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Hypertension with hidden causes:the cognitive and behavioral profile of an adult female with chronic stress and 16p11.2 microdeletion

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  • المؤلفون: Bos-Roubos, Anja G.; Wingbermühle, Ellen; Giesen, Mareike; Kersseboom, Rogier; De Graaff, Laura C.G.; Egger, Jos I.M.
  • المصدر:
    Bos-Roubos, A G, Wingbermühle, E, Giesen, M, Kersseboom, R, De Graaff, L C G & Egger, J I M 2024, 'Hypertension with hidden causes : the cognitive and behavioral profile of an adult female with chronic stress and 16p11.2 microdeletion', Journal of Hypertension, vol. 42, no. 1, pp. 179-184.
  • نوع التسجيلة:
    Electronic Resource
  • الدخول الالكتروني :
    https://pure.eur.nl/en/publications/27e250ae-5df3-487e-86b1-a0c78d29b9a7
  • معلومة اضافية
    • Publisher Information:
      2024-01-01
    • نبذة مختصرة :
      This case report aims to alert physicians to neuropsychological features and chromosomal variants that may underly resistant hypertension. We present a 35-year-old female patient with hypertensive crisis (BP 260/160 mmHg), initially treated with a combination of calcium antagonists, beta blockers, diuretics and angiotensin-converting enzyme (ACE)-inhibitors, though with little improvement. Cushing's syndrome, Conn's syndrome, and glucocorticoid receptor deficiency were ruled out. Multidisciplinary examination of medical history and (hetero)anamneses including psychosocial factors revealed mild dysmorphic body features, developmental delay, early diagnosis of autism spectrum disorder, a history of being bullied at school, little peer contact, learning disabilities, and special education. Neuropsychological assessment demonstrated below average to low average intelligence quotient, cognitive impairments, and psychopathology. Parallel genetic analyses revealed a rare 16p11.2 microdeletion syndrome. These concurrent examinations explained the patient's life-long high stress levels. After psychological treatment, with additional support at home, her blood pressure lowered to normal levels and antihypertensive drugs were no longer needed.
    • الموضوع:
      article
    • Availability:
      Open access content. Open access content
      info:eu-repo/semantics/openAccess
    • Note:
      application/pdf
      English
    • Other Numbers:
      QGQ oai:pure.eur.nl:publications/27e250ae-5df3-487e-86b1-a0c78d29b9a7
      https://pure.eur.nl/en/publications/27e250ae-5df3-487e-86b1-a0c78d29b9a7
      https://doi.org/10.1097/HJH.0000000000003565
      https://pure.eur.nl/ws/files/123986316/hypertension_with_hidden_causes_the_cognitive_and.21.pdf
      1417973034
    • Contributing Source:
      ERASMUS UNIVERSITEIT ROTTERDAM
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1417973034
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