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Identification of microRNAs and mRNAs associated with multidrug resistance of human laryngeal cancer Hep-2 cells

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  • معلومة اضافية
    • بيانات النشر:
      Associação Brasileira de Divulgação Científica, 2013.
    • الموضوع:
      2013
    • Collection:
      LCC:Medicine (General)
      LCC:Biology (General)
    • نبذة مختصرة :
      Multidrug resistance (MDR) poses a serious impediment to the success of chemotherapy for laryngeal cancer. To identify microRNAs and mRNAs associated with MDR of human laryngeal cancer Hep-2 cells, we developed a multidrug-resistant human laryngeal cancer subline, designated Hep-2/v, by exposing Hep-2 cells to stepwise increasing concentrations of vincristine (0.02-0.96'µM). Microarray assays were performed to compare the microRNA and mRNA expression profiles of Hep-2 and Hep-2/v cells. Compared to Hep-2 cells, Hep-2/v cells were more resistant to chemotherapy drugs (∼45-fold more resistant to vincristine, 5.1-fold more resistant to cisplatin, and 5.6-fold more resistant to 5-fluorouracil) and had a longer doubling time (42.33±1.76 vs 28.75±1.12'h, P
    • File Description:
      electronic resource
    • ISSN:
      1414-431X
    • Relation:
      http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000600546&lng=en&tlng=en; https://doaj.org/toc/1414-431X
    • الرقم المعرف:
      10.1590/1414-431X20131662
    • الرقم المعرف:
      edsdoj.65071e8eb43146fb9cce8304868d1ebe