroxidation and Increasing Erythrocyte Membrane Resistance in Diabetes Mellitus Patients

Poltekkes Kemenkes Kendari 2023-08-30

Diabetes melitus (DM) merupakan penyakit kronis yang berakar pada defisiensi insulin, menyebabkan gangguan metabolik dan komplikasi mikro- dan makrovaskular. Hiperglikemia pada DM memicu stres oksidatif dengan peningkatan produksi radikal bebas, merusak vaskular melalui aktivasi jalur diasilgliserol/protein kinase C dan peningkatan aktivitas polyol pathway. Dampak stres oksidatif termanifestasi dalam perubahan komposisi lipid pada membran eritrosit, meningkatkan resistensi aliran mikrovaskular, dan menghasilkan malondialdehyde (MDA) sebagai biomarker stres oksidatif. Sistem proteksi terhadap radikal bebas melibatkan enzim dan antioksidan non-enzimatik, yang bekerja bersama untuk menetralkan efek merusak radikal bebas. Pemahaman mendalam tentang interaksi ini membuka peluang untuk pengembangan strategi pencegahan dan penanganan komplikasi DM secara lebih efektif melalui penelitian lanjutan.
Diabetes mellitus (DM) is a chronic disease rooted in insulin deficiency, causing metabolic disorders and micro- and macrovascular complications. Hyperglycemia in DM triggers oxidative stress by increasing free radical production, damaging vascular through activation of the diacylglycerol/protein kinase C pathway and increased polyol pathway activity. The impact of oxidative stress manifests in changes in lipid composition on erythrocyte membranes, increases microvascular flow resistance, and produces malondialdehyde (MDA) as a biomarker of oxidative stress. The protection system against free radicals involves non-enzymatic enzymes and antioxidants, which work together to neutralize the damaging effects of free radicals. A deep understanding of these interactions opens up opportunities for the development of strategies for preventing and managing DM complications more effectively through continued research.

Diabetes melitus; Stres oksidatif; Radikal bebas; Antioksidan; Diabetes mellitus; Oxidative stress; Free radicals; Antioxidant; info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; Peer-reviewed Article; text; Artikel Reviu Komunitas; text

Open access content. Open access content
Copyright (c) 2023 Fonnie Esther Hasan, Reni Yunus (Author)
https://creativecommons.org/licenses/by-sa/4.0

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Indonesian

IDPKN oai:ojs2.myjurnal.poltekkes-kdi.ac.id:article/901
10.36990/hijp.v15i2.901
1422119273

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