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Endoplasmic reticulum stress of astrocytes in paraventricular nucleus of hypothalamus promotes ventricular electrical instability after acute myocardial infarction in rats

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  • معلومة اضافية
    • بيانات النشر:
      Frontiers Media S.A., 2025.
    • الموضوع:
      2025
    • Collection:
      LCC:Diseases of the circulatory (Cardiovascular) system
    • نبذة مختصرة :
      IntroductionAstrocytes in paraventricular nucleus of hypothalamus (PVN) promote the occurrence of ventricular arrhythmia (VA) after acute myocardial infarction (AMI). However, the mechanism is unclear. The purpose of this study was to investigate the changes of astrocytes in the PVN after AMI, which is involved in ventricular electrical instability in rats. MethodsThe rats were randomly divided into 4 groups: sham operation (SH), AMI, AMI + Vehicle (4 μl for each), AMI + GSK2606414(PERK phosphorylation inhibitor, 90 μg/4 μl for each). PVN was administered by microinjection.ResultsAfter 24 h, the AMI and AMI + Vehicle groups had substantially greater levels of hypothalamic astrocyte activation, endoplasmic reticulum (ER) stress, and central inflammation (TNF-α and IL-6) compared to the SH group (P
    • File Description:
      electronic resource
    • ISSN:
      2297-055X
    • Relation:
      https://www.frontiersin.org/articles/10.3389/fcvm.2025.1574146/full; https://doaj.org/toc/2297-055X
    • الرقم المعرف:
      10.3389/fcvm.2025.1574146
    • الرقم المعرف:
      edsdoj.7bd3b96ab3ec485d8220d25159c98ee1