نبذة مختصرة : Abstract Background Rapid advances in healthcare technologies and hospital informatization have prompted the need for enhanced nursing informatics literacy among undergraduate nursing students. Traditional nursing curricula often lack authentic, design-oriented learning experiences that integrate nursing, computer science, and information technology. Aim This four-year participatory action research study aimed to explore the effectiveness of a Design-Based Learning (DBL) approach in improving undergraduate nursing students’ informatics literacies within a “Nursing Informatics” course. Methods This study adopted a participatory action research design with a convergent mixed-methods approach. From 2020 to 2024, a total of 622 undergraduate nursing students at a comprehensive university in China were recruited through total population sampling from an iterative, DBL-enhanced “Nursing Informatics” course. Students tackled real-world clinical informatics problems through iterative cycles of investigation, design, and redesign. Pre- and post-course informatics literacy scores were measured using a validated 28-item, 5-point Likert scale questionnaire (total score range: 28–140). Paired t-tests and Bayesian modeling assessed improvements over time, while focus group interviews provided qualitative insights into students’ learning experiences. Results Across all four cohorts, informatics literacy scores improved significantly (p
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