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The use of folates for the prevention of fetal growth restriction during pregnancy ; Применение фолатов в профилактике задержки роста плода при беременности

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      REMEDIUM GROUP Ltd.
    • الموضوع:
      2018
    • Collection:
      Medical Council (E-Journal) / Медицинский Совет
    • نبذة مختصرة :
      Purpose of the study: Rational for the use of folates for the prevention of fetal growth restriction on the basis of the identification of a MTHFR polymorphism.Material and methods: 200 patients (case-control) were enrolled in the study. The (main) group I included 100 patients with fetal growth restriction (FGR), the (control) group II included 100 conditionally healthy patients. The features of the anamnesis, the initial clinical characteristics, the course of pregnancy, childbirth and the postpartum period in patients with placental insufficiency were studied in detail, and the features of the early neonatal period were analysed comprehensively. At the second stage, the polymorphism of the MMP2, MMP3, MMP9, and MTHFR genes was studied and their dependence with the development of the FGR was established. Statistical processing of the results was carried out on a personal computer using the SPSS Statistics 17.0 for Windows software package.Results: The clinical risk factors for the development of FGR include: chronic pyelonephritis, medium degree myopia, varicose veins, threat of abortion, ultrasound-detected subchorionic hemorrhage in the I trimester of gestation, anemia. Along with clinical risk factors for ZRP, the carriage of MTGFR (677 C> T) polymorphism is also considered, which justifies its identification in patients at risk.Conclusion: The data obtained make it possible to use the identification of MTHFR polymorphism as a predictor of placental abnormalities during pregnancy and to start taking folic acid supplements at the preconception stage in good time. Femibion 1 vitaminmineral complex has proved to be an effective product that is suitable for women in the period of preparation for pregnancy and in the first trimester of gestation, reducing the risk of fetal malformations and endothelial dysfunction caused by a violation of folic acid metabolism. ; Цель исследования: обоснование применения фолатов в профилактике задержки роста плода на основании определения полиморфизма генов MTHFR.Материал и ...
    • File Description:
      application/pdf
    • Relation:
      https://www.med-sovet.pro/jour/article/view/2606/2569; Доброхотова Ю.Э., Джобава Э.М., Степанян А.В. Рациональная витаминотерапия в группах риска по развитию акушерских осложнений. Гинекология, 2011, 1: 50–53.; Haider BA, Bhutta ZA. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst. Rev., 2012, 11: CD004905.; Showell MG, Brown J, Clarke J et al. Antioxidants for female subfertility. Cochrane Database Syst. Rev. 2013, 8: CD007807.; Сидельникова В.М. Подготовка и ведение беременности у женщин с привычным невынашиванием. М.: МЕД пресс-информ, 2013. 224 с.; Smith AD, Kim YI, Refsum H. Is folic acid good for everyone? Am J Clin Nutr, 2008, 87(3): 517-533.; Wang CH, Huang YF. Hyperhomocysteinemia and erectile dysfunction: an update. Zhonghua Nan Ke Xue, 2011, 17(11): 1019–1022.; Lombardo F, Tsamatropoulos P, Piroli E, Culasso F, Jannini EA, Dondero F, Lenzi A, Gandini L. Treatment of erectile dysfunction due to C677T mutation of the MTHFR gene with vitamin B6 and folic acid in patients non responders to PDE5i. J Sex Med, 2010, 7(1 Pt 1): 216-23 Epub 2009 Au.
    • الرقم المعرف:
      10.21518/2079-701X-2018-13-65-67
    • الدخول الالكتروني :
      https://www.med-sovet.pro/jour/article/view/2606
      https://doi.org/10.21518/2079-701X-2018-13-65-67
    • Rights:
      Authors publishing their articles in this journal shall agree to the following:Authors reserve the copyright to the work and grant the journal a license to publish the work for the first time Creative Commons Attribution License (CC BY- NC-ND), which allows other persons to distribute this work with the obligatory preservation of references to the authors of the original work and the original publication in this journal.Authors reserve the right to conclude separate contractual arrangements regarding the non-exclusive distribution of the work version in the form published here (for example, posting it in the institute’s repository, publication in a book), with reference to its original publication in this journal.Authors have the right to post work on the Internet (for example, in the institute’s repository or personal website) before and during the process of considering it by this journal, as this can result in a productive discussion and more references to this work. ; Авторы, публикующие в данном журнале, соглашаются со следующим:Авторы сохраняют за собой авторские права на работу и предоставляют журналу право первой публикации работы на условиях лицензии Creative Commons Attribution License (CC BY- NC-ND), которая позволяет другим распространять данную работу с обязательным сохранением ссылок на авторов оригинальной работы и оригинальную публикацию в журнале.Авторы сохраняют право заключать отдельные контрактные договорённости, касающиеся не-эксклюзивного распространения версии работы в опубликованном виде (например, размещение ее в институтском хранилище, публикацию в книге), со ссылкой на ее оригинальную публикацию.Авторы имеют право размещать работу в сети Интернет (например в институтском хранилище или персональном сайте) до и во время процесса рассмотрения ее данным журналом, так как это может привести к продуктивному обсуждению и большему количеству ссылок на данную работу. (См. The Effect of Open Access).
    • الرقم المعرف:
      edsbas.F655A5A3