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Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons

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  • معلومة اضافية
    • بيانات النشر:
      Nature Portfolio, 2021.
    • الموضوع:
      2021
    • Collection:
      LCC:Biology (General)
    • نبذة مختصرة :
      Using an unbiased genome-wide CRISPR screen approach, Sanchez et al. identified modulators of endogenous tau protein. This study suggests that chromatin modifiers, neddylation, ubiquitination, and the mTOR pathways regulate overall levels of tau protein in neurons, which could help in future identification of therapeutics for neurodegenerative diseases.
    • File Description:
      electronic resource
    • ISSN:
      2399-3642
    • Relation:
      https://doaj.org/toc/2399-3642
    • الرقم المعرف:
      10.1038/s42003-021-02272-1
    • الرقم المعرف:
      edsdoj.6974f96fa3e43eca73250a0892da4a2