Contributors: 清水, 秀憲; 宮本, 潤基; 久, 景子; 北野(大植), 隆司; 高田, 紘翠; 山野, 真由; 西田, 朱里; 笹原, 大暉; 増島, 侑紀; 渡辺, 啓太; 西川, 翔太; 高橋, 咲良; 池田, 貴子; 中島, 裕也; 吉田, 尚史; 松﨑, 千秋; 景山, 拓矢; 林, 息吹; 松木, 彩星; 明石, 涼; 北浜, 誠一; 上山, 雅子; 村上, 匠; 井貫, 晋輔; 入江, 潤一郎; 浅原, 哲子; 東樹, 宏和; 森, 宙史; 中岡, 慎治; 山下, 智也; 豊田, 敦; 山本, 憲二; 大野, 浩章; 片山, 高嶺; 伊藤, 裕; 木村, 郁夫; 51024674; 60948686; 60585024
نبذة مختصرة : 甘いもの好きの人の肥満を抑える腸内細菌の発見 --肥満や糖尿病などの代謝性疾患予防・治療法の開発応用に期待-- . 京都大学プレスリリース. 2025-02-03 ; Commensal bacteria affect host health by producing various metabolites from dietary carbohydrates via bacterial glycometabolism; however, the underlying mechanism of action remains unclear. Here, we identified Streptococcus salivarius as a unique anti-obesity commensal bacterium. We found that S. salivarius may prevent host obesity caused by excess sucrose intake via the exopolysaccharide (EPS) –short-chain fatty acid (SCFA) –carbohydrate metabolic axis in male mice. Healthy human donor-derived S. salivarius produced high EPS levels from sucrose but not from other sugars. S. salivarius abundance was significantly decreased in human donors with obesity compared with that in healthy donors, and the EPS–SCFA bacterial carbohydrate metabolic process was attenuated. Our findings reveal an important mechanism by which host–commensal interactions in glycometabolism affect energy regulation, suggesting an approach for preventing lifestyle-related diseases via prebiotics and probiotics by targeting bacteria and EPS metabolites.
Rights: © The Author(s) 2025 ; This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. ; http://creativecommons.org/licenses/by-nc-nd/4.0/
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