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Cytotoxic T lymphocyte–induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis

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  • معلومة اضافية
    • بيانات النشر:
      Rockefeller University Press
    • الموضوع:
      2006
    • نبذة مختصرة :
      Cytotoxic T lymphocyte (CTL)–induced death triggered by the granule exocytosis pathway involves the perforin-dependent delivery of granzymes to the target cell. Gene targeting has shown that perforin is essential for this process; however, CTL deficient in the key granzymes A and B maintain the ability to kill their targets by granule exocytosis. It is not clear how granzyme AB−/− CTLs kill their targets, although it has been proposed that this occurs through perforin-induced lysis. We found that purified granzyme B or CTLs from wild-type mice induced classic apoptotic cell death. Perforin-induced lysis was far more rapid and involved the formation of large plasma membrane protrusions. Cell death induced by granzyme AB−/− CTLs shared similar kinetics and morphological characteristics to apoptosis but followed a distinct series of molecular events. Therefore, CTLs from granzyme AB−/− mice induce target cell death by a unique mechanism that is distinct from both perforin lysis and apoptosis.
    • الرقم المعرف:
      10.1083/jcb.200510072
    • الدخول الالكتروني :
      https://doi.org/10.1083/jcb.200510072
      https://rupress.org/jcb/article-pdf/173/1/133/1874452/133.pdf
    • الرقم المعرف:
      edsbas.D2A2996D