نبذة مختصرة : Abstract Background Breast cancer is the leading cancer among women in Kuwait, yet mammography screening (MS) uptake remains suboptimal despite the Kuwait National Mammography Screening Program (KNMSP). This study identifies barriers to MS adherence among Kuwaiti women aged 40–69, focusing on sociocultural, knowledge-related, and systemic factors. Methods A cross-sectional study was conducted across five primary healthcare centers in Kuwait (June–August 2023) using semi-structured interviews with 201 women. Data were analyzed via SPSS to assess awareness, attitudes, and screening uptake. Results Only 25.4% of participants underwent MS within the past two years, with 52.2% never screened. Despite 91.5% being aware of screening programs, 84.6% exhibited poor overall awareness. Key barriers included fear of pain (77.6%) and physical discomfort (76.1%). Younger women (40–49 years) and employed individuals had significantly lower uptake (p = 0.001 and p = 0.004, respectively). Women invited to screen were 61.4% more likely to participate (p
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